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Journal Publications, 2011

The NIH Library provides information about online journal access.

December

Haematologica
Cytopenia and leukocyte recovery shape cytokine fluctuations after myeloablative allogeneic hematopoietic stem cell transplantation.
Melenhorst JJ, Tian X, Xu D, Sandler NG, Scheinberg P, Biancotto A, Scheinberg P, McCoy JP, Hensel NF, McIver Z, Douek DC, Barrett AJ.
Haematologica. 2011 Dec 1. [Epub ahead of print]

Public Library of Science Pathogens
Neonatal CD8 T-cell Hierarchy Is Distinct from Adults and Is Influenced by Intrinsic T cell Properties in Respiratory Syncytial Virus Infected Mice.
Ruckwardt TJ, Malloy AM, Gostick E, Price DA, Dash P, McClaren JL, Thomas PG, Graham BS.
PLoS Pathog. 2011 Dec;7(12):e1002377. Epub 2011 Dec 1.

Journal of Immonology
Targeting the Vaginal Mucosa with Human Papillomavirus Pseudovirion Vaccines Delivering Simian Immunodeficiency Virus DNA.
Gordon SN, Kines RC, Kutsyna G, Ma ZM, Hryniewicz A, Roberts JN, Fenizia C, Hidajat R, Brocca-Cofano E, Cuburu N, Buck CB, Bernardo ML, Robert-Guroff M, Miller CJ, Graham BS, Lowy DR, Schiller JT, Franchini G.
J Immunol. 2011 Dec 14. [Epub ahead of print]

Vaccine
Whither Monkeypox vaccination.
Rimoin AW, Graham BS.
Vaccine. 2011 Dec 19. [Epub ahead of print]

Journal of Immonology
Clonotype and Repertoire Changes Drive the Functional Improvement of HIV-Specific CD8 T Cell Populations under Conditions of Limited Antigenic Stimulation.
Janbazian L, Price DA, Canderan G, Filali-Mouhim A, Asher TE, Ambrozak DR, Scheinberg P, Boulassel MR, Routy JP, Koup RA, Douek DC, Sekaly RP, Trautmann L.
J Immunol. 2011 Dec 30. [Epub ahead of print]

November

Immunology
Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation.
Gujer C, Sundling C, Seder RA, Karlsson Hedestam GB, Loré K.
Immunology. 2011 Nov;134(3):257-69. doi: 10.1111/j.1365-2567.2011.03484.x.

Journal of Virology
Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies.
Zhu Z, Qin HR, Chen W, Zhao Q, Shen X, Schutte R, Wang Y, Ofek G, Streaker E, Prabakaran P, Fouda GG, Liao HX, Owens J, Louder M, Yang Y, Klaric KA, Moody MA, Mascola JR, Scott JK, Kwong PD, Montefiori D, Haynes BF, Tomaras GD, Dimitrov DS.
J Virol. 2011 Nov;85(21):11401-8. Epub 2011 Aug 31.

Journal of Acquired Immune Deficiency Syndromes
Disease-modifying therapeutic concepts for HIV in the era of highly active antiretroviral therapy.
Butler SL, Valdez H, Westby M, Perros M, June CH, Jacobson JM, Levy Y, Cooper DA, Douek D, Lederman MM, Tebas P.
J Acquir Immune Defic Syndr. 2011 Nov 1;58(3):297-303.

Retrovirology
Mapping of positive selection sites in the HIV-1 genome in the context of RNA and protein structural constraints.
Snoeck J, Fellay J, Bartha I, Douek DC, Telenti A.
Retrovirology. 2011 Nov 1;8(1):87. [Epub ahead of print]

Science Translational Medicine
Epstein-barr virus: an important vaccine target for cancer prevention.
Cohen JI, Fauci AS, Varmus H, Nabel GJ.
Sci Transl Med. 2011 Nov 2;3(107):107fs7.

Public Library of Science ONE
Monitoring CD27 Expression to Evaluate Mycobacterium Tuberculosis Activity in HIV-1 Infected Individuals In Vivo.
Schuetz A, Haule A, Reither K, Ngwenyama N, Rachow A, Meyerhans A, Maboko L, Koup RA, Hoelscher M, Geldmacher C.
PLoS One. 2011;6(11):e27284. Epub 2011 Nov 7.

BMJ Open
A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults.
Minassian AM, Rowland R, Beveridge NE, Poulton ID, Satti I, Harris S, Poyntz H, Hamill M, Griffiths K, Sander CR, Ambrozak DR, Price DA, Hill BJ, Casazza JP, Douek DC, Koup RA, Roederer M, Winston A, Ross J, Sherrard J, Rooney G, Williams N, Lawrie AM, Fletcher HA, Pathan AA, McShane H.
BMJ Open. 2011 Nov 14;1(2):e000223. Print 2011.

