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Vaccine Research Center Journal Publications, 2010

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Proceedings of the National Academy of Sciences USA
Genetic immunization in the lung induces potent local and systemic immune responses.
Song K, Bolton DL, Wilson RL, Camp JV, Bao S, Mattapallil JJ, Herzenberg LA, Herzenberg LA, Andrews CA, Sadoff JC, Goudsmit J, Pau MG, Seder RA, Kozlowski PA, Nabel GJ, Roederer M, Rao SS.
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22213-8. Epub 2010 Dec 6.

Journal of Immunology
Persistent survival of prevalent clonotypes within an immunodominant HIV gag-specific CD8+ T cell response.
van Bockel DJ, Price DA, Munier ML, Venturi V, Asher TE, Ladell K, Greenaway HY, Zaunders J, Douek DC, Cooper DA, Davenport MP, Kelleher AD.
J Immunol. 2011 Jan 1;186(1):359-71. Epub 2010 Dec 6.

AIDS Research and Human Retroviruses
Early Short-term Anti-retroviral Therapy is Associated with a Reduced Prevalence of CD8+FoxP3+ T cells in SIV Infected Controller Rhesus Macaques.
George J, Brocca-Cofano E, Lybarger E, Louder M, Lafont B, Mascola J, Robert-Guroff M, Mattapallil JJ.
AIDS Res Hum Retroviruses. 2010 Dec 8. [Epub ahead of print]

Public Library of Science One
Equivalence of ELISpot Assays Demonstrated between Major HIV Network Laboratories.
Gill DK, Huang Y, Levine GL, Sambor A, Carter DK, Sato A, Kopycinski J, Hayes P, Hahn B, Birungi J, Tarragona-Fiol T, Wan H, Randles M, Cooper AR, Ssemaganda A, Clark L, Kaleebu P, Self SG, Koup R, Wood B, McElrath MJ, Cox JH, Hural J, Gilmour J.
PLoS One. 2010 Dec 14;5(12):e14330.

Nature Medicine
Induction of unnatural immunity: prospects for a broadly protective universal influenza vaccine.
Nabel GJ, Fauci AS.
Nat Med. 2010 Dec;16(12):1389-91.

AIDS Research and Human Retroviruses
HIV-1 Env Precursor Cleavage State Affects Recognition by Both Neutralizing and Non-neutralizing gp41 Antibodies.
Wyatt RT, Chakrabarti BK, Pancera M, Phogat S, O'Dell S, McKee KI, Guenaga JF, Robinson J, Mascola JR.
AIDS Res Hum Retroviruses. 2010 Dec 16. [Epub ahead of print]

Nature Reviews Immunology
The quest for a T cell-based immune correlate of protection against HIV: a story of trials and errors.
Koup RA, Graham BS, Douek DC.
Nat Rev Immunol. 2010 Jan;11(1):65-70. Epub 2010 Dec 17.

Journal of Virology
Crystal structure of human antibody 2909 reveals conserved features of quaternary-specific antibodies that potently neutralize HIV-1.
Changela A, Wu X, Yang Y, Zhang B, Zhu J, Nardone GA, O'Dell S, Pancera M, Gorny MK, Phogat S, Robinson JE, Stamatatos L, Zolla-Pazner S, Mascola JR, Kwong PD.
J Virol. 2010 Dec 29. [Epub ahead of print]


Journal of Infectious Diseases
Determinants of protection among HIV‐exposed seronegative persons: an overview.
Lederman MM, Alter G, Daskalakis DC, Rodriguez B, Sieg SF, Hardy G, Cho M, Anthony D, Harding C, Weinberg A, Silverman RH, Douek DC, Margolis L, Goldstein DB, Carrington M, Goedert JJ. J Infect Dis. 2010 Nov 1;202 Suppl 3:S333-8. Review.

