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Laboratory of Allergic Diseases

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Zhihui (Sherry) Xie, Ph.D.

Staff Scientist, Molecular Signal Transduction Section, LAD

Major Areas of Research

  • Regulation of signaling pathways induced by GPCRs
  • The role of mast cells and basophils in allergic inflammation
  • Pathogenesis of vascular hyper-permeability in SCLS
 

Program Description

The primary research focus of our laboratory is to understand the signaling pathways induced by G-protein coupled receptors (GPCRs), particularly the role of regulator of G-protein signal (RGS) proteins in leukocyte trafficking and the pathogenesis of asthma and allergic diseases. Our lab discovered that RGS13 negatively regulates FcεRI-mediated mast cell degranulation. Mice deficient in RGS13 displayed enhanced antigen-stimulated anaphylaxis, suggesting a potential novel therapeutic target. We also found that RGS13 protein degradation is protected by PKA phosphorylation on Thr41 residue, while RGS13 mRNA transcription was negatively regulated by the tumor suppressor p53. More recently, our lab has begun to explore the pathogenesis of a rare disease, the systemic capillary leak syndrome (SCLS). Permeability of human microvascular endothelial cells in vitro by disrupting adherens junctions through internalization of the surface junctional molecule VE-cadherin.

Biography

Dr. Xie received her Ph.D. in basic medical science from The Chinese University of Hong Kong, School of Medicine. She obtained postdoctoral training in the areas of IgE receptor FcεRI-mediated mast cell signal transduction and functions at the National Institute of Dental and Craniofacial Research from 1997 to 2001. Prior to joining the Laboratory of Allergic Diseases in 2004, Dr. Xie conducted cancer research at the Lombardi Cancer Center, Georgetown University.

Memberships

  • American Society for Biochemistry and Molecular Biology
  • North American Vascular Biology Organization

Selected Publications

Xie Z, Ghosh CC, Patel R, Iwaki S, Gaskins D, Nelson C, Jones N, Greipp PR, Parikh SM, Druey KM. Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood. 2012 Mar 15. Epub ahead of print.

Iwaki S, Lu Y, Xie Z, Druey KM. p53 negatively regulated RGS13 protein expression in immune cells. J Biol Chem. 2011 Jun 24;286(25):22219-26.

Xie Z, Yang Z, Druey KM. Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradationJ Mol Cell Biol. 2010 Dec; 2(6):357-65.

Xie Z, Geiger TR, Johnson EN, Nyborg JK, Druey KM. RGS13 acts as a nuclear repressor of CREB. Mol Cell. 2008 Sep 5;31(5):660-70.

Bansal G, Xie Z, Rao S, Nocka KH, Druey KM. Suppression of IgE-mediated allergic responses by regulator of G protein signaling 13Nat Immunol. 2008 Jan;9(1):73-80.

Bansal G, Druey KM, Xie Z. R4 RGS proteins: regulation of G-protein signaling and beyondPharmacol Ther. 2007 Dec;116(3):473-95.

Visit PubMed for a complete publication listing.

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Last Updated March 27, 2012

Last Reviewed June 24, 2011