Journal of Virology
Respiratory Syncytial Virus G Glycoprotein Interacts with DC-SIGN and L-SIGN to Activate ERK1 and ERK2.
Johnson TR, McLellan JS, Graham BS.
J Virol. 2011 Nov 16. [Epub ahead of print]

Respiratory Research
Aerosolized Adenovirus-vectored Vaccine as an Alternative Vaccine Delivery Method.
Roy CJ, Ault A, Sivasubramani SK, Gorres JP, Wei CJ, Andersen H, Gall J, Roederer M, Rao SS.
Respir Res. 2011 Nov 21;12(1):153. [Epub ahead of print]

Immunity
A Critical Role for STAT3 Transcription Factor Signaling in the Development and Maintenance of Human T Cell Memory.
Siegel AM, Heimall J, Freeman AF, Hsu AP, Brittain E, Brenchley JM, Douek DC, Fahle GH, Cohen JI, Holland SM, Milner JD.
Immunity. 2011 Nov 23;35(5):806-18.

Nature
Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9.
McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O'Dell S, Patel N, Shahzad-Ul-Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, Georgiev I, Do Kwon Y, Lee D, Louder MK, Moquin S, Schmidt SD, Yang ZY, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Burton DR, Koff WC, Walker LM, Phogat S, Wyatt R, Orwenyo J, Wang LX, Arthos J, Bewley CA, Mascola JR, Nabel GJ, Schief WR, Ward AB, Wilson IA, Kwong PD.
Nature. 2011 Nov 23. doi: 10.1038/nature10696. [Epub ahead of print]

October

Journal of Clinical Investigation
A high-throughput single-cell analysis of human CD8+ T cell functions reveals discordance for cytokine secretion and cytolysis.
Varadarajan N, Julg B, Yamanaka YJ, Chen H, Ogunniyi AO, McAndrew E, Porter LC, Piechocka-Trocha A, Hill BJ, Douek DC, Pereyra F, Walker BD, Love JC.
J Clin Invest. 2011 Nov 1;121(11):4322-4331. doi: 10.1172/JCI58653. Epub 2011 Oct 3.

Lancet Infectious Diseases
DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials.
Ledgerwood JE, Wei CJ, Hu Z, Gordon IJ, Enama ME, Hendel CS, McTamney PM, Pearce MB, Yassine HM, Boyington JC, Bailer R, Tumpey TM, Koup RA, Mascola JR, Nabel GJ, Graham BS; the VRC 306 Study Team.
Lancet Infect Dis. 2011 Oct 3. [Epub ahead of print]

Journal of Infectious Diseases
Future opportunities for passive immunity against viral diseases.
Graham BS.
J Infect Dis. 2011 Dec;204(11):1648-50. Epub 2011 Oct 12. No abstract available.

Philosophical Transactions of the Royal Society B: Biological Sciences
Progress in the rational design of an AIDS vaccine.
Nabel GJ, Kwong PD, Mascola JR.
Philos Trans R Soc Lond B Biol Sci. 2011 Oct 12;366(1579):2759-65.

Nature Structural & Molecular Biology
Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization.
Kim M, Sun ZY, Rand KD, Shi X, Song L, Cheng Y, Fahmy AF, Majumdar S, Ofek G, Yang Y, Kwong PD, Wang JH, Engen JR, Wagner G, Reinherz EL.
Nat Struct Mol Biol. 2011 Oct 16. doi: 10.1038/nsmb.2154. [Epub ahead of print]

Public Library of Science ONE
The Simian Immunodeficiency Virus Targets Central Cell Cycle Functions through Transcriptional Repression In vivo.
Hogerkorp CM, Nishimura Y, Song K, Martin MA, Roederer M.
PLoS One. 2011;6(10):e25684. Epub 2011 Oct 17.

Science
Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold.
Azoitei ML, Correia BE, Ban YE, Carrico C, Kalyuzhniy O, Chen L, Schroeter A, Huang PS, McLellan JS, Kwong PD, Baker D, Strong RK, Schief WR.
Science. 2011 Oct 21;334(6054):373-6.

