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Structure of the Month

Burkholderia pseudomallei protein: xadA Trimeric Autotransporter Adhesin Head

Adhesion of the pathogen to the host is a crucial first step in infection. The structure presented here plays just such a role. It is the head domain of protein xadA Trimeric Autotransporter Adhesin (TAA) from Burkholderia pseudomallei. This pathogen is not only a potential bioterror agent but also causes melioidosis, which results in skin infections, chest, bone and joint pain, cough, lung nodules and enables contraction of pneumonia.

The importance of this protein for pathogen virulence, combined with its close association with the pathogen cell membrane (where it is more accessible), make it a potential target for drug development For more information, please see the Protein Data Bank entries 3la9 and 3laa.

 

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Last Updated March 02, 2011