Alasdair M. Gilfillan, Ph.D.Building 10, Rm 11C20610 Center DriveBethesda MD 20892-1881Phone: 301-496-8757Fax: email@example.com
Special Volunteer, Mast Cell Biology Section, LAD
Dr. Gilfillan received his Ph.D. from the University of Manchester, United Kingdom, and then did his postdoctoral training at Yale University Medical School. Following a number of years spent conducting pre-clinical research at Hoffmann La-Roche in the areas of allergy and inflammation, he joined the Mast Cell Biology Section of the Laboratory of Allergic Diseases in 1999. Dr. Gilfillan has a long-standing interest in signaling pathways associated with receptor-mediated activation of mast cells.
Kuehn HS, Jung MY, Beaven MA, Metcalfe DD, Gilfillan AM. Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. J Biol Chem. 2011 Jan 7;286(1):381-402.
Gilfillan AM, Metcalfe DD, editors. Mast cell biology: contemporary and emerging topics. Austin, TX: Landes Bioscience; 2011.
Smrž D, Iwaki S, McVicar DW, Metcalfe DD, Gilfillan AM. TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release. Eur J Immunol. 2010 Dec;40:3557-61.
Kuehn HS, Rådinger M, Brown JM, Ali K, Vanhaesebroeck B, Beaven MA, Metcalfe DD, Gilfillan AM. Btk-dependent Rac activation and actin rearrangement following FceRI aggregation promotes enhanced chemotactic responses. J Cell Sci. 2010 Aug 1;123(Pt 15):2576-85.
Kataoka TR, Kumanogoh A, Bandara G, Metcalfe DD, Gilfillan AM. CD72 negatively regulates KIT-mediated responses in human mast cells. J Immunol. 2010 Mar 1;184(5):2468-75
Rådinger M, Kuehn HS, Kim MS, Metcalfe DD, Gilfillan AM. Glycogen synthase 3β activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells. J Immunol. 2010 Jan 15;184(2):564-72.
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Last Updated February 13, 2013
Last Reviewed February 13, 2013