V. Koneti Rao, M.D. Building 10, Room 12C106 10 Center DriveBethesda, MD 20892-1892Phone: 301-496-6502 Fax: firstname.lastname@example.org
Autoimmune Lymphoproliferative Syndrome (ALPS)
Autoimmune Lymphoproliferative Syndrome (ALPS) is an inherited disorder of the immune system that affects both children and adults. In ALPS, unusually high numbers of white blood cells, called lymphocytes, accumulate in the lymph nodes, liver, and spleen, which can lead to enlargement of these organs. ALPS can also cause a variety of autoimmune problems such as anemia (low red blood cell count), thrombocytopenia (low platelets), and neutropenia (low neutrophil count).
The ALPS Unit aims to better understand this rare disease, to find the cause, and to uncover new ways to treat it. Its ultimate goal is to find a cure.
Susan M. Price, R.N.; Kennichi Dowdell, Ph.D.; Katie Perkins, C.R.N.P.
To view a complete listing, visit PubMed.
Rao VK, Oliveira JB. How I treat autoimmune lymphoproliferative syndrome. Blood. 2011 Nov 24;118(22):5741-51.
Oliveira JB, Bleesing JJ, Dianzani U, Fleisher TA, Jaffe ES, Lenardo MJ, Rieux-Laucat F, Siegel RM, Su HC, Teachey DT, Rao VK. Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome (ALPS): report from the 2009 NIH International Workshop. Blood. 2010 Oct 7;116(14):e35-40.
Oliveira JB, Bleesing JJ, Dianzani U, Fleisher TA, Jaffe ES, Lenardo MJ, Rieux-Laucat F, Siegel RM, Su HC, Teachey DT, Rao VK. Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome: report from the 2009 NIH International Workshop. Blood. 2010 Jun 10.
Dowdell KC, Niemela JE, Price S, Davis J, Hornung RL, Oliveira JB, Puck JM, Jaffe ES, Pittaluga S, Cohen JI, Fleisher TA, Rao VK. Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome. Blood. 2010 Jun 24;115(25):5164-9.
Turbyville JC, Rao VK. The autoimmune lymphoproliferative syndrome: A rare disorder providing clues about normal tolerance. Autoimmun Rev. 2010 May;9(7):488-93.
Caminha I, Fleisher TA, Hornung RL, Dale JK, Niemela JE, Price S, Davis J, Perkins K, Dowdell KC, Brown MR, Rao VK, Oliveira JB. Using biomarkers to predict the presence of FAS mutations in patients with features of the autoimmune lymphoproliferative syndrome. J Allergy Clin Immunol. 2010 Apr;125(4):946-949.e6.
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Last Updated January 18, 2011