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Centers of Excellence for Influenza Research and Surveillance (CEIRS)

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Mount Sinai School of Medicine: Center for Research on Influenza Pathogenesis (CRIP)

Babiuk S et al. 1918 and 2009 H1N1 influenza viruses are not pathogenic in birds. J Gen Virol 91:339-342.

Baum A et al. Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. Proc Natl Acad Sci U S A 107:16303-16308.

Medina RA et al. Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus. Nat Commun 1:1-6.

Mueller SN et al. Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses. J Virol 84:1847-1855.

Seibert CW et al. Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models. J Virol 84:11219-11226.

Steidle S et al. Glycine 184 in the non-structural protein NS1 determines virulence of influenza A virus strain PR8 without affecting the host interferon response.J Virol. doi:10.1128/JVI.00701-10.

Tscherne DM et al. An enzymatic virus-like particle assay for sensitive detection of virus entry. J Virol Methods 163:336-343.

Wang TT et al. Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proc Natl Acad Sci U S A doi: 10.1073/pnas.1013387107.

Widjaja I et al. Inhibition of the ubiquitin-proteasome system affects influenza A virus infection at a postfusion step. J Virol 84:9625-9631.

Zhou B et al. NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets. Vaccine. 2010 Nov 23;28(50):8015-25. Epub 2010 Oct 8.

Conenello G et al. A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo J Virol. 2011 Jan;85(2):652-62. Epub 2010 Nov 17.

Keawcharoen J et al. Repository of Eurasian influenza A virus hemagglutinin and neuraminidase reverse genetics vectors and recombinant viruses. Vaccine 28:5803-9 (2010).

Herfst S et al. Pandemic 2009 H1N1 influenza virus causes diffuse alveolar damage in Cynomolgus macaques. Vet Pathol. Jul 20. [Epub ahead of print] (2010).

Ye J et al. Intranasal delivery of an IgA monoclonal antibody effective against sub-lethal H5N1 influenza virus infection in mice. Clin Vaccine Immunol 17:1363-70 (2010).

Chutinimitkul S et al. Virulence-associated substitution D222G in hemagglutinin of 2009 pandemic influenza A (H1N1) virus affects receptor binding. J Virol. Sep 15. [Epub ahead of print] (2010).

Ye J et al. Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype? PLoS Pathog 6(10): e1001145.doi:10.1371/journal.ppat.1001145

Jianqiang Ye et al. Intranasal Delivery of an IgA Monoclonal Antibody Effective against Sublethal H5N1 Influenza Virus Infection in Mice. Clin Vaccine Immunol. Sept. p. 1363–1370.

Ye J et al. Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype? PLoS Pathog. 2010 Oct 14;6(10):e1001145. PMID: 20976194.

Pena L et al. Modifications in the polymerase genes of a swine-like triple reassortant influenza virus to generate live attenuated vaccines against 2009 pandemic H1N1 viruses. J Virol. 2010 Oct 20. [Epub ahead of print] PMID: 20962084.

Sorrell EM et al. A 27-Amino Acid Deletion in the NA Stalk Supports Respiratory Replication of an Avian H2N2 Influenza A virus in Chickens. J Gen Virol (2010) 91: 2485-2490.

Yamada S et al. Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathogens (2010) 6: e1001034.

Octaviani CP et al. High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses. J Virol (2010) 84: 10918-10922.

Kiso M et al. Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses. PLoS Pathogens (2010) 6: e1001079.

Sakabe A et al. A cross-reactive neutralizing monoclonal antibody protects mice from H5N1 and pandemic (H1N1) 2009 virus infection. Antiviral Res. 2010 Dec;88(3):249-55. Epub 2010 Sep 16.

Pearce JM et al. Interspecific exchange of avian influenza virus genes in Alaska: the influence of trans-hemispheric migratory tendency and breeding ground sympatry. Mol Ecol. 2010 Nov 12. doi: 10.1111/j.1365-294X.2010.04908.x. [Epub ahead of print]

Bui VN et al. Surveillance of Avian Influenza Virus in Migratory Water Birds in Eastern Hokkaido, Japan. Journal of Veterinary Medical Science. Epub 2010 Oct.

