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Journal Publications, 2012

The NIH Library provides information about online journal access.

December

AIDS
Early immunologic and virologic predictors of clinical HIV-1 disease progression.
Mahnke YD, Song K, Sauer MM, Nason MC, Giret MT, Carvalho KI, Costa PR, Roederer M, Kallás EG.
AIDS. 2012 Dec 3. [Epub ahead of print]

Nature Protocols
Identification, isolation and in vitro expansion of human and nonhuman primate T stem cell memory cells.
Lugli E, Gattinoni L, Roberto A, Mavilio D, Price DA, Restifo NP, Roederer M.
Nat Protoc. 2012 Dec 6;8(1):33-42. doi: 10.1038/nprot.2012.143. Epub 2012 Dec 6.

Journal of Virology
Outer domain of HIV-1 gp120: Antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04.
Joyce MG, Kanekiyo M, Xu L, Biertümpfel C, Boyington JC, Moquin S, Shi W, Wu X, Yang ZY, Yang Y, Zhang B, Zheng A, Zhou T, Zhu J, Mascola JR, Kwong PD, Nabel GJ.
J Virol. 2012 Dec 12. [Epub ahead of print]

Journal of Immunological Methods
Optimization and qualification of an 8-color intracellular cytokine staining assay for quantifying T cell responses in rhesus macaques for pre-clinical vaccine studies.
Donaldson MM, Kao SF, Eslamizar L, Gee C, Koopman G, Lifton M, Schmitz JE, Sylwester AW, Wilson A, Hawkins N, Self SG, Roederer M, Foulds KE.
J Immunol Methods. 2012 Dec 14;386(1-2):10-21. doi: 10.1016/j.jim.2012.08.011. Epub 2012 Aug 28.

Bioinformatics
Data Exploration, Quality Control and Testing in Single-Cell qPCR-Based Gene Expression Experiments.
McDavid A, Finak G, Chattopadyay PK, Dominguez M, Lamoreaux L, Ma SS, Roederer M, Gottardo R.
Bioinformatics. 2012 Dec 24. [Epub ahead of print]

Infection and Immunity
Full-length P. Falciparum Circumsporozoite Protein Administered with Poly-ICLC or GLA/SE Elicits Potent Antibody and CD4+ T Cell Immunity and Protection in Mice.
Kastenmüller K, Espinosa DA, Trager L, Stoyanov C, Salazar AM, Pokalwar S, Singh S, Dutta S, Ockenhouse CF, Zavala F, Seder RA.
Infect Immun. 2012 Dec 28. [Epub ahead of print]

November

Nature Protocols
Quality assurance for polychromatic flow cytometry using a suite of calibration beads.
Perfetto SP, Ambrozak D, Nguyen R, Chattopadhyay PK, Roederer M.
Nat Protoc. 2012 Nov 8;7(12):2067-79. doi: 10.1038/nprot.2012.126. Epub 2012 Nov 8.
 
Journal of Clinical Investigation
Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses.
Cuburu N, Graham BS, Buck CB, Kines RC, Pang YY, Day PM, Lowy DR, Schiller JT.
J Clin Invest. 2012 Nov 12. doi:pii: 63287. 10.1172/JCI63287. [Epub ahead of print]
 
Nature
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
Huang J, Ofek G, Laub L, Louder MK, Doria-Rose NA, Longo NS, Imamichi H, Bailer RT, Chakrabarti B, Sharma SK, Alam SM, Wang T, Yang Y, Zhang B, Migueles SA, Wyatt R, Haynes BF, Kwong PD, Mascola JR, Connors M.
Nature. 2012 Nov 15;491(7424):406-12. doi: 10.1038/nature11544. Epub 2012 Sep 18.

Cytometry A
OMIP-015: Human regulatory and activated T-cells without intracellular staining.
Mahnke YD, Beddall MH, Roederer M.
Cytometry A. 2012 Nov 16. doi: 10.1002/cyto.a.22230. [Epub ahead of print]

Journal of Virology
Holoendemic Malaria Exposure is Associated with Altered Epstein-Barr Virus-Specific CD8+ T-Cell Differentiation.
Chattopadhyay PK, Chelimo K, Embury PB, Mulama DH, Sumba PO, Gostick E, Ladell K, Brodie TM, Vulule J, Roederer M, Moormann AM, Price DA.
J Virol. 2012 Nov 21. [Epub ahead of print]

Proceedings of the National Academy of Sciences of the USA
Most rhesus macaques infected with the CCR5-tropic SHIVAD8 generate cross-reactive antibodies that neutralize multiple HIV-1 strains.
Shingai M, Donau OK, Schmidt SD, Gautam R, Plishka RJ, Buckler-White A, Sadjadpour R, Lee WR, Labranche CC, Montefiori DC, Mascola JR, Nishimura Y, Martin MA.
Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19769-74. doi: 10.1073/pnas.1217443109. Epub 2012 Nov 5.