Journal of Virology
Broad and Potent Neutralizing Antibody Responses Elicited in Natural HIV-2 Infection.
Kong R, Li H, Bibollet-Ruche F, Decker JM, Zheng NN, Gottlieb GS, Kiviat NB, Salif Sow P, Georgiev I, Hahn BH, Kwong PD, Robinson JE, Shaw GM.
J Virol. 2011 Oct 26. [Epub ahead of print]

Journal of Virology
Structural basis for norovirus inhibition and fucose mimicry by citrate.
Hansman GS, Shahzad-Ul-Hussan S, McLellan JS, Chuang GY, Georgiev I, Shimoike T, Katayama K, Bewley CA, Kwong PD.
J Virol. 2011 Oct 26. [Epub ahead of print]

Mucosal Immunology
Comparison of systemic and mucosal vaccination: impact on intravenous and rectal SIV challenge.
Bolton DL, Song K, Wilson RL, Kozlowski PA, Tomaras GD, Keele BF, Lovingood RV, Rao S, Roederer M.
Mucosal Immunol. 2011 Oct 26. doi: 10.1038/mi.2011.45. [Epub ahead of print]

September

Science
Live Attenuated Malaria Vaccine Designed to Protect through Hepatic CD8+ T Cell Immunity.
Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, Ockenhouse CF, Murphy JR, Komisar J, Thomas N, Loyevsky M, Birkett A, Plowe CV, Loucq C, Edelman R, Richie TL, Seder RA, Hoffman SL.
Science. 2011 Sep 8. [Epub ahead of print]

Public Library of Science ONE
GM-CSF Production Allows the Identification of Immunoprevalent Antigens Recognized by Human CD4+ T Cells Following Smallpox Vaccination.
Judkowski V, Bunying A, Ge F, Appel JR, Law K, Sharma A, Raja-Gabaglia C, Norori P, Santos RG, Giulianotti MA, Slifka MK, Douek DC, Graham BS, Pinilla C.
PLoS One. 2011;6(9):e24091. Epub 2011 Sep 9.

Public Library of Science ONE
Safety and Immunogenicity of an HIV Adenoviral Vector Boost after DNA Plasmid Vaccine Prime by Route of Administration: A Randomized Clinical Trial.
Koblin BA, Casapia M, Morgan C, Qin L, Wang ZM, Defawe OD, Baden L, Goepfert P, Tomaras GD, Montefiori DC, McElrath MJ, Saavedra L, Lau CY, Graham BS; The NIAID HIV Vaccine Trials Network.
PLoS One. 2011;6(9):e24517. Epub 2011 Sep 12.

Clinical and Vaccine Immunology
DNA Vaccination Elicits Protective Immune Responses against Pandemic and Classic Swine Influenza Viruses in Pigs.
Gorres JP, Lager KM, Kong WP, Royals M, Todd JP, Vincent AL, Wei CJ, Loving CL, Zanella EL, Janke B, Kehrli ME Jr, Nabel GJ, Rao SS.
Clin Vaccine Immunol. 2011 Sep 14. [Epub ahead of print]

Journal of Immunology
Hierarchical IL-5 Expression Defines a Subpopulation of Highly Differentiated Human Th2 Cells.
Upadhyaya B, Yin Y, Hill BJ, Douek DC, Prussin C.
J Immunol. 2011 Sep 15;187(6):3111-20. Epub 2011 Aug 17.

Nature Medicine
A human memory T cell subset with stem cell-like properties.
Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, Roederer M, Restifo NP.
Nat Med. 2011 Sep 18. doi: 10.1038/nm.2446. [Epub ahead of print]

Vaccine
Age-related changes in durability and function of vaccine-elicited influenza-specific CD4(+) T-cell responses.
Mahnke YD, Saqr A, Hazenfeld S, Brady RC, Roederer M, Subbramanian RA.
Vaccine. 2011 Sep 20. [Epub ahead of print]

Journal of Infectious Diseases
Timing of Plasmid Cytokine (IL-2/Ig) Administration Affects HIV-1 Vaccine Immunogenicity in HIV-Seronegative Subjects.
Baden LR, Blattner WA, Morgan C, Huang Y, Defawe OD, Sobieszczyk ME, Kochar N, Tomaras GD, McElrath MJ, Russell N, Brandariz K, Cardinali M, Graham BS, Barouch DH, Dolin R; the NIAID HIV Vaccine Trials Network 044 Study Team.
J Infect Dis. 2011 Sep 21. [Epub ahead of print]

Blood
SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.
Klatt NR, Vinton CL, Lynch RM, Canary LA, Ho J, Darrah PA, Estes JD, Seder RA, Moir SL, Brenchley JM.
Blood. 2011 Sep 29. [Epub ahead of print]

August

Public Library of Science ONE
A Phase IIA Randomized Clinical Trial of a Multiclade HIV-1 DNA Prime Followed by a Multiclade rAd5 HIV-1 Vaccine Boost in Healthy Adults (HVTN204).
Churchyard GJ, Morgan C, Adams E, Hural J, Graham BS, Moodie Z, Grove D, Gray G, Bekker LG, McElrath MJ, Tomaras GD, Goepfert P, Kalams S, Baden LR, Lally M, Dolin R, Blattner W, Kalichman A, Figueroa JP, Pape J, Schechter M, Defawe O, De Rosa SC, Montefiori DC, Nabel GJ, Corey L, Keefer MC; and the NIAID HIV Vaccine Trials Network.
PLoS One. 2011;6(8):e21225. Epub 2011 Aug 3.

