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Biostatistics Research Branch (BRB)

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Dean Follmann, Ph.D.

Chief, Biostatistics Research Branch, DCR


Development of novel statistical methodology based on applied problems.

Additional Information

Curriculum Vitae (PDF)

Selected Statistical Publications

Huang CY, Qin J, Follmann DA. (2008). Empirical Likelihood-Based Estimation of Treatment Erect in a Pretest-Posttest Study, Journal of the American Statistical Association 103,1270-1280.

Hu Z, Qin J, Follmann DA. (2008) Semiparametric Two-sample Change-point Model with Application in HIV Studies, JRSS-C: Applied Statistics 57, Part 5, 589–607.

Hu Z, Qin J,Follmann DA, Dewar R, Sangweni P. (2008). A Nonparametric Likelihood Approach for Detecting the Discordance of Two Measurements with Limit of Detection, Statistics in Medicine, 27, 4489–4501.

Proschan MA, Follmann DA. (2008). Cluster Without Fluster: The Effect of Correlated Outcomes on Inference in Randomized Clinical Trials, Statistics in Medicine 27, 795-809.

Brittain E, Follmann DA,  Song Y. Dynamic Comparison of Kaplan-Meier Pro-portions: Monitoring a Randomized Clinical Trial with a Long Term Binary Endpoint, Biometrics (2008); 64: 189-197.

Qin L, Gilbert P, Follmann DA Li D. (2008). Assessing Surrogate Endpoints in Vaccine Trials with Case-Cohort Sampling and the Cox Model Annals of Applied Statistics 1, 386-407

Albert PS, Follmann DA. (2007). Random Effects and Latent Processes Approaches for Analyzing Binary Longitudinal Data with Missingness: A Comparison of Approaches Using Opiate Clinical Trial Data, Statistical Methods for Medical Researchers 16, 417-439

Fay MP, Halloran ME, Follmann DA.(2007). Accounting for Variability in Sample Size Es-timation with Applications to Nonadherence and Estimate of Variance and Effect Size, Biometrics 63, 465-474.

Hu Z., Follmann DA. (2007). Statistical Methods for Active Extension Trials, Statistics in Medicine 26, 2433-2448.

Follmann DA. (2006). Augmented Designs to Assess Immune Response in Vaccine Trials, Biometrics 62, 1161-1169.

Proschan MA, Follmann DA. (2004). ”A Permutation Approach To The Behrens-Fisher Problem”. Journal of the Korean Statistical Society 33, 79-97.

Stylianou M, Follmann DA. (2004). The Accelerated Biased Coin Up-and-Down Design in Phase I Trials. Journal of Biopharmaceutical Statistics 14, 249-260.

Wu CO, Zheng G et al (2003). A Statistical Method for Adjusting Covariates in Linkage Analysis with Sib Pairs. BMC Genetics 4(Suppl 1), S51.

Follmann DA, Proschan MA, and Leifer E. (2003). Multiple Outputation: Inference for Complex Clustered Data by Averaging Analyses from Independent Data. Biometrics 59, 420-429.

Follmann DA. (2003). Comparing HLA Antigen Frequencies Between Two Groups of Patients. Statist Med 22, 1999-2013.

All Dean Follmann Statistical Publications

Selected Medical Publications

Migueles SA, Osborne CM, Royce C, Compton AA, Joshi RP, Weeks KA, Rood JE, Berkley AM, Sacha JB, Cogliano-Shutta NA, Lloyd M,Roby G, Kwan R, McLaughlin M, Stallings S, Rehm C, O'Shea MA, Mican J, Packard BZ, Komoriya A, Palmer S, Wieg and AP, Maldarelli, F., Coin JM, Mellors JW, Hallahan CW, Follman DA, Connors M Lytic Granule Loading of CD8(+) T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control, Immunity, 2008; 29 1009-1021.