Mondloch D and Runstadler JA. Mx gene diversity and influenza association among five wild dabbling duck species (Anas spp.) in Alaska. Infection, Genetics, and Evolution Oct;10(7): 1085-93. Epub 2010 Jul 16.

Babiuk S et al..1918 and 2009 H1N1 influenza viruses are not pathogenic in birds. J Gen Virol 91:339-342.

Baum A et al. Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing. Proc Natl Acad Sci U S A 107:16303-16308.

Martinez-Sobrido L et al. Hemagglutinin-pseudotyped green fluorescent protein-expressing influenza viruses for the detection of influenza virus neutralizing antibodies. J Virol. 84:2157-2163.

Medina RA et al. Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus. Nat Commun 1:1-6.

Mueller SN et al. Immunization with live attenuated influenza viruses that express altered NS1 proteins results in potent and protective memory CD8+ T-cell responses. J Virol. 84:1847-1855.

Seibert CW et al. Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models. J Virol. 84:11219-11226.

Steidle S et al. Glycine 184 in the non-structural protein NS1 determines virulence of influenza A virus strain PR8 without affecting the host interferon response. J Virol. 2010 Dec;84(24):12761-70. Epub 2010 Oct 6.

Tscherne DM et al. An enzymatic virus-like particle assay for sensitive detection of virus entry. J Virol Methods 163:336-343.

Wang TT et al. Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18979-84. Epub 2010 Oct 18.

Widjaja I et al. Inhibition of the ubiquitin-proteasome system affects influenza A virus infection at a postfusion step. J Virol 84:9625-9631.

Zhou B et al. NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets. Vaccine. 2010 Nov 23;28(50):8015-25. Epub 2010 Oct 8.

Conenello GM et al. A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo. J Virol. 2010 Nov 17. [Epub ahead of print].

Keawcharoen J et al. Repository of Eurasian influenza A virus hemagglutinin and neuraminidase reverse genetics vectors and recombinant viruses. Vaccine 28:5803-9 (2010).

Herfst S et al. Pandemic 2009 H1N1 influenza virus causes diffuse alveolar damage in Cynomolgus macaques. Vet Pathol. Jul 20. [Epub ahead of print] (2010).

Ye J et al. Intranasal delivery of an IgA monoclonal antibody effective against sub-lethal H5N1 influenza virus infection in mice. Clin Vaccine Immunol 17:1363-70 (2010).

Chutinimitkul S et al. Virulence-associated substitution D222G in hemagglutinin of 2009 pandemic influenza A (H1N1) virus affects receptor binding. J Virol. Sep 15. [Epub ahead of print] (2010).

Ye J et al. Variations in the Hemagglutinin of the 2009 H1N1Pandemic Virus: Potential for Strains with Altered Virulence Phenotype? PLoS Pathog 6(10): e1001145.doi:10.1371/journal.ppat.1001145.

Pena L et al. Modifications in the polymerase genes of a swine-like triple reassortant influenza virus to generate live attenuated vaccines against 2009 pandemic H1N1 viruses. J Virol. 2010 Oct 20. [Epub ahead of print].

Sorrell EM et al. A 27-Amino Acid Deletion in the NA Stalk Supports Respiratory Replication of an Avian H2N2 Influenza A virus in Chickens. J Virol. 2010 Sep 8. [Epub ahead of print].

Le QM et al. Pathogenicity of highly pathogenic avian H5N1 influenza A viruses isolated from humans between 2003 and 2008 in northern Vietnam. Journal of General Virology (2010) 91: 2485-2490.

Yamada S et al. Biological and structural characterization of a host-adapting amino acid in influenza virus. PLoS Pathogens (2010) 6: e1001034.