Nature Immunology
A model for harmonizing flow cytometry in clinical trials.
Maecker HT, McCoy JP Jr; FOCIS Human Immunophenotyping Consortium, Amos M, Elliott J, Gaigalas A, Wang L, Aranda R, Banchereau J, Boshoff C, Braun J, Korin Y, Reed E, Cho J, Hafler D, Davis M, Fathman CG, Robinson W, Denny T, Weinhold K, Desai B, Diamond B, Gregersen P, DiMeglio P, Nestle F, Peakman M, Villnova F, Ferbas J, Field E, Kantor A, Kawabata T, Komocsar W, Lotze M, Nepom J, Ochs H, O'Lone R, Phippard D, Plevy S, Rich S, Roederer M, Rotrosen D, Yeh JH. Nat Immunol. 2010 Nov;11(11):975-8.

T cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy.
Sloand EM, Melenhorst JJ, Tucker ZC, Pfannes L, Brenchley JM, Yong A, Visconte V, Wu C, Gostick E, Scheinberg P, Olnes MJ, Douek DC, Price DA, Barrett AJ, Young NS. Blood. 2010 Nov 19. [Epub ahead of print]

Journal of Experimental Medicine
Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection.
Geldmacher C, Ngwenyama N, Schuetz A, Petrovas C, Reither K, Heeregrave EJ, Casazza JP, Ambrozak DR, Louder M, Ampofo W, Pollakis G, Hill B, Sanga E, Saathoff E, Maboko L, Roederer M, Paxton WA, Hoelscher M, Koup RA. J Exp Med. 2010 Nov 29. [Epub ahead of print]

Journal of Biological Chemistry
T cell receptor clonotype influences epitope hierarchy in the CD8+ T cell response to respiratory syncytial virus infection.
Billam P, Bonaparte KL, Liu J, Ruckwardt TJ, Chen M, Ryder AB, Wang R, Dash P, Thomas PG, Graham BS. J Biol Chem. 2010 Nov 30. [Epub ahead of print]


Journal of Virology
Characterization of human adenovirus 35 and derivation of complex vectors.
McVey D, Zuber M, Ettyreddy D, Reiter CD, Brough DE, Nabel GJ, Richter King C, Gall JG.
Virol J. 2010 Oct 19;7(1):276. [Epub ahead of print] 

BMC Microbiology
Universal and specific quantitative detection of botulinum neurotoxin genes.
Hill BJ, Skerry JC, Smith TJ, Arnon SS, Douek DC.
BMC Microbiol. 2010 Oct 20;10(1):267. [Epub ahead of print]

Convergent recombination shapes the clonotypic landscape of the naive T-cell repertoire.
Quigley MF, Greenaway HY, Venturi V, Lindsay R, Quinn KM, Seder RA, Douek DC, Davenport MP, Price DA.
Proc Natl Acad Sci U S A. 2010 Oct 25. [Epub ahead of print]

A replication defective recombinant Ad5 vaccine expressing Ebola virus GP is safe and immunogenic in healthy adults.
Ledgerwood JE, Costner P, Desai N, Holman L, Enama ME, Yamshchikov G, Mulangu S, Hu Z, Andrews CA, Sheets RA, Koup RA, Roederer M, Bailer R, Mascola JR, Pau MG, Sullivan NJ, Goudsmit J, Nabel GJ, Graham BS; The VRC 205 Study Team.
Vaccine. 2010 Oct 26. [Epub ahead of print]

Journal of Immunology
CCR2 Identifies a Stable Population of Human Effector Memory CD4+ T Cells Equipped for Rapid Recall Response.
Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM.
J Immunol. 2010 Oct 27. [Epub ahead of print]

PLoS One
Safety and Immunogenicity of a Replication-Defective Adenovirus Type 5 HIV Vaccine in Ad5-Seronegative Persons: A Randomized Clinical Trial (HVTN 054).
Peiperl L, Morgan C, Moodie Z, Li H, Russell N, Graham BS, Tomaras GD, De Rosa SC, McElrath MJ; the NIAID HIV Vaccine Trials Network.
PLoS One. 2010 Oct 27;5(10):e13579.

Heavy metal contaminants can eliminate quantum dot fluorescence.
Zarkowsky D, Lamoreaux L, Chattopadhyay P, Koup RA, Perfetto SP, Roederer M.
Cytometry A. 2010 Oct 28. [Epub ahead of print]

Vaccine adjuvants: putting innate immunity to work.
Coffman RL, Sher A, Seder RA.
Immunity. 2010 Oct 29;33(4):492-503.


