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Vaccine Research Center Journal Publications, 2006

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Journal of Allergy and Clinical Immunology
Smallpox vaccines: Past, present, and future.
Parrino J, Graham BS.
J Allergy Clin Immunol. 2006 Dec;118(6):1320-6.

Proceedings of the National Academy of Sciences of the United States of America
Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates.
Messaoudi I, Warner J, Fischer M, Park B, Hill B, Mattison J, Lane MA, Roth GS, Ingram DK, Picker LJ, Douek DC, Mori M, Nikolich-Zugich J.
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19448-53. Epub 2006 Dec 11.

The Journal of Experimental Medicine
Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation.
Casazza JP, Betts MR, Price DA, Precopio ML, Ruff LE, Brenchley JM, Hill BJ, Roederer M, Douek DC, Koup RA.
J Exp Med. 2006 Dec 25;203(13):2865-77. Epub 2006 Dec 11.


Journal of Acquired Immune Deficiency Syndromes
Novel approach for differential diagnosis of HIV infections in the face of vaccine-generated antibodies: utility for detection of diverse HIV-1 subtypes.
Khurana S, Needham J, Park S, Mathieson B, Busch MP, Nemo G, Nyambi P, Zolla-Pazner S, Laal S, Mulenga J, Chomba E, Hunter E, Allen S, McIntyre J, Hewlett I, Lee S, Tang S, Cowan E, Beyrer C, Altfeld M, Yu XG, Tounkara A, Koita O, Kamali A, Nguyen N, Graham BS, Todd D, Mugenyi P, Anzala O, Sanders E, Ketter N, Fast P, Golding H.
J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):304-12.

Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax((R)) challenge in vaccinia-naive and vaccinia-immune individuals.
Parrino J, McCurdy LH, Larkin BD, Gordon IJ, Rucker SE, Enama ME, Koup RA, Roederer M, Bailer RT, Moodie Z, Gu L, Yan L, Graham BS; VRC 201/203 Study Team.
Vaccine. 2006 Nov 7; [Epub ahead of print]

Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs.
Shu Y, Winfrey S, Yang ZY, Xu L, Rao SS, Srivastava I, Barnett SW, Nabel GJ, Mascola JR.
Vaccine. 2006 Nov 7; [Epub ahead of print]

The Journal of Infectious Diseases
Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1 Candidate Vaccine Delivered by a Replication-Defective Recombinant Adenovirus Vector.
Catanzaro AT, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie Z, Gu L, Martin JE, Novik L, Chakrabarti BK, Butman BT, Gall JG, King CR, Andrews CA, Sheets R, Gomez PL, Mascola JR, Nabel GJ, Graham BS; Vaccine Research Center 006 Study Team.
J Infect Dis. 2006 Dec 15;194(12):1638-49. Epub 2006 Nov 8.

The Journal of Infectious Diseases
Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1 DNA Candidate Vaccine.
Graham BS, Koup RA, Roederer M, Bailer RT, Enama ME, Moodie Z, Martin JE, McCluskey MM, Chakrabarti BK, Lamoreaux L, Andrews CA, Gomez PL, Mascola JR, Nabel GJ; Vaccine Research Center 004 Study Team.
J Infect Dis. 2006 Dec 15;194(12):1650-60. Epub 2006 Nov 8.

Journal of Virology
Lysis of HIV-1 by a Specific Secreted Human Phospholipase A2.
Kim JO, Chakrabarti B, Guha-Niyogi A, Louder MK, Mascola JR, Ganesh L, Nabel GJ.
J Virol. 2006 Nov 8; [Epub ahead of print]

Journal of Acquired Immune Deficiency Syndromes
Phase 2 Study of an HIV-1 Canarypox Vaccine (vCP1452) Alone and in Combination With rgp120: Negative Results Fail to Trigger a Phase 3 Correlates Trial.
Russell ND, Graham BS, Keefer MC, McElrath MJ, Self SG, Weinhold KJ, Montefiori DC, Ferrari G, Horton H, Tomaras GD, Gurunathan S, Baglyos L, Frey SE, Mulligan MJ, Harro CD, Buchbinder SP, Baden LR, Blattner WA, Koblin BA, Corey L; the National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network.
J Acquir Immune Defic Syndr. 2006 Nov 9; [Epub ahead of print]

Proceedings of the National Academy of Sciences of the United States of America
Gene transfer in humans using a conditionally replicating lentiviral vector.
Levine BL, Humeau LM, Boyer J, Macgregor RR, Rebello T, Lu X, Binder GK, Slepushkin V, Lemiale F, Mascola JR, Bushman FD, Dropulic B, June CH.
Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17372-7. Epub 2006 Nov 7.

