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NIAID Structure of the Month

2’-O-methyl RNA methyltransferase

B. pseudomallei enzyme
The Seattle Structural Genomics Center for Infectious Diseases has determined this 3-D enzyme structure from Burkholderia pseudomallei.

The product of this enzyme is one of the most common ways bacteria can obtain antibiotic resistance. An interesting aspect of this enzyme from Burkholderia pseudomallei is that it contains a 31 (trefoil) protein knot. The thread of the knot can be seen in orange-red at the bottom of the ribbon structure.

There are only 40 other known protein structures that contain similar knots. This knot is quite different even from more classical enzymes in this class of methyltransferases.

An additional interesting feature is that unlike other RNA methyltransferases this RNA methyltransferase does not contain an RNA binding domain, suggesting it may bind an accessory protein, or perhaps a different or altered substrate.

For more information, please see the Protein Data Bank entry 3e5y

This structure was determined by the Seattle Structural Genomics Center for Infectious Diseases

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Last Updated March 02, 2011