October

Cytometry A
OMIP-013: Differentiation of human T-cells.
Mahnke YD, Beddall MH, Roederer M.
Cytometry A. 2012 Nov;81(11):935-6. doi: 10.1002/cyto.a.22201. Epub 2012 Oct 1.

Gastroenterology
Characteristics of Congenital Hepatic Fibrosis in a Large Cohort of Patients With Autosomal Recessive Polycystic Kidney Disease.
Gunay-Aygun M, Font-Montgomery E, Lukose L, Gerstein MT, Piwnica-Worms K, Choyke P, Daryanani KT, Turkbey B, Fischer R, Bernardini I, Sincan M, Zhao X, Sandler NG, Roque A, Douek DC, Graf J, Huizing M, Bryant JC, Mohan P, Gahl WA, Heller T.
Gastroenterology. 2012 Oct 3. doi:pii: S0016-5085(12)01457-6. 10.1053/j.gastro.2012.09.056. [Epub ahead of print]

International Journal of Microbiology
Microbial translocation and infectious diseases: what is the link?
D'Ettorre G, Douek D, Paiardini M, Ceccarelli G, Vullo V.
Int J Microbiol. 2012;2012:356981. doi: 10.1155/2012/356981. Epub 2012 Oct 4.

AIDS Research and Human Retroviruses
The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120.
Karasavvas N, Billings E, Rao M, Williams C, Zolla-Pazner S, Bailer RT, Koup RA, Madnote S, Arworn D, Shen X, Tomaras GD, Currier JR, Jiang M, Magaret C, Andrews C, Gottardo R, Gilbert P, Cardozo TJ, Rerks-Ngarm S, Nitayaphan S, Pitisuttithum P, Kaewkungwal J, Paris R, Greene K, Gao H, Gurunathan S, Tartaglia J, Sinangil F, Korber BT, Montefiori DC, Mascola JR, Robb ML, Haynes BF, Ngauy V, Michael NL, Kim JH, de Souza For The Moph Taveg Collaboration MS.
AIDS Res Hum Retroviruses. 2012 Oct 4. [Epub ahead of print]

Cytometry A
RchyOptimyx: Cellular hierarchy optimization for flow cytometry.
Aghaeepour N, Jalali A, O'Neill K, Chattopadhyay PK, Roederer M, Hoos HH, Brinkman RR.
Cytometry A. 2012 Oct 8. doi: 10.1002/cyto.a.22209. [Epub ahead of print]

Journal of Virology
Distinct Evolutionary Pressures Underlie Diversity in Simian and Human Immunodeficiency Virus Lineages.
Fischer W, Apetrei C, Santiago ML, Li Y, Gautam R, Pandrea I, Shaw GM, Hahn BH, Letvin NL, Nabel GJ, Korber BT.
J Virol. 2012 Oct 10. [Epub ahead of print]

Journal of Immunology
Anti-HIV B Cell Lines as Candidate Vaccine Biosensors.
Ota T, Doyle-Cooper C, Cooper AB, Huber M, Falkowska E, Doores KJ, Hangartner L, Le K, Sok D, Jardine J, Lifson J, Wu X, Mascola JR, Poignard P, Binley JM, Chakrabarti BK, Schief WR, Wyatt RT, Burton DR, Nemazee D.
J Immunol. 2012 Oct 12. [Epub ahead of print]

September

Contemporary Clinical Trials
Randomization to standard and concise informed consent forms: development of evidence-based consent practices.
Enama ME, Hu Z, Gordon I, Costner P, Ledgerwood JE, Grady C; VRC 306 and 307 Consent Study Teams.
Contemp Clin Trials. 2012 Sep;33(5):895-902. Epub 2012 Apr 20.

