Laboratory of Clinical Infectious Diseases

Steven M. Holland, M.D., Chief

The Laboratory of Clinical Infectious Diseases (LCID) conducts clinical and basic studies of important human infectious and immunologic diseases. Sections of the laboratory focus on mycobacterial, bacterial, viral, and fungal infections, as well as the acquired and congenital immune disorders associated with infection susceptibility and resistance. The program integrates clinical, cellular, and molecular investigation, including animal models and human natural history and therapeutic trials.

The defining feature of LCID is the focus on patients and their infections in order to develop a comprehensive understanding of natural history, pathogenesis, pathophysiology, and management of diseases.

Training of physicians and scientists is central to the LCID mission. The NIAID infectious diseases training program and the National Institutes of Health Clinical Center infectious disease consultation service are located in LCID and are involved in all aspects of both clinical and laboratory activities. The integration of these programs into LCID is critical to the reciprocal education of basic scientists and clinical fellows alike.

The major themes of the laboratory center on infections that are recurrent or chronic, as these provide insight into both host and pathogen.

Selected Major Areas of Research

• Immune defects of phagocytes
• Cytokines in the pathogenesis and therapy of infections
• Mechanisms of bacterial pathogenesis
• Tuberculosis drug discovery, mechanisms of action, and resistance
• Mechanism of action of existing and new antituberculosis agents
• Mechanisms of fungal pathogenesis (Cryptococcus and Aspergillus)
• Pathogenesis, treatment, and vaccines for human herpesviruses
• Pathogenesis and treatment of autoimmune lymphoproliferative syndrome (ALPS)
• Diagnosis and treatment of Lyme disease

Selected Clinical Protocols in the LCID

• Natural history and therapies of bacterial, mycobacterial, fungal, or viral infections
• Natural history and therapies of immune defects
• Immune responses to infections and vaccines
• Identification of novel bacteria, mycobacteria, viruses, fungi
• Lyme disease
• Autoimmune lymphoproliferative syndrome (ALPS)

Office of the Chief

Steven M. Holland, M.D.
Tara N. Palmore, M.D.

Antibacterial Host Defense Section

Robert S. Munford, M.D.

Autoimmune Lymphoproliferative Syndrome Unit

V. Koneti Rao, M.D.

Bacterial Pathogenesis Section

Sandip Datta, M.D.

Clinical Mycology Section

John E. Bennett, M.D.

Clinical Studies Unit

Adriana R. Marques, M.D.

Epidemiology Section

D. Rebecca Prevots, Ph.D., M.P.H.
Ruben Montes de Oca, M.S.
Amy E. Seitz, M.P.H.

Immunopathogenesis Section

Steven M. Holland, M.D.
Alexandra F. Freeman, M.D.
Kenneth N. Olivier, M.D.
Elizabeth Sampaio, M.D., Ph.D.
Gulbu Uzel, M.D.
Adrian Zelazny, M.D.

Infectious Disease Consultation Service

Juan Gea-Banacloche, M.D.

Infectious Disease Fellowship Training Program

Tara N. Palmore, M.D.
John E. Bennett, M.D.

Molecular Microbiology Section

Kyung (June) Kwon-Chung, Ph.D.
Yun Chang, Ph.D.

Translational Mycology Unit

Peter Williamson M.D., Ph.D.

Tuberculosis Research Section

Clifton E. Barry, III, Ph.D.
Matthew Carroll, M.D.
Laura Via, Ph.D.

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