ACS Chemical Biology
Structure-Based Identification and Neutralization Mechanism of Tyrosine Sulfate Mimetics That Inhibit HIV-1 Entry.
Acharya P, Dogo-Isonagie C, Lalonde JM, Lam SN, Leslie GJ, Louder MK, Frye LL, Debnath AK, Greenwood JR, Luongo TS, Martin L, Watts KS, Hoxie JA, Mascola JR, Bewley CA, Kwong PD.
ACS Chem Biol. 2011 Aug 5. [Epub ahead of print]

Science
Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing.
Wu X, Zhou T, Zhu J, Zhang B, Georgiev I, Wang C, Chen X, Longo NS, Louder M, McKee K, O'Dell S, Perfetto S, Schmidt SD, Shi W, Wu L, Yang Y, Yang ZY, Yang Z, Zhang Z, Bonsignori M, Crump JA, Kapiga SH, Sam NE, Haynes BF, Simek M, Burton DR, Koff WC, Doria-Rose N, Connors M; NISC Comparative Sequencing Program, Mullikin JC, Nabel GJ, Roederer M, Shapiro L, Kwong PD, Mascola JR.
Science. 2011 Aug 11. [Epub ahead of print]

Journal of Immunology
HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable.
De Rosa SC, Thomas EP, Bui J, Huang Y, Decamp A, Morgan C, Kalams SA, Tomaras GD, Akondy R, Ahmed R, Lau CY, Graham BS, Nabel GJ, McElrath MJ; the National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network.
J Immunol. 2011 Aug 15. [Epub ahead of print]

Journal of Virology
Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-infected Individuals.
Tomaras GD, Binley JM, Gray ES, Crooks ET, Osawa K, Moore PL, Tumba N, Tong T, Shen X, Yates NL, Decker J, Wibmer K, Gao F, Alam SM, Easterbrook P, Abdool-Karim S, Kamanga G, Crump JA, Cohen M, Shaw GM, Mascola JR, Haynes BF, Montefiori DC, Morris L.
J Virol. 2011 Aug 17. [Epub ahead of print]

Nature Medicine
CD8(+) cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates.
Sullivan NJ, Hensley L, Asiedu C, Geisbert TW, Stanley D, Johnson J, Honko A, Olinger G, Bailey M, Geisbert JB, Reimann KA, Bao S, Rao S, Roederer M, Jahrling PB, Koup RA, Nabel GJ.
Nat Med. Aug 21. doi: 10.1038/nm.2447. [Epub ahead of print]

Current Protocols in Immunology
Unbiased molecular analysis of T cell receptor expression using template-switch anchored rt-PCR.
Quigley MF, Almeida JR, Price DA, Douek DC.
Curr Protoc Immunol. 2011 Aug;Chapter 10:Unit10.33.

Cytometry A
High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.
Quigley MF, Almeida JR, Price DA, Douek DC.
Cytometry A. 2011 Aug;79(8):603-12. doi: 10.1002/cyto.a.21084. Epub 2011 Jul 6.

Cytometry A
Multiple stained samples are not appropriate compensation controls.
Roederer M.
Cytometry A. 2011 Aug;79(8):591-3. doi: 10.1002/cyto.a.21093. Epub 2011 Jun 14. No abstract available.

July

Gastroenterology
Host Response to Translocated Microbial Products Predicts Outcomes of Patients with HBV or HCV infection.
Sandler NG, Koh C, Roque A, Eccleston JL, Siegel RB, Demino M, Kleiner DE, Deeks SG, Liang TJ, Heller T, Douek DC.
Gastroenterology. 2011 Jul 1. [Epub ahead of print]

Blood
Escape from highly effective public CD8+ T-cell clonotypes by HIV.
Iglesias MC, Almeida JR, Fastenackels S, van Bockel DJ, Hashimoto M, Venturi V, Gostick E, Urrutia A, Wooldridge L, Clement M, Gras S, Wilmann PG, Autran B, Moris A, Rossjohn J, Davenport MP, Takiguchi M, Brander C, Douek DC, Kelleher AD, Price DA, Appay V.
Blood. 2011 Jul 6. [Epub ahead of print]

Cytometry Part A
High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses.
Pollara J, Hart L, Brewer F, Pickeral J, Packard BZ, Hoxie JA, Komoriya A, Ochsenbauer C, Kappes JC, Roederer M, Huang Y, Weinhold KJ, Tomaras GD, Haynes BF, Montefiori DC, Ferrari G.
Cytometry A. 2011 Aug;79(8):603-12. doi: 10.1002/cyto.a.21084. Epub 2011 Jul 6.

