Biography
Dr. Gilfillan received his Ph.D. from the University of Manchester, United Kingdom, and then did his postdoctoral training at Yale University Medical School. Following a number of years spent conducting pre-clinical research at Hoffmann La-Roche in the areas of allergy and inflammation, he joined the Mast Cell Biology Section of the Laboratory of Allergic Diseases in 1999. Dr. Gilfillan has a long-standing interest in signaling pathways associated with receptor-mediated activation of mast cells.
Memberships
- American Association of Immunologists
- American Society for Biochemistry and Molecular Biology
Editorial Boards
- World Journal of Biological Chemistry (2010- )
- Journal of Immunology (2008- )
- Immunology Letters (2007- )
- The Open Immunology Journal (2007- )
- The Open Allergy Journal (2007- )
- Journal of Pharmacology and Experimental Therapeutics (1994-2001)
Selected Publications
Kuehn HS, Jung MY, Beaven MA, Metcalfe DD, Gilfillan AM. Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release. J Biol Chem. 2011 Jan 7;286(1):381-402.
Gilfillan AM, Metcalfe DD, editors. Mast cell biology: contemporary and emerging topics. Austin, TX: Landes Bioscience; 2011.
Smrž D, Iwaki S, McVicar DW, Metcalfe DD, Gilfillan AM. TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release. Eur J Immunol. 2010 Dec;40:3557-61.
Kuehn HS, Rådinger M, Brown JM, Ali K, Vanhaesebroeck B, Beaven MA, Metcalfe DD, Gilfillan AM. Btk-dependent Rac activation and actin rearrangement following FceRI aggregation promotes enhanced chemotactic responses. J Cell Sci. 2010 Aug 1;123(Pt 15):2576-85.
Kataoka TR, Kumanogoh A, Bandara G, Metcalfe DD, Gilfillan AM. CD72 negatively regulates KIT-mediated responses in human mast cells. J Immunol. 2010 Mar 1;184(5):2468-75
Rådinger M, Kuehn HS, Kim MS, Metcalfe DD, Gilfillan AM. Glycogen synthase 3β activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells. J Immunol. 2010 Jan 15;184(2):564-72.
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