Program Description
The primary focus of the laboratory program is the eosinophil, an enigmatic leukocyte whose role in innate immunity remains a subject of controversy. Among the mediators secreted by activated eosinophils are two ribonucleases known as eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN). Several studies have led Dr. Rosenberg's group to consider the role of eosinophils and the unique eosinophil ribonucleases and their interactions with respiratory virus pathogens.
Dr. Rosenberg's lab has developed a novel mouse model of respiratory viral infection using the natural rodent pneumovirus pathogen, pneumonia virus of mice (PVM). With this model, her laboratory is investigating the interactions of eosinophils with PVM and other clinically important respiratory pathogens and conducting several studies aimed at elucidating novel immunomodulatory therapies.
Biography
Dr. Rosenberg was awarded both M.D. and Ph.D. degrees from the joint program at The Rockefeller University and Cornell University Medical College (1984, 1985). Following postdoctoral research at Harvard University, she joined the National Institutes of Health in 1991 and became a section chief in 2002.
Editorial Boards
- Blood
- Journal of Leukocyte Biology
- Journal of Biological Chemistry
- Clinical and Experimental Allergy
- Journal of Immunology
Selected Publications
Rosenberg HF, Domachowske JB. Inflammatory responses to respiratory syncytial virus (RSV) infection and the development of immunomodulatory pharmacotherapeutics. Curr Med Chem.2012 Apr 1;19(10):1424-31.
Rigaux P, Killoran KE, Qiu Z, Rosenberg HF. Depletion of alveolar macrophages prolongs survival in response to acute pneumovirus infection. Virology. 2012 Jan 20;422(2):338–345.
Percopo CM, Dubovi EJ, Renshaw RW, Dyer KD, Domachowske JB, Rosenberg HF. Canine pneumovirus replicates in mouse lung tissue and elicits inflammatory pathology. Virology. 2011. Jul 20;416(1-2):26-31
Gabryszewski SJ, Bachar O, Dyer KD, Percopo CM, Killoran KE, Domachowske JB, Rosenberg HF. Lactobacillus-mediated priming of the respiratory mucosa protects against lethal pneumovirus infection. J Immunol. 2011 Jan 15;186(2):1151-61.
Dyer KD, Percopo CM, Fischer ER, Gabryszewski SJ, Rosenberg HF. Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6. Blood. 2009 Sep 24;114(13):2649-56.
Qiu Z, Dyer KD, Xie Z, Rådinger M, Rosenberg HF. GATA transcription factors regulate the expression of the human eosinophil-derived neurotoxin (RNase 2) gene. J Biol Chem. 2009 May 8;284(19):13099-109.
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