Clinical and Vaccine Immunology
H5 DNA Influenza Vaccination is Immunogenic by Intramuscular and Intradermal Routes in Humans.
Ledgerwood JE, Hu Z, Gordon IJ, Yamshchikov G, Enama ME, Plummer S, Bailer R, Pearce MB, Tumpey TM, Koup RA, Mascola JR, Nabel GJ, Graham BS; the VRC 304 and VRC 305 Study Teams.
Clin Vaccine Immunol. 2012 Sep 5. [Epub ahead of print]

Journal of Immunology
Increased Memory Differentiation Is Associated with Decreased Polyfunctionality for HIV but Not for Cytomegalovirus-Specific CD8+ T Cells.
Riou C, Treurnicht F, Abrahams MR, Mlisana K, Liu MK, Goonetilleke N, Koup R, Roederer M, Abdool Karim S, de Bruyn G, Williamson C, Gray CM, Burgers WA; the CAPRISA 002 Study Team.
J Immunol. 2012 Sep 10. [Epub ahead of print]

Nature
Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2.
Rolland M, Edlefsen PT, Larsen BB, Tovanabutra S, Sanders-Buell E, Hertz T, Decamp AC, Carrico C, Menis S, Magaret CA, Ahmed H, Juraska M, Chen L, Konopa P, Nariya S, Stoddard JN, Wong K, Zhao H, Deng W, Maust BS, Bose M, Howell S, Bates A, Lazzaro M, O'Sullivan A, Lei E, Bradfield A, Ibitamuno G, Assawadarachai V, O'Connell RJ, Desouza MS, Nitayaphan S, Rerks-Ngarm S, Robb ML, McLellan JS, Georgiev I, Kwong PD, Carlson JM, Michael NL, Schief WR, Gilbert PB, Mullins JI, Kim JH.
Nature. 2012 Sep 10. doi: 10.1038/nature11519. [Epub ahead of print]

Blood
CD8 T cells express randomly selected KIRs with distinct specificities compared to NK cells.
Björkström NK, Béziat V, Cichocki F, Liu LL, Levine J, Larsson S, Koup RA, Anderson SK, Ljunggren HG, Malmberg KJ.
Blood. 2012 Sep 11. [Epub ahead of print]

Immunity
Human Antibodies that Neutralize HIV-1: Identification, Structures, and B Cell Ontogenies.
Kwong PD, Mascola JR.
Immunity. 2012 Sep 21;37(3):412-25. doi: 10.1016/j.immuni.2012.08.012.

August

Journal of Virology
HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully-Cleaved Envelope Glycoproteins.
Li Y, O'Dell S, Wilson R, Wu X, Schmidt SD, Hogerkorp CM, Louder MK, Longo NS, Poulsen C, Guenaga J, Chakrabarti B, Doria-Rose N, Roederer M, Connors M, Mascola JR, Wyatt RT.
J Virol. 2012 Aug 8. [Epub ahead of print]

Nature Reviews Microbiology
Microbial translocation in HIV infection: causes, consequences and treatment opportunities.
Sandler NG, Douek DC.
Nat Rev Microbiol. 2012 Aug 13;10(9):655-66. doi: 10.1038/nrmicro2848. Epub 2012 Aug 13.

Science Translational Medicine
Elicitation of broadly neutralizing influenza antibodies in animals with previous influenza exposure.
Wei CJ, Yassine HM, McTamney PM, Gall JG, Whittle JR, Boyington JC, Nabel GJ.
Sci Transl Med. 2012 Aug 15;4(147):147ra114.

Journal of Clinical Investigation
CD4 T follicular helper cell dynamics during SIV infection.
Petrovas C, Yamamoto T, Gerner MY, Boswell KL, Wloka K, Smith EC, Ambrozak DR, Sandler NG, Timmer KJ, Sun X, Pan L, Poholek A, Rao SS, Brenchley JM, Alam SM, Tomaras GD, Roederer M, Douek DC, Seder RA, Germain RN, Haddad EK, Koup RA.
J Clin Invest. 2012 Aug 27. pii: 63039. doi: 10.1172/JCI63039. [Epub ahead of print]

Journal of Virology
Epitope mapping of broadly neutralizing human HIV-2 monoclonal antibodies.
Kong R, Li H, Georgiev I, Changela A, Bibollet-Ruche F, Decker JM, Rowland-Jones SL, Jaye A, Guan Y, Lewis GK, Langedijk JP, Hahn BH, Kwong PD, Robinson JE, Shaw GM.
J Virol. 2012 Aug 29. [Epub ahead of print]

Nature
Structural and genetic basis for development of broadly neutralizing influenza antibodies.
Lingwood D, McTamney PM, Yassine HM, Whittle JR, Guo X, Boyington JC, Wei CJ, Nabel GJ.
Nature. 2012 Aug 29. doi: 10.1038/nature11371. [Epub ahead of print]

July

The Journal of the International AIDS Society
The changing face of HIV vaccine research.
Kwong PD, Mascola JR, Nabel GJ.
J Int AIDS Soc. 2012 Jul 5;15(2):1-6. doi: 10.7448/IAS.15.2.17407.