OMIPs--Orchestrating multiplexity in polychromatic science.
Roederer M, Tárnok A.
Cytometry A. 2010 Sep;77(9):811-2.

OMIP-002: Phenotypic analysis of specific human CD8+ T-cells using peptide-MHC class I multimers for any of four epitopes.
Chattopadhyay PK, Roederer M, Price DA.
Cytometry A. 2010 Sep;77(9):821-2.

OMIP-001: Quality and phenotype of Ag-responsive human T-cells.
Mahnke YD, Roederer M.
Cytometry A. 2010 Sep;77(9):819-20.

Publication of optimized multicolor immunofluorescence panels.
Mahnke Y, Chattopadhyay P, Roederer M.
Cytometry A. 2010 Sep;77(9):814-8.

Journal of Immunology
Responses against a subdominant CD8+ T cell epitope protect against immunopathology caused by a dominant epitope.
Ruckwardt TJ, Luongo C, Malloy AM, Liu J, Chen M, Collins PL, Graham BS.
J Immunol. 2010 Oct 15;185(8):4673-80. Epub 2010 Sep 10.

Journal of Virology
Reduction of immune activation with chloroquine therapy during chronic HIV infection.
Murray SM, Down CM, Boulware DR, Stauffer WM, Cavert WP, Schacker TW, Brenchley JM, Douek DC.
J Virol. 2010 Nov;84(22):12082-6. Epub 2010 Sep 15.

PLoS One
Safety and immunogenicity study of Multiclade HIV-1 adenoviral vector vaccine alone or as boost following a multiclade HIV-1 DNA vaccine in Africa.
Jaoko W, Karita E, Kayitenkore K, Omosa-Manyonyi G, Allen S, Than S, Adams EM, Graham BS, Koup RA, Bailer RT, Smith C, Dally L, Farah B, Anzala O, Muvunyi CM, Bizimana J, Tarragona-Fiol T, Bergin PJ, Hayes P, Ho M, Loughran K, Komaroff W, Stevens G, Thomson H, Boaz MJ, Cox JH, Schmidt C, Gilmour J, Nabel GJ, Fast P, Bwayo J.
PLoS One. 2010 Sep 21;5(9):e12873.

Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates.
Tewari K, Flynn BJ, Boscardin SB, Kastenmueller K, Salazar AM, Anderson CA, Soundarapandian V, Ahumada A, Keler T, Hoffman SL, Nussenzweig MC, Steinman RM, Seder RA.
Vaccine. 2010 Oct 21;28(45):7256-66. Epub 2010 Sep 21.

Proceedings of National Academy of Sciences
Elicitation of structure-specific antibodies by epitope scaffolds.
Ofek G, Guenaga FJ, Schief WR, Skinner J, Baker D, Wyatt R, Kwong PD.
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17880-7. Epub 2010 Sep 27.

Journal of Virology
Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F.
McLellan JS, Chen M, Chang JS, Yang Y, Kim A, Graham BS, Kwong PD.
J Virol. 2010 Dec;84(23):12236-44. Epub 2010 Sep 29.


Journal of Experimental Medicine
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates.
Sundling C, Forsell MN, O'Dell S, Feng Y, Chakrabarti B, Rao SS, Loré K, Mascola JR, Wyatt RT, Douagi I, Karlsson Hedestam GB.
J Exp Med. 2010 Aug 30;207(9):2003-17. Epub 2010 Aug 2. Erratum in: J Exp Med. 2010 Sep 27;207(10):2283.

Journal of Virology
Epitope-specific regulatory CD4 T cells reduce virus-induced illness while preserving CD8 T-cell effector function at the site of infection. Liu J, Ruckwardt TJ, Chen M, Nicewonger JD, Johnson TR, Graham BS.
J Virol. 2010 Oct;84(20):10501-9. Epub 2010 Aug 4.

