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Joseph Brzostowski, Ph.D.
Twinbrook II, Room 201
12441 Parklawn Drive
Bethesda, MD 20892-8180
Phone: 301-443-2967
Fax: 301-402-0259
brzostowskij@niaid.nih.gov

Related Link

LIG Imaging Facility

Laboratory of Immunogenetics

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Joseph Brzostowski, Ph.D.

Photo of Joseph Brzostowski, Ph.D.

Chief, LIG Imaging Facility, LIG
Staff Scientist, Lymphocyte Activation Section, LIG

 

Biography

Dr. Brzostowski received his B.A. from Rutgers College in 1990 and his Ph.D. in 1998 from the University of Virginia. As a postdoctoral fellow at the National Institute of Diabetes, Digestive and Kidney Diseases, Dr. Brzostowski was introduced to cutting-edge live cell imaging technologies studying chemotaxis in the model system Dictyostelium discoideum. Dr. Brzostowski was recruited to LIG in 2005 to help establish a core imaging facility that would provide principal investigators, students, and fellows the capability to carry out sophisticated live cell imaging experiments. Dr. Brzostowski is an accomplished research scientist who is actively involved in training LIG staff in mastering imaging technologies in addition to carrying out his own research and collaborations.

See more about the LIG Imaging Facility.

Selected Publications

Martinez E, Brzostowski JA, Long EO, Gross CC. Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane. J Immunol. 2011 May 15;186(10):5538-42.

Xu X, Meckel T, Brzostowski JA, Yan J, Meier-Schellersheim M, Jin T. Coupling mechanism of a GPCR and a heterotrimeric G protein during chemoattractant gradient sensing in Dictyostelium. Sci Signal. 2010 Sep 28;3(141):ra71.

Gross CC, Brzostowski JA, Liu D, Long EO. Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization. J Immunol. 2010 Sep 1;185(5):2918-26.

Brzostowski JA, Fey P, Yan J, Isik N, Jin T. The Elmo family forms an ancient group of actin-regulating proteins. Commun Integr Biol. 2009 Jul;2(4):337-40.

Isik N, Brzostowski JA, Jin T. An Elmo-like protein associated with myosin II restricts spurious F-actin events to coordinate phagocytosis and chemotaxis. Dev Cell. 2008 Oct;15(4):590-602.

Fang J, Brzostowski JA, Ou S, Isik N, Nair V, Jin T. A vesicle surface tyrosine kinase regulates phagosome maturation. J Cell Biol. 2007 Jul 30;178(3):411-23.

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Last Updated October 26, 2012

Last Reviewed October 26, 2012