Bioinformatics
Computational Prediction of N-linked Glycosylation Incorporating Structural Properties and Patterns.
Chuang GY, Boyington JC, Joyce MG, Zhu J, Nabel GJ, Kwong PD, Georgiev I.
Bioinformatics. 2012 Jul 10. [Epub ahead of print]

Science Translational Medicine
High-Resolution Definition of Vaccine-Elicited B Cell Responses Against the HIV Primary Receptor Binding Site.
Sundling C, Li Y, Huynh N, Poulsen C, Wilson R, O'Dell S, Feng Y, Mascola JR, Wyatt RT, Karlsson Hedestam GB.
Sci Transl Med. 2012 Jul 11;4(142):142ra96.

Journal of Immunology
Recombinatorial Biases and Convergent Recombination Determine Interindividual TCRβ Sharing in Murine Thymocytes.
Li H, Ye C, Ji G, Wu X, Xiang Z, Li Y, Cao Y, Liu X, Douek DC, Price DA, Han J.
J Immunol. 2012 Jul 23. [Epub ahead of print]

Immunity
T Cell Assays and MIATA: The Essential Minimum for Maximum Impact.
Britten CM, Janetzki S, Butterfield LH, Ferrari G, Gouttefangeas C, Huber C, Kalos M, Levitsky HI, Maecker HT, Melief CJ, O'Donnell-Tormey J, Odunsi K, Old LJ, Ottenhoff TH, Ottensmeier C, Pawelec G, Roederer M, Roep BO, Romero P, van der Burg SH, Walter S, Hoos A, Davis MM.
Immunity. 2012 Jul 27;37(1):1-2.

June

Journal of Virology
The effect of priming with H1N1 influenza viruses of variable antigenic distance on challenge with 2009 pandemic H1N1 virus.
O'Donnell CD, Wright A, Vogel L, Wei CJ, Nabel GJ, Subbarao K.
J Virol. 2012 Jun 6. [Epub ahead of print]

Journal of Virology
Antibody-Dependent Cellular Cytotoxicity Against Primary HIV-Infected CD4+ T Cells is Directly Associated with the Magnitude of Surface IgG Binding.
Smalls-Mantey A, Doria-Rose N, Klein R, Patamawenu A, Migueles SA, Ko SY, Hallahan CW, Wong H, Liu B, You L, Scheid J, Kappes JC, Ochsenbauer C, Nabel GJ, Mascola JR, Connors M.
J Virol. 2012 Jun 6. [Epub ahead of print]

Nature Immunology
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BD.
Nat Immunol. 2012 Jun 10;13(7):691-700. doi: 10.1038/ni.2342.

Journal of Virology
Lineage-specific Differences Between Human and Simian Immunodeficiency Virus Regulation of gp120 Trimer Association and CD4 Binding.
Finzi A, Pacheco B, Xiang SH, Pancera M, Herschhorn A, Wang L, Zeng X, Desormeaux A, Kwong PD, Sodroski J.
J Virol. 2012 Jun 13. [Epub ahead of print]

AIDS
CD8+ T cells in preventing HIV infection and disease.
McDermott AB, Koup RA.
AIDS. 2012 Jun 19;26(10):1281-92.

AIDS
The design and evaluation of HIV-1 vaccines.
Saunders KO, Rudicell RS, Nabel GJ.
AIDS. 2012 Jun 19;26(10):1293-302.

Vaccine
Priming T-cell responses with recombinant measles vaccine vector in a heterologous prime-boost setting in non-human primates.
Bolton DL, Santra S, Swett C, Custers J, Song K, Balachandran H, Kozlowski PA, Letvin N, Roederer M, Radošević K.

