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NIAID Structure of the Month

MbtH protein Rv2377c

The December Structure of the Month comes from Mycobacterium tuberculosis, the pathogenic bacterial species that is the causative agent of most cases of tuberculosis. The depicted structure represents the protein Rv2377c.

Protein Rv2377c structure
The protein Rv2377c structure was determined by the Seattle Structural Genomics Center for Infectious Diseases.

Rv2377c is the founding member of the MbtH family of proteins that are located in a cluster of genes involved in nonribosomal peptide synthesis of mycobactin. While the precise biological function of Rv2377c and other MbtH-like proteins remain unknown, their association with siderophore biosynthesis has identified these proteins as a target for antibiotic development because siderophores are crucial to iron regulation in the bacterium after infection.

For more information please see the Seattle Structural Genomics Center for Infectious Diseases.

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Last Updated March 02, 2011