Octaviani CP et al. High level of genetic compatibility between swine-origin H1N1 and highly pathogenic avian H5N1 influenza viruses. Journal of Virology (2010) 84: 10918-10922.

Kiso M et al. Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses. PLoS Pathogens (2010) 6: e1001079.

Sakabe A et al. A cross-reactive neutralizing monoclonal antibody protects mice from H5N1 and pandemic (H1N1) 2009 virus infection. Antiviral Res. 2010 Dec;88(3):249-55. Epub 2010 Sep 16.

Pearce JM et al. Interspecific exchange of avian influenza virus genes in Alaska: the influence of trans-hemispheric migratory tendency and breeding ground sympatry. Mol Ecol. 2010 Nov 12. doi: 10.1111/j.1365-294X.2010.04908.x. [Epub ahead of print].

Bui VN et al. Surveillance of Avian Influenza Virus in Migratory Water Birds in Eastern Hokkaido, Japan. J Vet Med Sci. 2010 Oct 8. [Epub ahead of print].

Mondloch D, Runstadler JA. Mx gene diversity and influenza association among five wild dabbling duck species (Anas spp.) in Alaska. Infect Genet Evol. 2010 Oct;10(7):1085-93. Epub 2010 Jul 16.

Versteeg GA, García-Sastre A. Viral tricks to grid-lock the type I interferon system. Curr Opin Microbiol. 2010 Jun 9. [Epub ahead of print]

Manicassamy B et al. Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus. Proc Natl Acad Sci U S A. 2010 Jun 7. [Epub ahead of print]

Varble A et al. Engineered RNA viral synthesis of microRNAs. Proc Natl Acad Sci U S A. 2010 Jun 7. [Epub ahead of print]

Perez JT et al. Influenza A virus-generated small RNAs regulate the switch from transcription to replication. Proc Natl Acad Sci U S A. 2010 Jun 1. [Epub ahead of print]

Ramirez-Nieto G et al. Adaptation of a mallard H5N2 low pathogenicity influenza virus in chickens with prior history of infection with infectious bursal disease virus. Avian Dis. 2010 Mar;54(1 Suppl):513-21.

Fouchier RA, Smith DJ. Use of antigenic cartography in vaccine seed strain selection. Avian Dis. 2010 Mar;54(1 Suppl):220-3.

Munster VJ et al. Insertion of a multi basic cleavage motif into the hemagglutinin of a low pathogenic avian influenza H6N1 virus induces a highly pathogenic phenotype. J Virol. 2010 Jun 2. [Epub ahead of print]

Gao Q et al. A nine-segmented influenza A virus carrying H1 and H3 subtype hemagglutinins. J Virol. 2010 Jun 2. [Epub ahead of print]

Versteeg GA et al. Species-specific antagonism of host ISGylation by the influenza B virus NS1 protein. J Virol. 2010 May;84(10):5423-30. Epub 2010 Mar 10.

Ranjan P et al. 5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication. Virol J. 2010 May 21;7(1):102. [Epub ahead of print]

Nistal-Villan E. Negative role of RIG-I serine 8 phosphorylation in the regulation of IFN-{beta} production. J Biol Chem. 2010 Apr 20. [Epub ahead of print]

Wang TT et al. Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins. PLoS Pathog. 2010 Feb 26;6(2):e1000796.

Hale BG et al. Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein. J Virol, July 2010, p. 6909-6922, Vol. 84, No. 14

Hale BG et al. Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus. J Gen Virol 91 (2010), 1737-1742; DOI 10.1099/vir.0.020925-0.

Hai R et al. PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models. J Virol. May 2010, p. 4442-4450, Vol. 84, No. 9.

Solórzano A et al. Alternative live-attenuated influenza vaccines based on modifications in the polymerase genes protect against epidemic and pandemic flu. J Virol. 2010 Feb 24. [Epub ahead of print].