May

Human Vaccines & Immunotherapeutics
Background morbidity in HIV vaccine trial participants from various geographic regions as assessed by unsolicited adverse events.
Schmidt C, Smith C, Barin B, Bakhtyari A, Bart PA, Bekker LG, Chomba E, Clumeck N, Ho D, Hoosen A, Jaoko W, Kaleebu P, Karita E, Keefer MC, van Lunzen J, McMichael A, Mehendale S, Peters B, Ramanathan V, Robinson A, Rockstroh J, Vardas E, Vets E, Weber J, Graham BS, Than S, Excler JL, Kochhar S, Ho M, Heald A, Fast PE.
Hum Vaccin Immunother. 2012 May 1;8(5). [Epub ahead of print]

Immunobiology
NKT and MAIT invariant TCRα sequences can be produced efficiently by VJ gene recombination.
Greenaway HY, Ng B, Price DA, Douek DC, Davenport MP, Venturi V.
Immunobiology. 2012 May 1. [Epub ahead of print]

Current Opinion in Virology
Ebolavirus vaccines for humans and apes.
Fausther-Bovendo H, Mulangu S, Sullivan NJ.
Curr Opin Virol. 2012 May 3. [Epub ahead of print]

Journal of Immunology
BLyS-Mediated Modulation of Naive B Cell Subsets Impacts HIV Env-Induced Antibody Responses.
Dosenovic P, Soldemo M, Scholz JL, O'Dell S, Grasset EK, Pelletier N, Karlsson MC, Mascola JR, Wyatt RT, Cancro MP, Karlsson Hedestam GB.
J Immunol. 2012 May 4. [Epub ahead of print]

Journal of Virology
The Development of CD4 Binding Site Antibodies During HIV-1 Infection.
Lynch RM, Tran L, Louder MK, Schmidt SD, Cohen M; the CHAVI 001 clinical team, Dersimonian R, Euler Z, Gray ES, Abdool Karim S, Kirchherr J, Montefiori DC, Sibeko S, Soderberg K, Tomaras G, Yang ZY, Nabel GJ, Schuitemaker H, Morris L, Haynes BF, Mascola JR.
J Virol. 2012 May 9. [Epub ahead of print]

Journal of Medicinal Chemistry
Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1.
Curreli F, Choudhury S, Pyatkin I, Zagorodnikov VP, Bulay AK, Altieri A, Kwon YD, Kwong PD, Debnath AK.
J Med Chem. 2012 May 24;55(10):4764-75. Epub 2012 May 10.

Journal of Immunology
Type I IFN Induced by Adenovirus Serotypes 28 and 35 Has Multiple Effects on T Cell Immunogenicity.
Johnson MJ, Petrovas C, Yamamoto T, Lindsay RW, Loré K, Gall JG, Gostick E, Lefebvre F, Cameron MJ, Price DA, Haddad E, Sekaly RP, Seder RA, Koup RA.
J Immunol. 2012 May 14. [Epub ahead of print]

Journal of Virology
Gene-based vaccination with a mis-matched envelope protects against simian immunodeficiency virus infection in non-human primates.
Flatz L, Cheng C, Wang L, Foulds K, Ko SY, Kong WP, Roychoudhuri R, Shi W, Bao S, Todd JP, Asmal M, Shen L, Donaldson M, Schmidt SD, Gall J, Pinschewer DD, Letvin NL, Rao S, Mascola JR, Roederer M, Nabel GJ.
J Virol. 2012 May 16. [Epub ahead of print]

Journal of Virology
A Short Segment of the HIV-1 gp120 V1/V2 Region Is a Major Determinant of Resistance to V1/V2 Neutralizing Antibodies.
Doria-Rose NA, Georgiev I, O'Dell S, Chuang GY, Staupe RP, McLellan JS, Gorman J, Pancera M, Bonsignori M, Haynes BF, Burton DR, Koff WC, Kwong PD, Mascola JR.
J Virol. 2012 May 23. [Epub ahead of print]

Journal of Virology
A specific domain of the Chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design.
Akahata W, Nabel GJ.
J Virol. 2012 May 30. [Epub ahead of print]

Journal of Virology
Pathogenicity and Mucosal Transmissibility of R5-Tropic Simian/Human Immunodeficiency Viruses SHIVAD8 in Rhesus Macaques: Implications for their Use in Vaccine Studies.
Gautam R, Nishimura Y, Lee WR, Donau O, Buckler-White A, Shingai M, Sadjadpour R, Schmidt SD, Labranche CC, Keele BF, Montefiori D, Mascola JR, Martin MA.
J Virol. 2012 May 30. [Epub ahead of print]

April

Journal of Virology
Differential Gag-specific polyfunctional T cell maturation patterns in HIV-1 elite controllers.
Ferrando-Martínez S, Casazza JP, Leal M, Machmach K, Muñoz-Fernández MÁ, Viciana P, Koup RA, Ruiz-Mateos E.
J Virol. 2012 Apr;86(7):3667-74. Epub 2012 Jan 25.