Science Translational Medicine
Vaccine design reaches the atomic level.
Kwong PD, Shapiro L.
Sci Transl Med. 2011 Jul 13;3(91):91ps29.

Journal of Virology
High functional avidity CTL responses to HLA-B-restricted Gag-derived epitopes associate with relative HIV control.
Berger CT, Frahm N, Price DA, Mothe B, Ghebremichael M, Hartman KL, Henry LM, Brenchley JM, Ruff LE, Venturi V, Pereyra F, Sidney J, Sette A, Douek DC, Walker BD, Kaufmann DE, Brander C.
J Virol. 2011 Jul 13. [Epub ahead of print]

Blood
Interleukin-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.
Lugli E, Mueller YM, Lewis MG, Villinger F, Katsikis PD, Roederer M.
Blood. 2011 Jul 14. [Epub ahead of print]

Journal of Virology
TRIM5 modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys.
Yeh WW, Rao SS, Lim SY, Zhang J, Hraber PT, Brassard LM, Luedemann C, Todd JP, Dodson A, Shen L, Buzby AP, Whitney JB, Korber BT, Nabel GJ, Mascola JR, Letvin NL.
J Virol. 2011 Jul 20. [Epub ahead of print]

Journal of Acquired Immune Deficiency Syndromes
Disease-Modifying Therapeutic Concepts for HIV in the Era of Highly Active Antiretroviral Therapy.
Butler SL, Valdez H, Westby M, Perros M, June CH, Jacobson JM, Levy Y, Cooper DA, Douek D, Lederman MM, Tebas P.
J Acquir Immune Defic Syndr. 2011 Jul 22. [Epub ahead of print]

Journal of Virology
Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors.
Bonsignori M, Hwang KK, Chen X, Tsao CY, Morris L, Gray E, Marshall DJ, Crump JA, Kapiga SH, Sam NE, Sinangil F, Pancera M, Yongping Y, Zhang B, Zhu J, Kwong PD, O'Dell S, Mascola JR, Wu L, Nabel GJ, Phogat S, Seaman MS, Whitesides JF, Moody MA, Kelsoe G, Yang X, Sodroski J, Shaw GM, Montefiori D, Kepler TB, Tomaras GD, Alam SM, Liao HX, Haynes BF.
J Virol. 2011 Jul 27. [Epub ahead of print]

Nature
Second messenger role for Mg2+ revealed by human T-cell immunodeficiency.
Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, Cohen JI, Uzel G, Su HC, Lenardo MJ.
Nature. 2011 Jul 27;475(7357):471-6. doi: 10.1038/nature10246.

June

The Journal of Biomolecular NMR
Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy.
Sastry M, Xu L, Georgiev IS, Bewley CA, Nabel GJ, Kwong PD.
J Biomol NMR. 2011 Jun 12. [Epub ahead of print]

Cytometry A
Multiple stained samples are not appropriate compensation controls.
Roederer M.
Cytometry A. 2011 Jun 14. doi: 10.1002/cyto.a.21093. [Epub ahead of print] No abstract available.

Journal of Molecular Biology
Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus.
McLellan JS, Correia BE, Chen M, Yang Y, Graham BS, Schief WR, Kwong PD.
J Mol Biol. 2011 Jun 24;409(5):853-66. Epub 2011 Apr 27.

Journal of Virology
Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01.
Li Y, O'Dell S, Walker LM, Wu X, Guenaga J, Feng Y, Schmidt SD, McKee K, Louder MK, Ledgerwood JE, Graham BS, Haynes BF, Burton DR, Wyatt RT, Mascola JR.
J Virol. 2011 Jun 29. [Epub ahead of print]

May

Science Translational Medicine
Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys.
Letvin NL, Rao SS, Montefiori DC, Seaman MS, Sun Y, Lim SY, Yeh WW, Asmal M, Gelman RS, Shen L, Whitney JB, Seoighe C, Lacerda M, Keating S, Norris PJ, Hudgens MG, Gilbert PB, Buzby AP, Mach LV, Zhang J, Balachandran H, Shaw GM, Schmidt SD, Todd JP, Dodson A, Mascola JR, Nabel GJ.
Sci Transl Med. 2011 May 4;3(81):81ra36.

Journal of Clinical Investigation
Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.
Rotger M, Dalmau J, Rauch A, McLaren P, Bosinger SE, Martinez R, Sandler NG, Roque A, Liebner J, Battegay M, Bernasconi E, Descombes P, Erkizia I, Fellay J, Hirschel B, Miró JM, Palou E, Hoffmann M, Massanella M, Blanco J, Woods M, Günthard HF, de Bakker P, Douek DC, Silvestri G, Martinez-Picado J, Telenti A.
J Clin Invest. 2011 Jun 1;121(6):2391-400. doi: 10.1172/JCI45235. Epub 2011 May 9.

