Resources for Researchers

Microbiology and Infectious Diseases Resources—Therapeutics

Discovery and IND (Investigational New Drug)-Enabling Activities

Develop targets

• Genome sequencing
• Identify protein biomarkers
• Data and analysis
• Structural genomics
• Systems biology

Assess in vitro antimicrobial activity

Assess activity in vivo

Identify and verify targets

Identify and optimize; synthesize; and characterize lead candidates

Formulate lead candidates

Develop preclinical planning and evaluation

Assess immunogenicity

Evaluate toxicology

Evaluate pharmacokinetics

Refine animal models

Chemistry and manufacturing

Evaluate genotoxicity

Evaluate safety pharmacology