Trends in Immunology
A deep profiler's guide to cytometry.
Bendall SC, Nolan GP, Roederer M, Chattopadhyay PK.
Trends Immunol. 2012 Apr 2. [Epub ahead of print]

Public Library of Science One
Decreased Pre-existing Ad5 Capsid and Ad35 Neutralizing Antibodies Increase HIV-1 Infection Risk in the Step Trial Independent of Vaccination.
Cheng C, Wang L, Gall JG, Nason M, Schwartz RM, McElrath MJ, Derosa SC, Hural J, Corey L, Buchbinder SP, Nabel GJ.
PLoS One. 2012;7(3):e33969. Epub 2012 Apr 4.

New England Journal of Medicine
Immune-correlates analysis of an HIV-1 vaccine efficacy trial.
Haynes BF, Gilbert PB, McElrath MJ, Zolla-Pazner S, Tomaras GD, Alam SM, Evans DT, Montefiori DC, Karnasuta C, Sutthent R, Liao HX, DeVico AL, Lewis GK, Williams C, Pinter A, Fong Y, Janes H, DeCamp A, Huang Y, Rao M, Billings E, Karasavvas N, Robb ML, Ngauy V, de Souza MS, Paris R, Ferrari G, Bailer RT, Soderberg KA, Andrews C, Berman PW, Frahm N, De Rosa SC, Alpert MD, Yates NL, Shen X, Koup RA, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Kim JH.
N Engl J Med. 2012 Apr 5;366(14):1275-86.

Cytometry A
Brilliant violet fluorophores: A new class of ultrabright fluorescent compounds for immunofluorescence experiments.
Chattopadhyay PK, Gaylord B, Palmer A, Jiang N, Raven MA, Lewis G, Reuter MA, Nur-Ur Rahman AK, Price DA, Betts MR, Roederer M.
Cytometry A. 2012 Apr 6. doi: 10.1002/cyto.a.22043. [Epub ahead of print]

Virology
Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi-valent mosaic and consensus immunogens.
Santra S, Muldoon M, Watson S, Buzby A, Balachandran H, Carlson KR, Mach L, Kong WP, McKee K, Yang ZY, Rao SS, Mascola JR, Nabel GJ, Korber BT, Letvin NL.
Virology. 2012 Apr 20. [Epub ahead of print]

Journal of Medicinal Chemistry
Design, synthesis and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1.
Curreli F, Choudhury S, Pyatkin I, Zagorodnikov VP, Bulay AK, Altieri A, Kwon YD, Kwong PD, Debnath AK.
J Med Chem. 2012 Apr 23. [Epub ahead of print]

Journal of Medicinal Chemistry
Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors.
Lalonde JM, Kwon YD, Jones DM, Sun AW, Courter JR, Soeta T, Kobayashi T, Princiotto AM, Wu X, Schön A, Freire E, Kwong PD, Mascola JR, Sodroski J, Madani N, Smith AB 3rd.
J Med Chem. 2012 Apr 23. [Epub ahead of print]

Journal of Virology
Envelope variable region 4 is the first target of neutralizing antibodies in early simian immunodeficiency virus mac251 infection of rhesus monkeys.
Yeh WW, Brassard LM, Miller CA, Basavapathruni A, Zhang J, Rao SS, Nabel GJ, Mascola JR, Letvin NL, Seaman MS.
J Virol. 2012 Apr 24. [Epub ahead of print]

March

Trends in Immunology
Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection.
Geldmacher C, Koup RA.
Trends Immunol. 2012 Mar 5. [Epub ahead of print]

The Journal of Biological Chemistry
Peptides from the second extracellular loop of the C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.
Dogo-Isonagie C, Lam S, Gustchina E, Acharya P, Yang Y, Shahzad-Ul-Hussan S, Clore GM, Kwong PD, Bewley CA.
J Biol Chem. 2012 Mar 8. [Epub ahead of print]

