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AIDS Therapies Resource Guide

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Microbicides for the Prevention of HIV Transmission

In Vivo Efficacy Evaluations

This service provides evaluation of products in animal efficacy models. A product must demonstrate a potent and selective activity profile in the in vitro microbicide screening algorithm prior to its acceptance as a candidate for this service. Studies to determine optimal routes and schedules of drug administration can be performed.

Non-human Primate Model

  • Macaques are inoculated with SIV or SHIV.
  • Antiviral efficacy can be demonstrated via changes in virologic and immunologic parameters.

The current contractor for this service is Advanced BioScience Laboratories, Kensington, Maryland.

Last Updated July 07, 2009