The Bacterial Pathogenesis Unit has the goal of understanding how host-bacteria interactions shape subsequent immune responses and using this knowledge to modulate and optimize host defense. We are using cellular, animal model, and patient-based studies to investigate the following areas:
Sandip Datta received his M.D. from University of California, San Francisco, in 1996. He then completed his residency in internal medicine and fellowship in infectious diseases at University of California, San Diego (UCSD), including postdoctoral training with Dr. Eyal Raz. Dr. Datta was appointed as assistant professor of medicine at UCSD in 2004. In February 2008, he joined the LCID as tenure-track chief of the newly formed Bacterial Pathogenesis Unit.
Inka Sastalla, Ph.D., Staff ScientistIan Myles, M.D., Assistant Clinical InvestigatorBrian Janelsins, Ph.D., Research ScientistHatice Karauzum, Ph.D., Research FellowKelli Williams, M.D., Clinical FellowPortia Gough, B.S., Graduate StudentChristian Haudenschild, B.S., Post-baccalaureate IRTAJensen Reckhow, B.S., Postdoctoral IRTA
Janelsins BM, Lu M, Datta SK. Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):373-8.
Myles IA, Fontecilla NM, Valdez PA, Vithayathil PJ, Naik S, Belkaid Y, Ouyang W, Datta SK. Signaling via the IL-20 receptor inhibits cutaneous production of IL-1<beta> and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus. Nat Immunol. 2013;14(8):804-11.
Myles IA, Fontecilla NM, Janelsins BM, Vithayathil PJ, Segre JA, Datta SK. Parental dietary fat intake alters offspring microbiome and immunity. J Immunol. 2013 Aug 9. 2013 Sep 15;191(6):3200-9.
Gaidamakova EK#, Myles IA#, McDaniel DP, Fowler CJ, Valdez PA, Gayen M, Gupta P, Sharma A, Glass PJ, Maheshwari RK, Datta SK*, Daly MJ*. Preserving immunogenicity of lethally irradiated viral and bacterial vaccine epitopes using a radio- protective Mn2+-Peptide complex from Deinococcus. Cell Host Microbe. 2012 Jul 19;12(1):117-24. (*equal co-corresponding authors, #equal contributors)
Valdez PA, Vithayathil PJ, Janelsins BM, Shaffer AL, Williamson PR, Datta SK. Prostaglandin e2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells. Immunity. 2012 Apr 20;36(4):668-79.
Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10638-43.
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Last Updated November 14, 2014