Journal of Virology
Selection Pressure on HIV-1 Envelope by Broadly Neutralizing Antibodies to the Conserved CD4-Binding Site.
Wu X, Wang C, O'Dell S, Li Y, Keele BF, Yang Z, Imamichi H, Doria-Rose N, Hoxie JA, Connors M, Shaw GM, Wyatt RT, Mascola JR.
J Virol. 2012 Mar 14. [Epub ahead of print]

Journal of Virology
Virus inhibition activity of effector memory CD8+ T cells determines Simian Immunodeficiency Virus load in vaccinated monkeys after vaccine breakthrough infection.
Yamamoto T, Johnson MJ, Price DA, Wolinsky DI, Almeida JR, Petrovas C, Nason M, Yeh WW, Shen L, Roederer M, Rao SS, McDermott AB, Lefebvre F, Nabel GJ, Haddad EK, Letvin NL, Douek DC, Koup RA.
J Virol. 2012 Mar 14. [Epub ahead of print]

Cytometry Part A
OMIP-005: Quality and phenotype of antigen-responsive rhesus macaque T cells.
Foulds KE, Donaldson M, Roederer M.
Cytometry A. 2012 Mar 21. doi: 10.1002/cyto.a.22008. [Epub ahead of print] No abstract available.

Cytometry Part A
OMIP-009: Characterization of antigen-specific human T-cells.
Lamoreaux L, Koup RA, Roederer M.
Cytometry A. 2012 Mar 21. doi: 10.1002/cyto.a.22042. [Epub ahead of print] No abstract available.

AIDS
CD8 T cells in PreventingHIV Infection and Disease.
McDermott AB, Koup RA.
AIDS. 2012 Mar 23. [Epub ahead of print] No abstract available.

Vaccine
Immunogenicity and clinical protection against equine influenza by gene-based DNA vaccination of ponies.
Ault A, Zajac AM, Kong WP, Gorres JP, Royals M, Wei CJ, Bao S, Yang ZY, Reedy SE, Sturgill TL, Page AE, Donofrio-Newman J, Adams AA, Balasuriya UB, Horohov DW, Chambers TM, Nabel GJ, Rao SS.
Vaccine. 2012 Mar 23. [Epub ahead of print]

Proceedings of the National Academy of Sciences USA
Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops.
Kwon YD, Finzi A, Wu X, Dogo-Isonagie C, Lee LK, Moore LR, Schmidt SD, Stuckey J, Yang Y, Zhou T, Zhu J, Vicic DA, Debnath AK, Shapiro L, Bewley CA, Mascola JR, Sodroski JG, Kwong PD.
Proc Natl Acad Sci U S A. 2012 Mar 26. [Epub ahead of print]

February

Journal of Virology
Two Distinct Broadly Neutralizing Antibody Specificities of Different Clonal Lineages in a Single HIV-1-infected Donor: Implications for Vaccine Design.
Bonsignori M, Montefiori DC, Wu X, Chen X, Hwang KK, Tsao CY, Kozink DM, Parks RJ, Tomaras GD, Crump JA, Kapiga SH, Sam NE, Kwong PD, Kepler TB, Liao HX, Mascola JR, Haynes BF.
J Virol. 2012 Feb 1. [Epub ahead of print]

Journal of Virology
PG V04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.
Falkowska E, Ramos A, Feng Y, Zhou T, Moquin S, Walker LM, Wu X, Seaman MS, Wrin T, Kwong PD, Wyatt RT, Mascola JR, Poignard P, Burton DR.
J Virol. 2012 Feb 15. [Epub ahead of print]

Journal of Biological Chemistry
Biochemically Defined HIV-1 Envelope Glycoprotein Variant Immunogens Display Differential Binding and Neutralizing Specificities to the CD4-binding Site.
Feng Y, McKee K, Tran K, O'Dell S, Schmidt SD, Phogat A, Forsell MN, Karlsson Hedestam GB, Mascola JR, Wyatt RT.
J Biol Chem. 2012 Feb 17;287(8):5673-86. Epub 2011 Dec 13.