Catalfamoa M,Di Mascio M, Hu Z, Srinivasula S, Thakera V, Adelsbergerd J, Rupert A, Baseler M, Tagaya Y, Roby G, Rehm C, Follmann DA, & Lane, HC/HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells, Proceedings of the National Academy of Sciences 2008; 105 19851-19856.

Fogli M, Mavilio D, Brunetta E, Varchetta S, Ata K, Roby G, Kovacs C, Follmann DA, Pende D, Ward J, Barker E, Marcenaro E, Moretta A, & Fauci AS, Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV- infected viremic individuals PLoS Pathogens 2008; 4 1000101; 1-12.

Melenhorst J, Lay M, Price D, Adams S, Zeilah J, Sosa E, Hensel N, Follmann DA, Douek D, Davenport M, Barrett J, Relative contribution of T cell receptor-beta locus factors and HLA in the shaping of the mature human Vbeta repertoire, Journal of Immunology 2008; 180(10) 6484-6489.

Hoshino Y, Qin, J, Follmann D, Strauss S, Cohen J The number of herpes simplex virus-infected neurons and the number of viral genome copies per neuron correlate with the latent viral load in ganglia, Virology 2008; 372 56-63.

Lopez-Granados E, Temmerman S, Wu L, Reynolds JC, Follmann D, Liu S, Rauch F, Jain A, Osteopenia in X-linked Hyper-IgM syndrome reveals a regulatory role for CD40 ligand inosteoclastogenesis, Proceedings of the National Academy of Sciences 2007; 104; 5056-5061.

Follmann DA, Duerr A, Tabet S, Gilbert P, Moodie Z, Cardinalli M, Self S. Endpoints and Regulatory Issues in HIV Vaccine Clinical Trials: Lessons from a Workshop, Journal of Acquired Immune Deficiency Syndrome 2007; 44; 49-60.

Mavilio D, Lombardo G, Kinter A, Fogli M, La Sala A, Ortolano S, Farschi A, Follmann, DA, Gregg R, Kovacs C, Marcenaro E, Pende D, Moretta A, Fauci A. A Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection, Journal of Experimental Medicine, 2006; 203 (10) 2339-2350.

Kim Yea-Jean, Kumaraswami V, Choi Eun Hwa, Mu JB, Follmann DA, Zimmerman P, Nutman TB, Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia, American Journal of Tropical Medicine and Hygiene 2005; 73 (1): 125-130.

Malaspina A., Moir S., Orsega S, Vasquez J, Miller N, Donoghue E, Kottilil S, Gezmu M, Follmann DA, Galina M, Vodeiko G, Levandowski R, Mican J,  Fauci A. A. Compromised B Cell Responses to Influenza Vaccination in HIV-Infected Individuals, Journal of Infectious Diseases 2005; 191 1442-1450.

Gilbert PB, Peterson ML, Follmann DA, Hudgens MG, Francis DP, Gurwith M, Heyward WL, Jobes DV, Popovic V, Self SG, Sinangil F, Burke D, Berman PW. Correlation between Immunologic Responses to a Recombinant Glycoprotein 120 Vaccine and Incidence of HIV-1 Infection in a Phase 3 HIV-1 Preventive Vaccine Trial, Journal of Infectious Diseases 2005; 191 666-677.

Mavilio D, Lombardo G, Benjamin J, Kim D, Follmann DA, Marcenaro E, Planta M, Turney J, Kovacs C, Moretta A, Fauci AS. Characterization of CD56neg/CD16pos Natural Killer Cells: a Highly Dysfunctional NK Subset expanded in HIV infected viremic individuals, Proceedings of the National Academy of Sciences, 2005; 102 (8): 2886-2891.

All Dean Follmann Medical Publications

Recent Talks

Multiple Outputation: A Permutation Approach to Complex Correlated Data

Augmented designs to assess immune response in vaccine trials

Composite Endpoints

An Independent Analysis of the Effect of Race in VAX004
(Tuesday) Feb. 10, 2004

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Last Updated November 24, 2010