PLoS One
Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity.
Graham BS, McElrath MJ, Keefer MC, Rybczyk K, Berger D, Weinhold KJ, Ottinger J, Ferarri G, Montefiori DC, Stablein D, Smith C, Ginsberg R, Eldridge J, Duerr A, Fast P, Haynes BF; AIDS Vaccine Evaluation Group.
PLoS One. 2010 Aug 10;5(8):e11995.

Journal of Infectious Diseases
Intracellular Casp8p41 content is inversely associated with CD4 T cell count.
Cummins NW, Jiang W, McGinty J, Bren GD, Bosch RJ, Landay A, Deeks SG, Martin JN, Douek D, Lederman MM, Brenchley J, Badley AD.
J Infect Dis. 2010 Aug 15;202(3):386-91.

Journal of Immunological Methods
A flow cytometry-based assay to assess RSV-specific neutralizing antibody is reproducible, efficient and accurate.
Chen M, Chang JS, Nason M, Rangel D, Gall JG, Graham BS, Ledgerwood JE.
J Immunol Methods. 2010 Oct 31;362(1-2):180-4. Epub 2010 Aug 19.

PLoS Pathogens
Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections.
Estes JD, Harris LD, Klatt NR, Tabb B, Pittaluga S, Paiardini M, Barclay GR, Smedley J, Pung R, Oliveira KM, Hirsch VM, Silvestri G, Douek DC, Miller CJ, Haase AT, Lifson J, Brenchley JM.
PLoS Pathog. 2010 Aug 19;6(8). pii: e1001052.

Journal of Molecular Biology
Expression-system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity.
Kong L, Sheppard NC, Stewart-Jones GB, Robson CL, Chen H, Xu X, Krashias G, Bonomelli C, Scanlan CN, Kwong PD, Jeffs SA, Jones IM, Sattentau QJ.
J Mol Biol. 2010 Oct 15;403(1):131-47. Epub 2010 Aug 25.

Hypomorphic Rag mutations can cause destructive midline granulomatous disease.
De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, Niemela JE, Fontana-Penn M, Sinal SH, Malech HL.
Blood. 2010 Aug 26;116(8):1263-71. Epub 2010 May 20.

Proceedings of National Academy of Sciences
Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo.
Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, Kinkela TL, Blumberg S, Thomassen HA, Pike BL, Fair JN, Wolfe ND, Shongo RL, Graham BS, Formenty P, Okitolonda E, Hensley LE, Meyer H, Wright LL, Muyembe JJ.
Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16262-7. Epub 2010 Aug 30.


Current Protocols in Cytometry
Amine-reactive dyes for dead cell discrimination in fixed samples.
Perfetto SP, Chattopadhyay PK, Lamoreaux L, Nguyen R, Ambrozak D, Koup RA, Roederer M.
Curr Protoc Cytom. 2010 Jul;Chapter 9:Unit 9.34.

Data analysis in flow cytometry: the future just started.
Lugli E, Roederer M, Cossarizza A.
Cytometry A. 2010 Jul;77(7):705-13.

Good cell, bad cell: flow cytometry reveals T-cell subsets important in HIV disease.
Chattopadhyay PK, Roederer M.
Cytometry A. 2010 Jul;77(7):614-22.

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
The use of quantum dot nanocrystals in multicolor flow cytometry.
Chattopadhyay PK, Perfetto SP, Yu J, Roederer M.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Jul;2(4):334-48.

Journal of Immunology
CD8+ T cell responses following replication-defective adenovirus serotype 5 immunization are dependent on CD11c+ dendritic cells but show redundancy in their requirement of TLR and nucleotide-binding oligomerization domain-like receptor signaling.
Lindsay RW, Darrah PA, Quinn KM, Wille-Reece U, Mattei LM, Iwasaki A, Kasturi SP, Pulendran B, Gall JG, Spies AG, Seder RA.
J Immunol. 2010 Aug 1;185(3):1513-21. Epub 2010 Jul 7.