Journal of General Virology
Attenuation of CD4+ T Cell Function by Human Adenovirus Type-35 is Mediated by the Knob Protein.
Adams WC, Berenson RJ, Karlsson Hedestam GB, Lieber A, Koup RA, Loré K.
J Gen Virol. 2012 Feb 22. [Epub ahead of print]

Methods
Cytometry: Today's technology and tomorrow's horizons.
Chattopadhyay P, Roederer M.
Methods. 2012 Feb 25. [Epub ahead of print]

Bioinformatics
Early Immunologic Correlates of HIV Protection can be Identified from Computational Analysis of Complex Multivariate T-cell Flow Cytometry Assays.
Aghaeepour N, Chattopadhyay PK, Ganesan A, O'Neill K, Zare H, Jalali A, Hoos HH, Roederer M, Brinkman RR.
Bioinformatics. 2012 Feb 29. [Epub ahead of print]

Science Translational Medicine
Productive Replication of Ebola Virus Is Regulated by the c-Abl1 Tyrosine Kinase.
García M, Cooper A, Shi W, Bornmann W, Carrion R, Kalman D, Nabel GJ.
Sci Transl Med. 2012 Feb 29;4(123):123ra24.

January

Blood
Selective expansion of polyfunctional pathogen-specific CD4+ T cells in HIV-1-infected patients with immune reconstitution inflammatory syndrome.
Mahnke YD, Greenwald JH, Dersimonian R, Roby G, Antonelli LR, Sher A, Roederer M, Sereti I.
Blood. 2012 Jan 4. [Epub ahead of print]

Journal of Virology
Filoviruses Require Endosomal Cysteine Proteases for Entry But Exhibit Distinct Protease Preferences.
Misasi J, Chandran K, Yang JY, Considine B, Filone CM, Côté M, Sullivan N, Fabozzi G, Hensley L, Cunningham J.
J Virol. 2012 Jan 11. [Epub ahead of print]

Journal of Immunology
Targeting the vaginal mucosa with human papillomavirus pseudovirion vaccines delivering simian immunodeficiency virus DNA.
Gordon SN, Kines RC, Kutsyna G, Ma ZM, Hryniewicz A, Roberts JN, Fenizia C, Hidajat R, Brocca-Cofano E, Cuburu N, Buck CB, Bernardo ML, Robert-Guroff M, Miller CJ, Graham BS, Lowy DR, Schiller JT, Franchini G.
J Immunol. 2012 Jan 15;188(2):714-23. Epub 2011 Dec 14.

Journal of Virology
HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes.
Doria-Rose NA, Louder MK, Yang Z, O'Dell S, Nason M, Schmidt SD, McKee K, Seaman MS, Bailer RT, Mascola JR.
J Virol. 2012 Jan 18. [Epub ahead of print]

Journal of Virology
Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle.
Hansman GS, Taylor DW, McLellan JS, Smith TJ, Georgiev I, Tame JR, Park SY, Yamazaki M, Gondaira F, Miki M, Katayama K, Murata K, Kwong PD.
J Virol. 2012 Jan 25. [Epub ahead of print]

Journal of Virology
HLA B*5701+ Long-Term Nonprogressors/Elite Controllers are not Distinguished from Progressors by the Clonal Composition of HIV-Specific CD8+ T-Cells.
Mendoza D, Royce C, Ruff LE, Ambrozak DR, Quigley MF, Dang T, Venturi V, Price DA, Douek DC, Migueles SA, Connors M.
J Virol. 2012 Jan 25. [Epub ahead of print]

New England Journal of Medicine
Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.
Ombrello MJ, Remmers EF, Sun G, Freeman AF, Datta S, Torabi-Parizi P, Subramanian N, Bunney TD, Baxendale RW, Martins MS, Romberg N, Komarow H, Aksentijevich I, Kim HS, Ho J, Cruse G, Jung MY, Gilfillan AM, Metcalfe DD, Nelson C, O'Brien M, Wisch L, Stone K, Douek DC, Gandhi C, Wanderer AA, Lee H, Nelson SF, Shianna KV, Cirulli ET, Goldstein DB, Long EO, Moir S, Meffre E, Holland SM, Kastner DL, Katan M, Hoffman HM, Milner JD.
N Engl J Med. 2012 Jan 26;366(4):330-8. Epub 2012 Jan 11.

Nature Medicine
Preexisting influenza-specific CD4(+) T cells correlate with disease protection against influenza challenge in humans.
Wilkinson TM, Li CK, Chui CS, Huang AK, Perkins M, Liebner JC, Lambkin-Williams R, Gilbert A, Oxford J, Nicholas B, Staples KJ, Dong T, Douek DC, McMichael AJ, Xu XN.
Nat Med. 2012 Jan 29. doi: 10.1038/nm.2612. [Epub ahead of print]

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Last Updated November 06, 2012