Herfst S et al. Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission. J Virol. 2010 Feb 3. [Epub ahead of print]

Nayak B et al. Contributions of the Avian Influenza Virus HA, NA, and M2 Surface Proteins to the Induction of Neutralizing Antibodies and Protective Immunity. J Virol. 2010 Mar;84(5):2408-20. Epub 2009 Dec 23.

Siembieda JL et al. Influenza A Viruses in Wild Birds of the Pacific Flyway, 2005-2008. Vector Borne Zoonotic Diseases. 2010 Jan 8. Epub ahead of print. (this paper based on CEIRS supported research through CRISAR)

Hill JH et al. Waterfowl Ecology and Avian Influenza in California: Do Host Traits Inform Us About Viral Occurrence? Avian Diseases 2010 54: 426-432. (this paper based on CEIRS supported research through CRISAR)

Gannagé M et al. Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes. Cell Host & Microbe. 6(4):367-80. PMID: 19837376.

Steel J et al. Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment. J Virol. Oct 14. [Epub ahead of print]. PMID: 19828604.

Munster VJ et al. Avian influenza virus: Of virus and bird ecology. Vaccine. 2009 Oct 23;27(45):6340-4.

Fouchier RA et al. Epidemiology of low pathogenic avian influenza viruses in wild birds. Rev Sci Tech. 2009 Apr;28(1):49-58.

Munster VJ et al. Pathogenesis and transmission of swine-origin 2009 A (H1N1) influenza virus in ferrets. Science. 2009 Jul 24;325(5939):481-3.

Meijer A et al. Preparing the outbreak assistance laboratory network in the Netherlands for the detection of the influenza virus A (H1N1) variant. J Clin Virol. 2009 Jul;45(3):179-84.

Sorrell E et al. Fitness of Pandemic H1N1 and Seasonal influenza A viruses during Co-infection. PLoS Currents: Influenza. 2009 Aug 25 [revised 2009 Aug 27]:RRN1011.

Song H et al. Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity. Virol J. 2009 Aug 14;6(1):126. [Epub ahead of]

Nayak B et al. Immunization of Chickens with Newcastle Disease Virus Expressing H5 Hemagglutinin Protects against Highly Pathogenic H5N1 Avian Influenza Viruses. PLoS ONE 2009 4(8): e6509. doi:10.1371/journal.pone.0006509.

Itoh Y et al. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 460:1021-1025.

Lavoie ET et al. Immunosenescence and age-related susceptibility to influenza virus in Japanese quail.
Dev Comp Immunol. 2007;31(4):407-14. Epub 2006 Sep 20.

Gack MU et al. Influenza A virus targets the ubiquitin ligase TRIM25 to evade recognition by RIG-I. Cell Host Microbe. 2009 May 8;5(5):439-49.

Lowen AC et al. High temperature (30 degrees C) blocks aerosol but not contact transmission of influenza virus. J Virol 82, 5650-5652.

Mubareka S et al. (2009). Transmission of Influenza Virus via Aerosols and Fomites in the Guinea Pig Model. J Infect Dis.

de Wit E et al. Pathogenesis of highly pathogenic avian influenza virus in mammals. Vaccine, 26S:D54-8 (2008).

Russell CA et al. Influenza vaccine strain selection and recent studies on the global migration of seasonal influenza viruses. Vaccine 26S:D31-4 (2008).

Munster VJ et al. Practical considerations for high-throughput influenza A virus surveillance studies of wild birds by use of molecular diagnostic tests. J Clin Microbiol. 47:666-73 (2009).

Sorrell EM et al. Minimal molecular constraints for respiratory droplet transmission of an avian–human H9N2 influenza A virus. PNAS published online before print April 20, 2009, doi:10.1073/pnas.0900877106.

Xing Z et al. Differential regulation of antiviral and proinflammatory cytokines and suppression of Fas-medaited apoptosis by NS1 of H9N2 avian influenza virus in chicken macrophages. J Gen Virol. 2009 Mar 4.

Steel et al. Live Attenuated Influenza Viruses Containing NS1 Truncations as Vaccine Candidates against H5N1 HPAI. J Virol. 2008 Dec 10.