Journal of Virology
The ERK Mitogen-Activated Protein Kinase Pathway Contributes to Ebola Glycoprotein-Induced Cytotoxicity.
Zampieri CA, Fortin JF, Nolan GP, Nabel GJ.
J Virol. 2006 Nov 15; [Epub ahead of print]

Nature Medicine
Microbial translocation is a cause of systemic immune activation in chronic HIV infection.
Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, Kazzaz Z, Bornstein E, Lambotte O, Altmann D, Blazar BR, Rodriguez B, Teixeira-Johnson L, Landay A, Martin JN, Hecht FM, Picker LJ, Lederman MM, Deeks SG, Douek DC.
Nat Med. 2007 Jan;12(12):1365-1371. Epub 2006 Nov 19.

Modern Pathology
The histopathology of fatal untreated human respiratory syncytial virus infection.
Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS.
Mod Pathol. 2006 Nov 24; [Epub ahead of print]

Proceedings of the National Academy of Sciences of the United States of America
Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination.
Venturi V, Kedzierska K, Price DA, Doherty PC, Douek DC, Turner SJ, Davenport MP.
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18691-6. Epub 2006 Nov 27.


Antimicrobial Agents and Chemotherapy
Engineered vaginal lactobacillus strain for mucosal delivery of the human immunodeficiency virus inhibitor cyanovirin-N.
Liu X, Lagenaur LA, Simpson DA, Essenmacher KP, Frazier-Parker CL, Liu Y, Tsai D, Rao SS, Hamer DH, Parks TP, Lee PP, Xu Q.
Antimicrob Agents Chemother. 2006 Oct;50(10):3250-9.

The Journal of Immunology
Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype.
Leslie A, Price DA, Mkhize P, Bishop K, Rathod A, Day C, Crawford H, Honeyborne I, Asher TE, Luzzi G, Edwards A, Rosseau CM, Mullins JI, Tudor-Williams G, Novelli V, Brander C, Douek DC, Kiepiela P, Walker BD, Goulder PJ.
J Immunol. 2006 Oct 1;177(7):4699-708.

Proceedings of the National Academy of Sciences of the United States of America
Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination.
Kong WP, Hood C, Yang ZY, Wei CJ, Xu L, Garcia-Sastre A, Tumpey TM, Nabel GJ.
Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15987-91. Epub 2006 Oct 16.


Clinical and Vaccine Immunology
A DNA Vaccine for Ebola Virus is Safe and Immunogenic in a Phase I Clinical Trial.
Martin JE, Sullivan NJ, Enama ME, Gordon IJ, Roederer M, Koup RA, Bailer RT, Chakrabarti BK, Bailey MA, Gomez PL, Andrews CA, Moodie Z, Gu L, Stein JA, Nabel GJ, Graham BS.
Clin Vaccine Immunol. 2006 Sep 20; [Epub ahead of print]

The Journal of Experimental Medicine
PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection.
Petrovas C, Casazza JP, Brenchley JM, Price DA, Gostick E, Adams WC, Precopio ML, Schacker T, Roederer M, Douek DC, Koup RA.
J Exp Med. 2006 Sep 5; [Epub ahead of print]


Journal of Virology
Virus-specific cellular immune correlates of survival in vaccinated monkeys after simian immunodeficiency virus challenge.
Sun Y, Schmitz JE, Buzby AP, Barker BR, Rao SS, Xu L, Yang ZY, Mascola JR, Nabel GJ, Letvin NL.
J Virol. 2006 Aug 30; [Epub ahead of print]

The Journal of Immunology
Subunit recombinant vaccine protects against monkeypox.
Heraud JM, Edghill-Smith Y, Ayala V, Kalisz I, Parrino J, Kalyanaraman VS, Manischewitz J, King LR, Hryniewicz A, Trindade CJ, Hassett M, Tsai WP, Venzon D, Nalca A, Vaccari M, Silvera P, Bray M, Graham BS, Golding H, Hooper JW, Franchini G.
J Immunol. 2006 Aug 15;177(4):2552-64.