Journal of Virology
Immunization with wild-type or CD4 binding-defective HIV-1 Env trimers reduces viremia equivalently following heterologous SHIV challenge.
Sundling C, O'Dell S, Douagi I, Forsell MN, Mörner A, Loré K, Mascola JR, Wyatt RT, Karlsson Hedestam GB.
J Virol. 2010 Jul 7. [Epub ahead of print]

Journal of Virology
Reconstitution of CD4 T cells in BAL after Initiation of Highly Active Antiretroviral Therapy
Knox KS, Vinton C, Hage CA, Kohli LM, Twigg HL 3rd, Klatt NR, Zwickl B, Waltz J, Goldman M, Douek DC, Brenchley JM.
J Virol. 2010 Jul 7. [Epub ahead of print]

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1.
Wu X, Yang ZY, Li Y, Hogerkorp CM, Schief WR, Seaman MS, Zhou T, Schmidt SD, Wu L, Xu L, Longo NS, McKee K, O'Dell S, Louder MK, Wycuff DL, Feng Y, Nason M, Doria-Rose N, Connors M, Kwong PD, Roederer M, Wyatt RT, Nabel GJ, Mascola JR.
Science. 2010 Aug 13;329(5993):856-61. Epub 2010 Jul 8.

Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01.
Zhou T, Georgiev I, Wu X, Yang ZY, Dai K, Finzi A, Kwon YD, Scheid JF, Shi W, Xu L, Yang Y, Zhu J, Nussenzweig MC, Sodroski J, Shapiro L, Nabel GJ, Mascola JR, Kwong PD.
Science. 2010 Aug 13;329(5993):811-7. Epub 2010 Jul 8.

Transient and persistent effects of IL15 on lymphocyte homeostasis in nonhuman primates.
Lugli E, Goldman CK, Perera LP, Smedley J, Pung R, Yovandich JL, Creekmore SP, Waldmann TA, Roederer M.
Blood. 2010 Jul 14. [Epub ahead of print]

Induction of broadly neutralizing H1N1 influenza antibodies by vaccination.
Wei CJ, Boyington JC, McTamney PM, Kong WP, Pearce MB, Xu L, Andersen H, Rao S, Tumpey TM, Yang ZY, Nabel GJ.
Science. 2010 Aug 27;329(5995):1060-4. Epub 2010 Jul 15.

Journal of Virology
Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange.
Kong L, Huang CC, Coales SJ, Molnar KS, Skinner J, Hamuro Y, Kwong PD.
J Virol. 2010 Jul 21. [Epub ahead of print]

Journal of Virology
Vector Choice Determines Immunogenicity and Potency of Genetic Vaccines Against Angola Marburgvirus in Nonhuman Primates.
Geisbert T, Bailey M, Geisbert J, Asiedu C, Roederer M, Grazia-Pau M, Custers J, Jahrling P, Goudsmit J, Koup R, Sullivan NJ.
J Virol. 2010 Jul 21. [Epub ahead of print]

Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.
Antonelli LR, Mahnke Y, Hodge JN, Porter BO, Barber DL, Dersimonian R, Greenwald JH, Roby G, Mican J, Sher A, Roederer M, Sereti I.
Blood. 2010 Jul 26. [Epub ahead of print]

Recombinant vector-induced HIV/SIV-specific CD4(+) T lymphocyte responses in rhesus monkeys.
Sun Y, Santra S, Buzby AP, Mascola JR, Nabel GJ, Letvin NL.
Virology. 2010 Jul 26. [Epub ahead of print]


Journal of Experimental Medicine
IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform.
Darrah PA, Hegde ST, Patel DT, Lindsay RW, Chen L, Roederer M, Seder RA.
J Exp Med. 2010 Jul 5;207(7):1421-33. Epub 2010 Jun 7.

Journal of Medicinal Chemistry
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231).
O'Neill DJ, Adedoyin A, Alfinito PD, Bray JA, Cosmi S, Deecher DC, Fensome A, Harrison J, Leventhal L, Mann C, McComas CC, Sullivan NR, Spangler TB, Uveges AJ, Trybulski EJ, Whiteside GT, Zhang P.
J Med Chem. 2010 Jun 10;53(11):4511-21.

