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AD4H5VTN Vaccine Studies

About the study

Researchers at the National Institutes of Health (NIH) are testing an investigational vaccine for a virus that typically causes symptoms seen in the common cold and flu. The goal of this research study is to learn whether the vaccine is safe, causes a strong immune response, and prevents the virus from spreading to others. This will help researchers develop vaccines for common illnesses.

Who can participate?

You may be eligible for the study if you

  • Are 18 to 49 years old and in good health
  • Are willing to stay at NIH for up to one week
  • Do not live or work closely with
    • People who have weakened immune systems caused by chronic illness
    • Children younger than 3 years old
    • Elderly people
    • Pregnant women

What does the study involve?

Participants will be asked to visit the NIH Clinical Center in Bethesda, Maryland, for a blood draw, medical history, and physical exam. Participants will return to NIH to receive the investigational vaccine, which will be given in the back of the throat or as a pill. Participants will need to stay at NIH for up to one week for monitoring. Individuals in close contact with participants may also need to visit NIH; however, they will not receive the vaccine.

Where is the study taking place?

The study is being conducted at the Warren Grant Magnuson Clinical Center (Building 10) on the NIH campus in Bethesda, Maryland. The NIH campus is accessible by car and public transportation.

How much does it cost?

There is no charge to participate in the study. All screening and study-related medical care and procedures are provided free of charge.

Will I receive payment?

Yes, you and any close contacts will be compensated for participation in the study. Transportation and other expenses may also be covered.

How do I find out more or volunteer?

To see if you may qualify or for more information, contact

Patient Recruitment and Public Liaison Office
Toll Free: 1-800-411-1222 (reference 11-I-0259/SAMOSA study or 13-I-0081/NAAN study)
TTY: 1-866-411-1010
Se habla español
Office hours: 8:00 a.m. – 3:30 p.m. Eastern Time

To learn more about this study of intranasal AD4-H5-VTN as an adenovirus vaccine (trial ID: NCT01806909), please visit

Last Updated August 21, 2013