The Journal of Immunology
IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection.
Foulds KE, Rotte MJ, Seder RA.
J Immunol. 2006 Aug 15;177(4):2565-74.


Journal of Virological Methods
Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor.
Yu JS, Liao HX, Gerdon AE, Huffman B, Scearce RM, McAdams M, Alam SM, Popernack PM, Sullivan NJ, Wright D, Cliffel DE, Nabel GJ, Haynes BF.
J Virol Methods. 2006 Jul 18; [Epub ahead of print]

Journal of Virology
Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen.
Weaver EA, Lu Z, Camacho ZT, Moukdar F, Liao HX, Ma BJ, Muldoon M, Theiler J, Nabel GJ, Letvin NL, Korber BT, Hahn BH, Haynes BF, Gao F.
J Virol. 2006 Jul;80(14):6745-56.

Nature Medicine
Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry.
Chattopadhyay PK, Price DA, Harper TF, Betts MR, Yu J, Gostick E, Perfetto SP, Goepfert P, Koup RA, De Rosa SC, Bruchez MP, Roederer M.
Nat Med. 2006 Jul 23; [Epub ahead of print]

Journal of Immunological Methods
Amine reactive dyes: An effective tool to discriminate live and dead cells in polychromatic flow cytometry.
Perfetto SP, Chattopadhyay PK, Lamoreaux L, Nguyen R, Ambrozak D, Koup RA, Roederer M.
J Immunol Methods. 2006 Jun 30;313(1-2):199-208. Epub 2006 May 19.

HIV-1 Envgp140 trimers elicit neutralizing antibodies without efficient induction of conformational antibodies.
Bower JF, Li Y, Wyatt R, Ross TM.
Vaccine. 2006 Jun 29;24(26):5442-51. Epub 2006 Apr 3

Journal of Virology
Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo.
Brenchley JM, Ruff LE, Casazza JP, Koup RA, Price DA, Douek DC.
J Virol. 2006 Jul;80(14):6801-9.


Microbes and Infection
Human memory T cell responses to SARS-CoV E protein.
Peng H, Yang LT, Li J, Lu ZQ, Wang LY, Koup RA, Bailer RT, Wu CY.
Microbes Infect. 2006 Jun 30; [Epub ahead of print]

Cross-clade recognition and neutralization by the V3 region from clade C human immunodeficiency virus-1 envelope.
Wu L, Yang ZY, Xu L, Welcher B, Winfrey S, Shao Y, Mascola JR, Nabel GJ.
Vaccine . 2006 Jun 5;24(23):4995-5002. Epub 2006 Apr 18.

Experimental Hematology
Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: Implications for graft engineering.
Scheinberg P, Price DA, Ambrozak DR, Barrett AJ, Douek DC.
Exp Hematol . 2006 Jun;34(6):788-95.

Journal of Immunology
Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection.
Duvall MG, Jaye A, Dong T, Brenchley JM, Alabi AS, Jeffries DJ, van der Sande M, Togun TO, McConkey SJ, Douek DC, McMichael AJ, Whittle HC, Koup RA, Rowland-Jones SL.
J Immunol . 2006 Jun 1;176(11):6973-81.

Journal of Immunology
Degeneracy and Repertoire of the Human HIV-1 Gag p1777-85 CTL Response.
Kan-Mitchell J, Bajcz M, Schaubert KL, Price DA, Brenchley JM, Asher TE, Douek DC, Ng HL, Yang OO, Rinaldo CR Jr, Benito JM, Bisikirska B, Hegde R, Marincola FM, Boggiano C, Wilson D, Abrams J, Blondelle SE, Wilson DB.
J Immunol. 2006 Jun 1;176(11):6690-701

Current Opinion in HIV/AIDS
HIV vaccines: can mucosal CD4 T cells be protected?
Joseph J. Mattapallil* and Mario Roederer
Current Opinion in HIV/AIDS, 7 (1): 272-276.

Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys.
Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, Xu L, Yang ZY, Chakrabarti B, Rao SS, Schmitz JE, Montefiori DC, Barker BR, Bookstein FL, Nabel GJ.
Science . 2006 Jun 9;312(5779):1530-3.

