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Laboratory of Immunology

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William E. Paul, M.D., Chief

301-496-5046

wpaul@niaid.nih.gov

The major research activities of Laboratory of Immunology scientists concern the basic genetics, molecular biology, cell biology, and cellular immunology of the immune system. How dysregulation of the immune system results in autoimmune diseases and what strategies might be valuable for vaccine development are important topics of interest.

Sections and Units

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Major Areas of Research

  • Structure of pattern recognition receptors
  • miRNA regulation of immune cell function
  • T-cell development, differentiation, and plasticity
  • Transcriptional regulation of lymphocyte differentiation
  • Regulation of primary and secondary immune responses
  • Cytokine biology, transcriptional networks, and signaling mechanisms
  • Programmed cell death and autophagy
  • Biology of regulatory T cells and control of autoimmunity
  • Role of T regulatory cells in chronic infection
  • Induction of T-cell tolerance and treatment of autoimmunity
  • Lymphocyte dynamics
  • Structure and function of viral immunoevasins
  • Analysis of genetically determined defects in human T-cell death

Last Updated January 10, 2014