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Laboratory of Allergic Diseases

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Arnold S. Kirshenbaum, M.D.

Photo of Arnold S. Kirshenbaum, M.D.

Special Volunteer, Mast Cell Biology Section, LAD

Major Areas of Research

  • Mast cell growth and differentiation from progenitor cells
  • Regulation of normal and neoplastic mast cell growth
  • Systemic mast cell disorders
  • Role of mast cells in disorders with single gene defects


Dr. Kirshenbaum received his M.D. at Georgetown University in Washington, DC. He did an internship and residency in pediatrics at the Naval Regional Medical Center affiliated with the University of California, San Francisco. Dr. Kirshenbaum trained in allergy and immunology during a fellowship at NIAID and is currently an adjunct investigator in the Laboratory of Allergic Diseases, NIAID. Dr. Kirshenbaum also practices adult and pediatric allergy and immunology in offices in Bowie, Maryland.


  • American Academy of Allergy, Asthma & Immunology (Fellow)
  • American Academy of Pediatrics, Maryland Chapter

Selected Publications

Chan EC, Bai Y, Kirshenbaum AS, Fischer ER, Simakova O, Bandara G, Scott LM, Wisch LB, Cantave D, Carter MC, Lewis JC, Noel P, Maric I, Gilfillan AM, Metcalfe DD, Wilson TM. Mastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype. J Allergy Clin Immunol. 2014 Feb 27. Epub ahead of print

North SJ, von Gunten S, Antonopoulos A, Trollope A, MacGlashan DW Jr, Jang-Lee J, Dell A, Metcalfe DD, Kirshenbaum AS, Bochner BS, Haslam SM. Glycomic analysis of human mast cells, eosinophils and basophils. Glycobiology. 2012 Jan;22(1):12-22.

Rådinger M, Jensen BM, Kuehn HS, Kirshenbaum A, Gilfillan AM. Generation, isolation, and maintenance of human mast cells and mast cell lines derived from peripheral blood or cord blood. Curr Protoc Immunol. 2010 Aug; Chapter 7: Unit 7. 37.

Sundstrom JB, Hair GA, Ansari AA, Secor WE, Gilfillan AM, Metcalfe DD, Kirshenbaum AS. IgE-FcepsiolonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells. J Immunol. 2009 May 15;182(10):6401–9.

Kirshenbaum AS, Swindle E, Kulka M, Wu Y, Metcalfe DD. Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition. BMC Immunol. 2008 Aug 7;9:45.

Maric I, Robyn J, Metcalfe DD, Fay MP, Carter M, Wilson T, Fu W, Stoddard J, Scott L, Hartsell M, Kirshenbaum A, Akin C, Nutman TB, Noel P, Klion AD. KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. J Allergy Clin Immunol. 2007 Sep;120(3):680-7.

Visit PubMed for a complete publication listing.

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Last Updated May 30, 2014