Clinical Immunology
Long-lived effector/central memory T-cell responses to severe acute respiratory syndrome coronavirus (SARS-CoV) S antigen in recovered SARS patients.
Yang LT, Peng H, Zhu ZL, Li G, Huang ZT, Zhao ZX, Koup RA, Bailer RT, Wu CY.
Clin Immunol . 2006 Jun 15; [Epub ahead of print]

AIDS Res Hum Retroviruses
Longitudinal Assessment of de Novo T Cell Production in Relation to HIV-Associated T Cell Homeostasis Failure.
Chattopadhyay PK, Douek DC, Gange SJ, Chadwick KR, Hellerstein M, Margolick JB.
AIDS Res Hum Retroviruses . 2006 Jun;22(6):501-7.

Analytical Biochemistry
A biosensor-based approach toward purification and crystallization of G protein-coupled receptors.
Navratilova I, Pancera M, Wyatt RT, Myszka DG.
Anal Biochem. 2006 Jun 15;353(2):278-83. Epub 2006 Apr 18.


Molecular and Cellular Biology
Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis.
Ganesh L, Yoshimoto T, Moorthy NC, Akahata W, Boehm M, Nabel EG, Nabel GJ.
Mol Cell Biol. 2006 May;26(10):3864-74.

Journal of Experimental Medicine
Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge.
Mattapallil JJ, Douek DC, Buckler-White A, Montefiori D, Letvin NL, Nabel GJ, Roederer M.
J Exp Med. 2006 May 30; [Epub ahead of print]

PLoS Medicine
Immune Protection of Nonhuman Primates against Ebola Virus with Single Low-Dose Adenovirus Vectors Encoding Modified GPs.
Sullivan NJ, Geisbert TW, Geisbert JB, Shedlock DJ, Xu L, Lamoreaux L, Custers JH, Popernack PM, Yang ZY, Pau MG, Roederer M, Koup RA, Goudsmit J, Jahrling PB, Nabel GJ.
PLoS Med. 2006 May 16;3(6):e177 [Epub ahead of print]

Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients.
Peng H, Yang LT, Wang LY, Li J, Huang J, Lu ZQ, Koup RA, Bailer RT, Wu CY.
Virology. 2006 May 9; [Epub ahead of print]

Vaccines: engineering immune evasion.
Mascola JR.
Nature. 2006 May 11;441(7090):161. No abstract available.

Journal of Immunology
Preservation of Functional Virus-Specific Memory CD8+ T Lymphocytes in Vaccinated, Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys.
Acierno PM, Schmitz JE, Gorgone DA, Sun Y, Santra S, Seaman MS, Newberg MH, Mascola JR, Nabel GJ, Panicali D, Letvin NL.
J Immunol. 2006 May 1;176(9):5338-45.

Journal of Immunology
Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus.
Chi B, Dickensheets HL, Spann KM, Alston MA, Luongo C, Dumoutier L, Huang J, Renauld JC, Kotenko SV, Roederer M, Beeler JA, Donnelly RP, Collins PL, Rabin RL.
J Virol. 2006 May;80(10):5032-40.


Journal of Experimental Medicine
Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates.
Wille-Reece U, Flynn BJ, Lore K, Koup RA, Miles AP, Saul A, Kedl RM, Mattapallil JJ, Weiss WR, Roederer M, Seder RA.
J Exp Med. 2006 Apr 24; [Epub ahead of print].

Polyvalent HIV-1 Env vaccine formulations delivered by the DNA priming plus protein boosting approach are effective in generating neutralizing antibodies against primary human immunodeficiency virus type 1 isolates from subtypes A, B, C, D and E.
Wang S, Pal R, Mascola JR, Chou TH, Mboudjeka I, Shen S, Liu Q, Whitney S, Keen T, Nair BC, Kalyanaraman VS, Markham P, Lu S.
Virology. 2006 Apr 6; [Epub ahead of print]

A new "Logicle" display method avoids deceptive effects of logarithmic scaling for low signals and compensated data.
Parks DR, Roederer M, Moore WA.
Cytometry A. 2006 Apr 7; [Epub ahead of print]

HIV-1 Env(gp140) trimers elicit neutralizing antibodies without efficient induction of conformational antibodies.
Bower JF, Li Y, Wyatt R, Ross TM.
Vaccine. 2006 Apr 3; [Epub ahead of print]


Toxicological Sciences
Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts.
Sheets RL, Stein J, Manetz TS, Duffy C, Nason M, Andrews C, Kong WP, Nabel GJ, Gomez PL.
Toxicol Sci. 2006 Jun;91(2):610-619. Epub 2006 Mar 28.

