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Division of Microbiology and Infectious Diseases (DMID)

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Enteric Research Investigational Network

NIAID has awarded four grants to establish the Enteric Research Investigational Network (ERIN), which is designed to bridge gaps between basic and clinical research on bacteria and viruses that gain access to the host via the gastrointestinal tract to cause a variety of diseases.

Infections with enteric pathogens, caused by both bacteria and viruses, can produce disease symptoms ranging from mild gastroenteritis to life-threatening dehydrating diarrhea. Furthermore, some enteric pathogens have the capacity to cause disease far from the initial site of infection, including serious, long term neurological or musculoskeletal complications. The World Health Organization estimates that diarrheal diseases, including those due to enteric pathogens, cause approximately 2.2 million deaths each year, primarily among infants and young children. The bacteria to be studied by the ERIN sites include Escherichia coli, Campylobacter jejuni, Clostridium difficile, and multiple species of Shigella and Salmonella.

Interdisciplinary research at each ERIN component will encompass both basic and clinical research on topics such as

  • Basic biology and ecology of the disease-causing microbes
  • How the human host responds to infection
  • Clinical research and use of clinical samples to elucidate mechanisms of human infection, disease, and immunity

The following institutions comprise ERIN:

  • Michigan State University; Principal investigator: Linda Mansfield, Ph.D.
  • University of Maryland; Principal investigator James Kaper, Ph.D.
  • University of Michigan, Ann Arbor; Principal investigator: Vincent Young, M.D., Ph.D.
  • University of Washington; Principal investigator: Samuel Miller, M.D.

Last Updated June 02, 2011

Last Reviewed June 02, 2011