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AIDS Therapies Resource Guide

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Animal Pharmacology and Toxicology

This service can be used to provide pharmacokinetic and safety assessments of products in mice, rats, rabbits, dogs, and nonhuman primates.

They following types of studies can be conducted:

  • Quantitation of drug and metabolite levels in plasma
  • Determination of bioavailability and other pharmacokinetic parameters
  • Evaluation of products as substrates, inhibitors, or inducers of cytochrome P450 enzymes
  • In vitro genetic toxicity assessments (e.g., Ames test)
  • Determination of maximum tolerated dose
  • Determination of systemic and specific target-organ toxicity following single or multiple administrations of product
  • Studies can be conducted under GLP guidelines

The current contractor for this service is SRI International, Menlo Park, California.

Last Updated July 07, 2009