Toxicological Sciences
Toxicological Safety Evaluation of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar Despite Differing Plasmid Backbones or Gene-Inserts.
Sheets RL, Stein J, Manetz TS, Andrews C, Bailer R, Rathmann J, Gomez PL.
Toxicol Sci. 2006 Jun;91(2):620-630. Epub 2006 Mar 28.

Journal of Virology
Human immunodeficiency virus (HIV) vaccine trials: a novel assay for differential diagnosis of HIV infections in the face of vaccine-generated antibodies.
Khurana S, Needham J, Mathieson B, Rodriguez-Chavez IR, Catanzaro AT, Bailer RT, Kim J, Polonis V, Cooper DA, Guerin J, Peterson ML, Gurwith M, Nguyen N, Graham BS, Golding H.
J Virol. 2006 Mar;80(5):2092-9.

Nature Immunology
HIV disease: fallout from a mucosal catastrophe?
Brenchley JM, Price DA, Douek DC.
Nat Immunol. 2006 Mar;7(3):235-9.


Current HIV/AIDS reports
Current advances and challenges in HIV-1 vaccines.
Rodriguez-Chavez IR, Allen M, Hill EL, Sheets RL, Pensiero M, Bradac JA, D'Souza MP.
Curr HIV/AIDS Rep. 2006 Feb;3(1):39-47. Review.

The rational design of an AIDS vaccine.
Douek DC, Kwong PD, Nabel GJ.
Cell. 2006 Feb 24;124(4):677-81

Stem Cells
In vitro culture during retroviral transduction improves thymic repopulation and output after TBI and autologous PBPC transplantation in rhesus macaques.
Lore K, Seggewiss R, Guenaga FJ, Pittaluga S, Donahue RE, Krouse A, Metzger ME, Koup RA, Reilly C, Douek DC, Dunbar CE.
Stem Cells. 2006 Feb 23; [Epub ahead of print]

HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells.
Betts MR, Nason MC, West SM, De Rosa SC, Migueles SA, Abraham J, Lederman MM, Benito JM, Goepfert PA, Connors M, Roederer M, Koup RA.
Blood. 2006 Feb 7; [Epub ahead of print]

Journal of Virology
Characterization of antibody responses elicited by human immunodeficiency virus type 1 primary isolate trimeric and monomeric envelope glycoproteins in selected adjuvants.
Li Y, Svehla K, Mathy NL, Voss G, Mascola JR, Wyatt R.
J Virol. 2006 Feb;80(3):1414-26.

Immunization of rhesus macaques with a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine elicits protective antibody response against simian human immunodeficiency virus of R5 phenotype.
Pal R, Wang S, Kalyanaraman VS, Nair BC, Whitney S, Keen T, Hocker L, Hudacik L, Rose N, Mboudjeka I, Shen S, Wu-Chou TH, Montefiori D, Mascola J, Markham P, Lu S.
Virology. 2006 Feb 2; [Epub ahead of print]

Journal of Virology
Infectious molecular clones from a simian immunodeficiency virus-infected rapid-progressor (RP) macaque: evidence of differential selection of RP-specific envelope mutations in vitro and in vivo.
Kuwata T, Dehghani H, Brown CR, Plishka R, Buckler-White A, Igarashi T, Mattapallil J, Roederer M, Hirsch VM.
J Virol. 2006 Feb;80(3):1463-75.


Current Opinion in HIV/AIDS
Acute HIV infection: it takes more than guts!
Joseph Mattapallil* and Mario Roederer
Current Opinion in HIV/AIDS 2006, 1:10-15

Comparative evaluation of three different intramuscular delivery methods for DNA immunization in a nonhuman primate animal model.
Rao SS, Gomez P, Mascola JR, Dang V, Krivulka GR, Yu F, Lord CI, Shen L, Bailer R, Nabel GJ, Letvin NL.
Vaccine. Jan 16;24(3):367-73.

Public Library of Science Medicine
New approaches to vaccine adjuvants: inhibiting the inhibitor.
Graham BS.
PLoS Med. 2006 Jan;3(1):e57

Trends in Immunology
Renewing the T cell repertoire to arrest autoimmune aggression.
Muraro PA, Douek DC.
Trends Immunol. 2006 Jan 4

Journal of Pathology
Infection and disease: cause and cure.
Herrington CS, Douek DC.
J Pathol. 2006 Jan;208(2):131-3.

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Last Updated October 06, 2008