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NIAID Bioinformatics Resource Centers Award Nine New Driving Biological Projects in 2012

The NIAID Bioinformatics Resource Centers (BRCs) have made nine two-year awards in 2012 to establish Driving Biological Projects (DBPs). The DBPs are designed to promote close cooperation between bioinformatics specialists and experimental biologists and to stimulate cooperation on data analysis, visualization and development of new bioinformatics tools.

These projects focus on infectious diseases research related to human pathogens and vectors of infectious diseases. Research includes the use of high-throughput experimental technologies (HTP) to functionally characterize the genome, proteome or metabolome of pathogenic organisms or vectors of pathogens, and/or host-pathogen/vector interactions. This research may help elucidate the role of genes, proteins and metabolites with respect to pathogenesis, antimicrobial resistance or other biological processes of interest. The data and information generated by the DBPs will be made accessible to the broad scientific community and will be used to drive BRC’s infrastructure development to enable other researchers to perform similar analyses at the BRC websites using their own data.

The BRCs solicited proposals for the DBPs through an open competition. All proposals were reviewed by the Scientific Working Group of each BRC who serves as a steering committee of external scientific experts. Recommendations for the awards were made to NIAID based on technical feasibility, scientific merit, innovation, and impact on BRC development.


The awards have been distributed among the four BRCs. Each listing includes the principal investigator(s), affiliation, and proposal title:
    EuPathDB BRC
    • Hendrik Stunnenberg (Radboud University) and Richard Bartfai (University of Nijmegen): Placing the Plasmodium falciparum epigenome on the map.
    • Adrian Hehl, Michael Grigg and Nicholas Smith (University of Zurich): Sexual Development in Toxoplasma: High-Throughput Functional Genomics & Proteomics.
    • Scott Dawson (University of California, Davis): High throughput 3D localization of 960 candidate cytoskeletal and organelle-associated proteins in Giardia intestinalis.
    • Joseph Wade (Wadsworth Center, University at Albany, State University of New York): Identification of Salmonella-specific Regulatory Networks.
    • Jon McCullers and Jason Rosch (St. Jude Children’s Research Hospital): Integrated genomic approaches to elucidating novel virulence factors for bacteria complicating influenza
    VectorBase BRC
    • Catherine A. Hill (Purdue University): RAD Sequencing of SNPs in the Ixodes scapularis.
    • Jaroslaw Krzywinski (Liverpool School of Tropical Medicine): 2. Ultra-deep exploration of transcription in Anopheles gambiae.
    ViPR BRC
    • Richard J. Kuhn and Catherine A. Hill (Purdue University): Functional metabolomics of dengue virus infection in the human host and mosquito vector – a novel avenue for antiviral target discovery.
    • Michael S. Diamond (Washington University): Mechanisms of interferon control of flaviviruses and norovirusese

Last Updated December 17, 2012