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NIAID Structure of the Month

November 2009: Vibrio cholerae toxin

B. pseudomallei enzyme
The Center for Structural Genomics of Infectious Diseases has determined this 3-D enzyme structure from a Vibrio cholerae toxin.

This month's highlight is from a Vibrio cholerae toxin. The gastrointestinal pathogen V. cholerae is the bacteria responsible for causing cholera in humans.

Its Multifunctional Autoprocessing Repeats-in-ToXin toxin (MARTX) is related to other bacterial toxins, including those produced by at least 9 different Gram-negative bacteria, such as emerging hospital-acquired infections due to Clostridium difficile.

Information for researchers about the toxin protease structure can be found at the CSGID structure summary.

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Last Updated March 02, 2011