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Structural Genomics Centers for Infectious Diseases

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Structure of the Month

2009 H1N1 Influenza – NS1 Protein

The nonstructural protein NS1 is employed by influenza viruses to evade host immune responses. Several studies have implicated the NS1 protein in conferring increased pathogenicity and virulence on emergent influenza strains. The NS1 virulence factor is believed to participate in multiple host-cell interactions regulating processes as diverse as viral replication, host innate and adaptive immunity, and cellular signaling. The NS1 protein consists of a N-terminal RNA-binding domain and a C-terminal protein-binding "effector" domain. The protein is being studied both for its potential in vaccine development and for its potential in antiviral drug design.

The Center for Structural Genomics of Infectious Diseases, CSGID, has determined the 3D structure of both the N-terminal and the C-terminal domains of the NS1 protein from H1N1 Influenza A/California/07/2009. For more information see 3M8A and 3M5R, respectively or IDP90271.


C-terminal protein-binding "effector" domain. Courtesy of the CSGID.

 


N-terminal RNA-binding domain. Courtesy of the CSGID.

Past Features

Last Updated April 27, 2010

Last Reviewed April 27, 2010