Journal of Virology
Antibody-Dependent Cell-Mediated Cytotoxicity in Simian Immunodeficiency Virus-Infected Rhesus Monkeys.
Sun Y, Asmal M, Lane S, Permar SR, Schmidt SD, Mascola JR, Letvin NL.
J Virol. 2011 May 18. [Epub ahead of print]

Science Translational Medicine
Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity.
Hippen KL, Merkel SC, Schirm DK, Sieben CM, Sumstad D, Kadidlo DM, McKenna DH, Bromberg JS, Levine BL, Riley JL, June CH, Scheinberg P, Douek DC, Miller JS, Wagner JE, Blazar BR.
Sci Transl Med. 2011 May 18;3(83):83ra41.

Journal of Virology
Structure of the Respiratory Syncytial Virus Fusion Glycoprotein in the Post-fusion Conformation Reveals Preservation of Neutralizing Epitopes.
McLellan JS, Yang Y, Graham BS, Kwong PD.
J Virol. 2011 May 25. [Epub ahead of print]

April

Proceedings of the National Academy of Sciences of the USA
Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines.
Flatz L, Roychoudhuri R, Honda M, Filali-Mouhim A, Goulet JP, Kettaf N, Lin M, Roederer M, Haddad EK, Sékaly RP, Nabel GJ.
Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5724-9. Epub 2011 Mar 21.

Journal of Immunological Methods
Isolation of viable antigen-specific CD8(+) T cells based on membrane-bound tumor necrosis factor (TNF)-α expression.
Haney D, Quigley MF, Asher TE, Ambrozak DR, Gostick E, Price DA, Douek DC, Betts MR.
J Immunol Methods. 2011 Apr 8. [Epub ahead of print]

Journal of Clinical Investigation
Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.
Kastenmüller K, Wille-Reece U, Lindsay RW, Trager LR, Darrah PA, Flynn BJ, Becker MR, Udey MC, Clausen BE, Igyarto BZ, Kaplan DH, Kastenmüller W, Germain RN, Seder RA.
J Clin Invest. 2011 May 2;121(5):1782-96. doi: 10.1172/JCI45416. Epub 2011 Apr 11.

Proceedings of the National Academy of Sciences of the USA
Adenovirus type-35 vectors block human CD4+ T-cell activation via CD46 ligation.
Adams WC, Gujer C, McInerney G, Gall JG, Petrovas C, Hedestam GB, Koup RA, Loré K.
Proc Natl Acad Sci U S A. 2011 Apr 18. [Epub ahead of print]

Science Translational Medicine
HIV-1 Vaccines and Adaptive Trial Designs.
Corey L, Nabel GJ, Dieffenbach C, Gilbert P, Haynes BF, Johnston M, Kublin J, Lane HC, Pantaleo G, Picker LJ, Fauci AS.
Sci Transl Med. 2011 Apr 20;3(79):79ps13.

Journal of Virology
Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability.
Hansman GS, Biertümpfel C, Georgiev I, McLellan JS, Chen L, Zhou T, Katayama K, Kwong PD.
J Virol. 2011 Apr 27. [Epub ahead of print]

March

Journal of Virology
Antibody-dependent cell-mediated viral inhibition emerges after SIVmac251 infection of rhesus monkeys coincident with gp140 binding antibodies and is effective against neutralization-resistant viruses.
Asmal M, Sun Y, Lane S, Yeh W, Schmidt SD, Mascola JR, Letvin NL.
J Virol. 2011 Mar 30. [Epub ahead of print]

Proceedings of the National Academy of Sciences
Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines.
Flatz L, Roychoudhuri R, Honda M, Filali-Mouhim A, Goulet JP, Kettaf N, Lin M, Roederer M, Haddad EK, Sékaly RP, Nabel GJ.
Proc Natl Acad Sci U S A. 2011 Mar 21. [Epub ahead of print]

Blood
Evolution of the donor T cell repertoire in recipients in the second decade after allogeneic stem cell transplantation.
Le RQ, Melenhorst JJ, Battiwalla M, Hill B, Memon S, Savani BN, Shenoy A, Hensel NF, Koklanaris EK, Keyvanfar K, Hakim FT, Douek DC, Barrett AJ.
Blood. 2011 Mar 18. [Epub ahead of print]

Blood
Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T cell exhaustion in HIV infection.
Yamamoto T, Price DA, Casazza JP, Ferrari G, Nason M, Chattopadhyay PK, Roederer M, Gostick E, Katsikis PD, Douek DC, Haubrich R, Petrovas C, Koup RA.
Blood. 2011 Mar 11. [Epub ahead of print]