Wan H et al. Replication and transmission of H9N2 influenza viruses in ferrets: evaluation of pandemic potential. PLoS ONE. 2008 Aug 13;3(8):e2923. PMID: 18698430.

Pereda AJ et al. Avian influenza virus isolated in wild waterfowl in Argentina: Evidence of a potentially unique phylogenetic lineage in South America. Virology. 2008 Sep 1;378(2):363-70. Epub 2008 Jul 15. PMID: 18632129.

Jackson D et al. A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4381-6. Epub 2008 Mar 11. PMID: 18334632

Haye K et al. The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells. J Virol. doi:10.1128/JVI.02323-08

Steel J et al. Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza. J Virol. 2009 Feb;83(4):1742-53. Epub 2008 Dec 10.

Lowen AC et al. Blocking inter-host transmission of influenza virus by vaccination in the guinea pig model. J Virol. 2009 Jan 19. [Epub ahead of print]

Hoffmann HH et al. Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity. Antiviral Res. 2008 Nov;80(2):124-34. Epub 2008 Jun 13.

Hickman D et al. An avian live attenuated master backbone for potential use in epidemic and pandemic influenza vaccines.
J Gen Virol. 2008 Nov;89(Pt 11):2682-90.

Bouvier NM et al. Oseltamivir-resistant influenza A viruses are transmitted efficiently among guinea pigs by direct contact but not by aerosol. J Virol. 2008 Oct;82(20):10052-8. Epub 2008 Aug 6.

Hossain MJ et al. Evidence of expanded host range and mammalian-associated genetic changes in a duck H9N2 influenza virus following adaptation in quail and chickens. PLoS ONE. 2008 Sep 9;3(9):e3170.

Hai R et al. Influenza B virus NS1-truncated mutants: live-attenuated vaccine approach. J Virol. 2008 Nov;82(21):10580-90. Epub 2008 Sep 3.

Hoffmann HH et al. Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity. Antiviral Res. 2008 Nov;80(2):124-34. Epub 2008 Jun 13.

Gao Q et al. A seven-segmented influenza A virus expressing the influenza C virus glycoprotein HEF. J Virol. 2008 Jul;82(13):6419-26. Epub 2008 Apr 30.

Russell CA et al. The global circulation of seasonal influenza A (H3N2) viruses. Science. 2008 Apr 18;320(5874):340-6.

Marsh GA et al. Highly conserved regions of influenza a virus polymerase gene segments are critical for efficient viral RNA packaging. J Virol. 2008 Mar;82(5):2295-304. Epub 2007 Dec 19.

Conenello GM et al. A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence. PLoS Pathog. 2007 Oct 5;3(10):1414-21.

Marsh GA et al. Specific residues of the influenza A virus hemagglutinin viral RNA are important for efficient packaging into budding virions. J Virol. 2007 Sep;81(18):9727-36. Epub 2007 Jul 18.

Sorrell EM et al. Adaptation of influenza A/Mallard/Potsdam/178-4/83 H2N2 virus in Japanese quail leads to infection and transmission in chickens. Avian Dis. 2007 Mar;51(1 Suppl):264-8.

Wan H et al. Amino acid 226 in the hemagglutinin of H9N2 influenza viruses determines cell tropism and replication in human airway epithelial cells. J Virol. 2007 May;81(10):5181-91. Epub 2007 Mar 7.

Wang TT, Palese P. Universal epitopes of influenza virus hemagglutinins? Nat Struct Mol Biol. 2009 Mar;16(3):233-4. Epub 2009 Feb 22.

Solorzano A et al. Pandemic influenza: preventing the emergence of novel strains and countermeasures to ameliorate its effects. Infect Disord Drug Targets. 2007 Dec;7(4):304-17.

Tsibane T et al. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines. PLoS Pathog. 2010 Jan 29;6(1):e1000745.

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Last Updated March 02, 2011

Last Reviewed May 14, 2010