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AIDS Therapies Resource Guide

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Microbicides for the Prevention of HIV Transmission

In Vivo Efficacy Evaluations

This service provides evaluation of products in animal efficacy models. A product must demonstrate a potent and selective activity profile in the in vitro microbicide screening algorithm prior to its acceptance as a candidate for this service. Studies to determine optimal routes and schedules of drug administration can be performed.

Non-human Primate Model

  • Macaques are inoculated with SIV or SHIV.
  • Antiviral efficacy can be demonstrated via changes in virologic and immunologic parameters.

The current contractor for this service is Advanced BioScience Laboratories, Kensington, Maryland.

NIAID’s point of contact for this service is Dr. Frosso Voulgaropoulou.

Last Updated July 07, 2009