Sharon H. Jackson, M. D.Building 10-CRC, Room 5-394210 Center DriveBethesda, MD 20852-8190Phone: 301-435-8540Fax: email@example.com
Sharon H. Jackson, M.D., received her medical degree from the State University of New York at Buffalo Medical School and completed her pediatrics training at Mount Sinai Hospital, New York. She completed postdoctoral training and subspecialty training in allergy and immunology at NIAID. Dr. Jackson joined the tenure-track in 2001.
Investigations conducted in the Monocyte Trafficking Unit (MTU) are focused on understanding how p47phox, a cytosolic subunit of the phagocyte NADPH oxidase, regulates adaptive and innate immune-cell function. The phagocyte NADPH oxidase has been recognized as the primary innate antimicrobial host defense system used for protection against pathogenic microorganisms. The enzymatic complex consists of the membrane-associated gp91phox and p22phox subunits (cytochromeb558) and the cytosolic subunits p47phox, p67phox, p40phox, and regulatory GTPase Rac2.
Ongoing investigations in MTU revealed that in the absence of NADPH oxidase p47phox, several critical immune cell functions are dysregulated. Specifically, our recent work has shown that NADPH oxidase p47phox-/- antigen-presenting cells (dendritic cells and macrophages) and T cells exhibit aberrant cytokine responses, and that NADPH oxidase p47phox-/- T cells also exhibit an intrinsic survival defect. These observations extend the function of p47phox beyond its recognized role in innate immunity as a regulatory protein in phagocytic cell ROS production, to include the regulation of non-phagocytic cellular networks that affect cell proliferation, cell death, and cytokine secretion.
The interrelated objectives of our research program are to characterize NADPH oxidase p47phox regulation of the following:
Important objectives of our program are research and training. If you wish to inquire about postdoctoral training or other positions in the MTU, contact Dr. Jackson directly.
For a complete listing, visit PubMed.
Donaldson M, Antignani A, Milner J, Zhu N, Wood A, Cardwell-Miller L, Changpriroa CM, Jackson SH. p47(phox)-deficient immune microenvironment signals dysregulate naive T-cell apoptosis. Cell Death Differ. 2009 Jan;16(1):125-38.
Liu Q, Cheng LI, Yi L, Wood A, Changpriroa C, Ward JM, Jackson SH. p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia. Am J Pathol. 2009 Jan;174(1):153-63.
Ge Y, Montano I, Rustici G, Freebern WJ, Haggerty CM, Cui W, Ponciano-Jackson D, Chandramouli GV, Gardner ER, Figg WD, Abu-Asab M, Tsokos M, Jackson SH, Gardner K. Selective leukemic-cell killing by a novel functional class of thalidomide analogs. Blood. 2006 Dec 15;108(13):4126-35.
Jackson SH, Yu CR, Mahdi RM, Ebong S, Egwuagu CE. Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signaling. J Immunol. 2004 Feb 15;172(4):2307-15.
Jackson SH, Devadas S, Kwon J, Pinto LA, Williams MS. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol. 2004 Aug;5(8):818-27.
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Last Updated January 28, 2011