Skip Navigation
Leading research to understand, treat, and prevent infectious, immunologic, and allergic diseases
Skip Website Tools
Skip Content Marketing
  • Share this:
  • submit to facebook
  • Tweet it
  • submit to reddit
  • submit to StumbleUpon
  • submit to Google +

Mycobacterium tuberculosis: Ras-like Transport Protein

This protein from M. tuberculosis is a member of the Ras superfamily of proteins. The Ras superfamily encompasses more than 100 proteins, which are generally involved in signal transduction. Activating mutations in human Ras are associated with many types of cancer.

While originally annotated as an arginine/ornithine transport system ATPase, researchers found that the protein is most likely a GTPase based on guanosine-5'-triphosphate bound to the structure. The structure of the GTPase domain of the protein is similar to that of human Ras and several amino acids that line the GTP binding pocket are conserved.

The structure is related in sequence and structure to the methylmalonic acidemia type A protein (PDB ID 2WWW), a protein which is responsible for a potentially fatal metabolic disorder in humans.

For more information, please see the Protein Data Bank entry 3MD0.

This structure was determined by the Seattle Structural Genomics Center for Infectious Diseases.

Image of M. tuberculosis Ras protein 


All featured structures from the NIAID Structural Genomics Centers​​​​

Last Updated June 01, 2010