Access DAPfinder and DAPview.
DAPfinder and DAPview are two novel plug-ins for BRB-ArrayTools that can be used to compare two coexpression networks constructed from microarray data. The DAPfinder tool re-constructs gene coexpression networks and identifies significant differences in pairwise gene-gene coexpression between two phenotypes. Each significant difference in gene-gene association is identified as a Differentially Associated Pair (DAP), which represents a significant change in the coexpression network between the two phenotypes. Several choices of filtering methods—gene-gene association metrics, statistical testing methods, and multiple comparison adjustments—are available to help users build and compare their networks. Network results from DAPfinder can be easily displayed in Cytoscape, while individual differences in pairwise gene coexpression can be visualized using DAPview.
DAPfinder and DAPview are provided free of charge by the National Institute of Allergy and Infectious Diseases.
NIAID Office of Cyber Infrastructure and Computational Biology created DAPfinder and DAPview.
Last Updated March 14, 2012
Last Reviewed March 14, 2012