Journal of Virology
Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1.
Pancera M, McLellan JS, Wu X, Zhu J, Changela A, Schmidt SD, Yang Y, Zhou T, Phogat S, Mascola JR, Kwong PD.
J Virol. 2010 Aug;84(16):8098-110. Epub 2010 Jun 10.

Mucosal Immunology
Mucosal delivery of human papillomavirus pseudovirus-encapsidated plasmids improves the potency of DNA vaccination.
Graham BS, Kines RC, Corbett KS, Nicewonger J, Johnson TR, Chen M, Lavigne D, Roberts JN, Cuburu N, Schiller JT, Buck CB.
Mucosal Immunol. 2010 Jun 16. [Epub ahead of print]

Nonprogressive and progressive primate immunodeficiency lentivirus infections.
Brenchley JM, Silvestri G, Douek DC.
Immunity. 2010 Jun 25;32(6):737-42.


PLoS One
Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute/early HIV-1 infection.
Rosenberg ES, Graham BS, Chan ES, Bosch RJ, Stocker V, Maenza J, Markowitz M, Little S, Sax PE, Collier AC, Nabel G, Saindon S, Flynn T, Kuritzkes D, Barouch DH; AIDS Clinical Trials Group A5187 Team.
PLoS One. 2010 May 10;5(5):e10555.

Journal of Virological Methods
Conformational characterization of aberrant disulfide-linked HIV-1 gp120 dimers secreted from overexpressing cells.
Finzi A, Pacheco B, Zeng X, Kwon YD, Kwong PD, Sodroski J.
J Virol Methods. 2010 May 13. [Epub ahead of print]

European Journal of Immunology
Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.
Rosario M, Bridgeman A, Quakkelaar ED, Quigley MF, Hill BJ, Knudsen ML, Ammendola V, Ljungberg K, Borthwick N, Im EJ, McMichael AJ, Drijfhout JW, Greenaway HY, Venturi V, Douek DC, Colloca S, Liljeström P, Nicosia A, Price DA, Melief CJ, Hanke T.
Eur J Immunol. 2010 May 14. [Epub ahead of print]

Science Translational Medicine
Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.
Favre D, Mold J, Hunt PW, Kanwar B, Loke P, Seu L, Barbour JD, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek DC, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM.
Sci Transl Med. 2010 May 19;2(32):32ra36.

Journal of Virology
Down-Regulation of Robust Acute Type I IFN Responses Distinguishes Non-Pathogenic SIV Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques.
Harris LD, Tabb B, Sodora DL, Paiardini M, Klatt NR, Douek DC, Silvestri G, Muller-Trutwin M, Vasile-Pandrea I, Apetrei C, Hirsch V, Lifson J, Brenchley JM, Estes JD.
J Virol. 2010 May 19. [Epub ahead of print]

Hypomorphic Rag mutations can cause destructive midline granulomatous disease.
De Ravin SS, Cowen EW, Zarember KA, Whiting-Theobald NL, Kuhns DB, Sandler NG, Douek DC, Pittaluga S, Poliani PL, Lee YN, Notarangelo LD, Wang L, Alt FW, Kang EM, Milner JD, Niemela JE, Fontana-Penn M, Sinal SH, Malech HL.
Blood. 2010 May 20. [Epub ahead of print]

PLoS Pathogens
Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species.
Hensley LE, Mulangu S, Asiedu C, Johnson J, Honko AN, Stanley D, Fabozzi G, Nichol ST, Ksiazek TG, Rollin PE, Wahl-Jensen V, Bailey M, Jahrling PB, Roederer M, Koup RA, Sullivan NJ.
PLoS Pathog. 2010 May 20;6(5):e1000904.


Journal of Immunology
A steady state of CD4(+) T cell memory maturation and activation is established during primary subtype C HIV-1 infection.
Maenetje P, Riou C, Casazza JP, Ambrozak D, Hill B, Gray G, Koup RA, de Bruyn G, Gray CM.
J Immunol. 2010 May 1;184(9):4926-35. Epub 2010 Apr 2.