Journal of Infectious Diseases
A West Nile Virus DNA Vaccine Utilizing a Modified Promoter Induces Neutralizing Antibody in Younger and Older Healthy Adults in a Phase I Clinical Trial.
Ledgerwood JE, Pierson TC, Hubka SA, Desai N, Rucker S, Gordon IJ, Enama ME, Nelson S, Nason M, Gu W, Bundrant N, Koup RA, Bailer RT, Mascola JR, Nabel GJ, Graham BS; the VRC 303 Study Team.
J Infect Dis. 2011 Mar 16. [Epub ahead of print]

Nature
Vaccinate for the next H2N2 pandemic now.
Nabel GJ, Wei CJ, Ledgerwood JE.
Nature. 2011 Mar 10;471(7337):157-8.

Blood
Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques.
Waldmann TA, Lugli E, Roederer M, Perera LP, Smedley JV, Macallister RP, Goldman CK, Bryant BR, Decker JM, Fleisher TA, Lane HC, Sneller MC, Kurlander RJ, Kleiner DE, Pletcher JM, Figg WD, Yovandich JL, Creekmore SP.
Blood. 2011 Mar 8. [Epub ahead of print]

Journal of Immunology
A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing.
Venturi V, Quigley MF, Greenaway HY, Ng PC, Ende ZS, McIntosh T, Asher TE, Almeida JR, Levy S, Price DA, Davenport MP, Douek DC.
J Immunol. 2011 Apr 1;186(7):4285-94. Epub 2011 Mar 7.

Journal of Leukocyte Biology
IFN-{alpha} produced by human plasmacytoid dendritic cells enhances T cell-dependent naive B cell differentiation.
Gujer C, Sandgren KJ, Douagi I, Adams WC, Sundling C, Smed-Sörensen A, Seder RA, Karlsson Hedestam GB, Loré K.
J Leukoc Biol. 2011 Mar 29. [Epub ahead of print]

February

PLoS Pathogens
Genital Tract Sequestration of SIV following Acute Infection.
Whitney JB, Hraber PT, Luedemann C, Giorgi EE, Daniels MG, Bhattacharya T, Rao SS, Mascola JR, Nabel GJ, Korber BT, Letvin NL.
PLoS Pathog. 2011 Feb;7(2):e1001293. Epub 2011 Feb 17.

Immunology and Cell Biology
Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination.
Miles JJ, Douek DC, Price DA.
Immunol Cell Biol. 2011 Mar;89(3):375-87. Epub 2011 Feb 8.

PLoS Pathogens
Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection.
Ferrari G, Korber B, Goonetilleke N, Liu MK, Turnbull EL, Salazar-Gonzalez JF, Hawkins N, Self S, Watson S, Betts MR, Gay C, McGhee K, Pellegrino P, Williams I, Tomaras GD, Haynes BF, Gray CM, Borrow P, Roederer M, McMichael AJ, Weinhold KJ.
PLoS Pathog. 2011 Feb 10;7(2):e1001273.

Journal of Virology
Immunotypes of a Quaternary Site of HIV-1 Vulnerability and Their Recognition by Antibodies.
Wu X, Changela A, O'Dell S, Schmidt SD, Pancera M, Yang Y, Zhang B, Gorny MK, Phogat S, Robinson JE, Stamatatos L, Zolla-Pazner S, Kwong PD, Mascola JR.
J Virol. 2011 Feb 16. [Epub ahead of print]

Journal of Virology
Recombinant Adenovirus Serotypes 26 and 35 Vaccine Vectors Bypass Immunity to Ad5 and Protect Nonhuman Primates Against Ebolavirus Challenge.
Geisbert TW, Bailey M, Hensley L, Asiedu C, Geisbert J, Stanley D, Honko A, Johnson J, Mulangu S, Grazia Pau M, Custers J, Vellinga J, Hendriks J, Jahrling P, Roederer M, Goudsmit J, Koup R, Sullivan NJ.
J Virol. 2011 Feb 16. [Epub ahead of print]

January

Bioorganic & Medicinal Chemistry
Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening.
Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schön A, Freire E, Sodroski J, Smith AB 3rd.
Bioorg Med Chem. 2011 Jan 1;19(1):91-101. Epub 2010 Nov 26.

Immunological Reviews
Vaccines.
Douek DC, Nabel GJ.
Immunol Rev. 2011 Jan;239(1):5-7. doi: 10.1111/j.1600-065X.2010.00986.x.

Immunological Reviews
Biological challenges and technological opportunities for respiratory syncytial virus vaccine development.
Graham BS.
Immunol Rev. 2011 Jan;239(1):149-66. doi: 10.1111/j.1600-065X.2010.00972.x.

