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Structure of the Month: Toxoplasma gondii Enolase

Enolases catalyze one of the reactions of the central glycolytic pathway. However, they also have other functions in the cell, including being involved in the regulation of gene expression.

The eukaryotic parasite Toxoplasma gondii has two enolase genes that are expressed at different stages in its life cycle. The Center for Structural Genomics of Infectious Diseases (CSGID) has determined the structure of the Toxoplasma enolase 1 (PDB code 3OTR, orange in the figure), that is expressed when the parasite forms cysts in the brain.

The Toxoplasma enolase is shown superimposed on the human neuron specific enolase (PDB code 1TE6, cyan in the figure). In general, the two structures are very similar. However they do have differences in the loops of protein around the central active site and between the regulatory domain (upper right) and the enzymatic domain.

 

T. gondii enolase structure
The CSGID determined this enolase gene structure.from T. gondii, the parasite responsible for toxoplasmosis.

 

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Last Updated March 02, 2011

Last Reviewed October 04, 2010