Journal of Virology
Novel recombinant Mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus Ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaques.
Rosario M, Hopkins R, Fulkerson J, Borthwick N, Quigley MF, Joseph J, Douek DC, Greenaway HY, Venturi V, Gostick E, Price DA, Both GW, Sadoff JC, Hanke T.
J Virol. 2010 Jun;84(12):5898-908. Epub 2010 Apr 7.

European Journal of Immunology
Generation of robust CD8(+) T-cell responses against subdominant epitopes in conserved regions of HIV-1 by repertoire mining with mimotopes.
Schaubert KL, Price DA, Salkowitz JR, Sewell AK, Sidney J, Asher TE, Blondelle SE, Adams S, Marincola FM, Joseph A, Sette A, Douek DC, Ayyavoo V, Storkus W, Leung MY, Ng HL, Yang OO, Goldstein H, Wilson DB, Kan-Mitchell J.
Eur J Immunol. 2010 Apr 28. [Epub ahead of print]


Journal of Virology
Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination.
Freel SA, Lamoreaux L, Chattopadhyay PK, Saunders K, Zarkowsky D, Overman RG, Ochsenbauer C, Edmonds TG, Kappes JC, Cunningham CK, Denny TN, Weinhold KJ, Ferrari G, Haynes BF, Koup RA, Graham BS, Roederer M, Tomaras GD.
J Virol. 2010 May;84(10):4998-5006. Epub 2010 Mar 3.

Nature Medicine
Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection.
Said EA, Dupuy FP, Trautmann L, Zhang Y, Shi Y, El-Far M, Hill BJ, Noto A, Ancuta P, Peretz Y, Fonseca SG, Van Grevenynghe J, Boulassel MR, Bruneau J, Shoukry NH, Routy JP, Douek DC, Haddad EK, Sekaly RP.
Nat Med. 2010 Apr;16(4):452-9. Epub 2010 Mar 7.

Molecular Cell
Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions.
Finzi A, Xiang SH, Pacheco B, Wang L, Haight J, Kassa A, Danek B, Pancera M, Kwong PD, Sodroski J.
Mol Cell. 2010 Mar 12;37(5):656-67.

Antibody-mediated neutralization of Ebola virus can occur by two distinct mechanisms.
Shedlock DJ, Bailey MA, Popernack PM, Cunningham JM, Burton DR, Sullivan NJ.
Virology. 2010 Jun 5;401(2):228-35. Epub 2010 Mar 20.

PLoS One
Comparative efficacy of hemagglutinin, nucleoprotein, and matrix 2 protein gene-based vaccination against H5N1 influenza in mouse and ferret.
Rao SS, Kong WP, Wei CJ, Van Hoeven N, Gorres JP, Nason M, Andersen H, Tumpey TM, Nabel GJ.
PLoS One. 2010 Mar 23;5(3):e9812.

Science Translational Medicine
Cross-neutralization of 1918 and 2009 influenza viruses: role of glycans in viral evolution and vaccine design.
Wei CJ, Boyington JC, Dai K, Houser KV, Pearce MB, Kong WP, Yang ZY, Tumpey TM, Nabel GJ.
Sci Transl Med. 2010 Mar 24;2(24):24ra21.

Annual Review of Immunology
The role of antibodies in HIV vaccines.
Mascola JR, Montefiori DC.
Annu Rev Immunol. 2010 Mar;28:413-44. Review.


Nature Medicine
Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8(+) T cell immunity.
Flatz L, Hegazy AN, Bergthaler A, Verschoor A, Claus C, Fernandez M, Gattinoni L, Johnson S, Kreppel F, Kochanek S, Broek MV, Radbruch A, Lévy F, Lambert PH, Siegrist CA, Restifo NP, Löhning M, Ochsenbein AF, Nabel GJ, Pinschewer DD.
Nat Med. 2010 Feb 7.

Priming immunization with DNA augments immunogenicity of recombinant adenoviral vectors for both HIV-1 specific antibody and T-cell responses.
Koup RA, Roederer M, Lamoreaux L, Fischer J, Novik L, Nason MC, Larkin BD, Enama ME, Ledgerwood JE, Bailer RT, Mascola JR, Nabel GJ, Graham BS; VRC 009 Study Team; VRC 010 Study Team.
PLoS One. 2010 Feb 2;5(2):e9015.