Biology of Blood and Marrow Transplantation
Alloreactivity Across HLA Barriers Is Mediated by Both Naïve and Antigen-Experienced T Cells.
Melenhorst JJ, Scheinberg P, Williams A, Ambrozak DR, Keyvanfar K, Smith M, McCoy JP Jr, Hensel NF, Douek DC, Barrett AJ.
Biol Blood Marrow Transplant. 2011 Jan 6. [Epub ahead of print]

Blood
Data quality in the study of the mechanisms of extracorporeal photochemotherapy.
George JF, Roederer M.
Blood. 2011 Jan 6;117(1):366-7

Cytometry
Heavy metal contaminants can eliminate quantum dot fluorescence.
Zarkowsky D, Lamoreaux L, Chattopadhyay P, Koup RA, Perfetto SP, Roederer M.
Cytometry A. 2011 Jan;79(1):84-9.

Cytometry
SPICE: Exploration and analysis of post-cytometric complex multivariate datasets.
Roederer M, Nozzi JL, Nason MC.
Cytometry A. 2011 Feb;79(2):167-74. doi: 10.1002/cyto.a.21015. Epub 2011 Jan 7.

Cytometry
Interpretation of cellular proliferation data: Avoid the panglossian.
Roederer M.
Cytometry A. 2011 Jan 12. [Epub ahead of print]

Cytometry
Interpretation of cellular proliferation data: Avoid the panglossian.
Roederer M.
Cytometry A. 2011 Feb;79(2):95-101. doi: 10.1002/cyto.a.21010. Epub 2011 Jan 12.

Journal of Virology
Ebolavirus Proteins Suppress siRNA Effects by Direct Interaction with the Mammalian RNAi Pathway.
Fabozzi G, Nabel CS, Dolan MA, Sullivan NJ.
J Virol. 2011 Jan 12. [Epub ahead of print]

Journal of Leukocyte Biology
IFN-{alpha} produced by human plasmacytoid dendritic cells enhances T cell-dependent naive B cell differentiation.
Gujer C, Sandgren KJ, Douagi I, Adams WC, Sundling C, Smed-Sörensen A, Seder RA, Hedestam GB, Loré K.
J Leukoc Biol. 2011 Jan 13. [Epub ahead of print]

Virology
Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.
Patterson LJ, Daltabuit-Test M, Xiao P, Zhao J, Hu W, Wille-Reece U, Brocca-Cofano E, Kalyanaraman VS, Kalisz I, Whitney S, Lee EM, Pal R, Montefiori DC, Dandekar S, Seder R, Roederer M, Wiseman RW, Hirsch V, Robert-Guroff M.
Virology. 2011 Jan 13. [Epub ahead of print]

AIDS Research and Human Retroviruses
Early Short-Term Antiretroviral Therapy Is Associated with a Reduced Prevalence of CD8(+)FoxP3(+) T Cells in Simian Immunodeficiency Virus-Infected Controller Rhesus Macaques.
George J, Cofano EB, Lybarger E, Louder M, Lafont BA, Mascola JR, Robert-Guroff M, Mattapallil JJ.
AIDS Res Hum Retroviruses. 2011 Jan 17. [Epub ahead of print]

AIDS Research and Human Retroviruses
HIV Type 1 Env Precursor Cleavage State Affects Recognition by Both Neutralizing and Nonneutralizing gp41 Antibodies.
Chakrabarti BK, Pancera M, Phogat S, O'Dell S, McKee K, Guenaga J, Robinson J, Mascola J, Wyatt RT.
AIDS Res Hum Retroviruses. 2011 Jan 19. [Epub ahead of print]

Journal of Infectious Diseases
Plasma Levels of Soluble CD14 Independently Predict Mortality in HIV Infection.
Sandler NG, Wand H, Roque A, Law M, Nason MC, Nixon DE, Pedersen C, Ruxrungtham K, Lewin SR, Emery S, Neaton JD, Brenchley JM, Deeks SG, Sereti I, Douek DC; for the INSIGHT SMART Study Group.
J Infect Dis. 2011 Jan 20. [Epub ahead of print]

Journal of Virology
SIVmac239{Delta}nef vaccination elicits different Tat28-35SL8-specific CD8+ T-cell clonotypes compared to a DNA prime/Ad5 boost regimen in rhesus macaques.
Burwitz BJ, Ende Z, Sudolcan B, Reynolds MR, Greene JM, Bimber BN, Almeida JR, Kurniawan M, Venturi V, Gostick E, Wiseman RW, Douek DC, Price DA, O'Connor DH.
J Virol. 2011 Jan 26. [Epub ahead of print]

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Last Updated January 03, 2012

Last Reviewed February 02, 2011