Nature Structural Molecular Biology
Structural basis of respiratory syncytial virus neutralization by motavizumab.
McLellan JS, Chen M, Kim A, Yang Y, Graham BS, Kwong PD.
Nat Struct Mol Biol. 2010 Feb;17(2):248-50.

Journal of Infectious Diseases
A phase 1/2 study of a multiclade HIV-1 DNA plasmid prime and recombinant adenovirus serotype 5 boost vaccine in HIV-Uninfected East Africans (RV 172).
Kibuuka H, Kimutai R, Maboko L, Sawe F, Schunk MS, Kroidl A, Shaffer D, Eller LA, Kibaya R, Eller MA, Schindler KB, Schuetz A, Millard M, Kroll J, Dally L, Hoelscher M, Bailer R, Cox JH, Marovich M, Birx DL, Graham BS, Michael NL, de Souza MS, Robb ML.
J Infect Dis. 2010 Feb 15;201(4):600-7.


Journal of Infectious Diseases
Immunologic and Virologic Events in Early HIV Infection Predict Subsequent Rate of Progression.
Ganesan A, Chattopadhyay PK, Brodie TM, Qin J, Gu W, Mascola JR, Michael NL, Follmann DA, Roederer M.
J Infect Dis. 2010 Jan 15;201(2):272-284.

Cytometry A
Data File Standard for Flow Cytometry, version FCS 3.1.
Spidlen J, Moore W, Parks D, Goldberg M, Bray C, Bierre P, Gorombey P, Hyun B, Hubbard M, Lange S, Lefebvre R, Leif R, Novo D, Ostruszka L, Treister A, Wood J, Murphy RF, Roederer M, Sudar D, Zigon R, Brinkman RR.
Cytometry A. 2010 Jan;77(1):97-100.

Journal of Virology
Differential specificity and immunogenicity of adenovirus type 5 neutralizing antibodies elicited by natural infection or immunization.
Cheng C, Gall JG, Nason M, King CR, Koup RA, Roederer M, McElrath MJ, Morgan CA, Churchyard G, Baden LR, Duerr AC, Keefer MC, Graham BS, Nabel GJ.
J Virol. 2010 Jan;84(1):630-8.

Nature Medicine
A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection.
Akahata W, Yang ZY, Andersen H, Sun S, Holdaway HA, Kong WP, Lewis MG, Higgs S, Rossmann MG, Rao S, Nabel GJ.
Nat Med. 2010 Jan 28.

Wiley Interdisciplinary Review
The use of quantum dot nanocrystals in multicolor flow cytometry.
Chattopadhyay PK, Perfetto SP, Yu J, Roederer M.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Jan 25.

Journal of Virology
A V3 Loop-Dependent gp120 Element Disrupted by CD4 Binding Stabilizes the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Trimer.
Xiang SH, Finzi A, Pacheco B, Alexander K, Yuan W, Rizzuto C, Huang CC, Kwong PD, Sodroski J. J Virol. 2010 Jan 20.

Proceedings of National Academy of Sciences
Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Pancera M, Majeed S, Ban YE, Chen L, Huang CC, Kong L, Kwon YD, Stuckey J, Zhou T, Robinson JE, Schief WR, Sodroski J, Wyatt R, Kwong PD.
Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1166-71.

Journal of Virology
Biochemical and structural characterization of cathepsin L-processed ebola virus glycoprotein: implications for viral entry and immunogenicity.
Hood CL, Abraham J, Boyington JC, Leung K, Kwong PD, Nabel GJ.
J Virol. 2010 Mar;84(6):2972-82. Epub 2010 Jan 6.

Journal of Infectious Disease
Immunologic and virologic events in early HIV infection predict subsequent rate of progression.
Ganesan A, Chattopadhyay PK, Brodie TM, Qin J, Gu W, Mascola JR, Michael NL, Follmann DA, Roederer M; Infectious Disease Clinical Research Program HIV Working Group.
J Infect Dis. 2010 Jan 15;201(2):272-84.

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Last Updated February 02, 2011

Last Reviewed February 02, 2011