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Journal Publications, 2013

The NIH Library provides information about online journal access.

December

Journal of Immunological Methods

Optimization and validation of the TZM-bl assay for standardized assessments of neutralizing antibodies against HIV-1.
Sarzotti-Kelsoe M, Bailer RT, Turk E, Lin CL, Bilska M, Greene KM, Gao H, Todd CA, Ozaki DA, Seaman MS, Mascola JR, Montefiori DC.
J Immunol Methods. 2013 Dec 1. pii: S0022-1759(13)00359-1. doi: 10.1016/j.jim.2013.11.022. [Epub ahead of print]

Virology Journal

Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models.
Lacerda M, Moore PL, Ngandu NK, Seaman M, Gray ES, Murrell B, Krishnamoorthy M, Nonyane M, Madiga M, Wibmer CK, Sheward D, Bailer RT, Gao H, Greene KM, Karim SS, Mascola JR, Korber BT, Montefiori DC, Morris L, Williamson C, Seoighe C; CAVD-NSDP Consortium.
Virol J. 2013 Dec 2;10(1):347. doi: 10.1186/1743-422X-10-347.

Vaccine

Type I interferon-dependent activation of NK cells by rAd28 or rAd35, but not rAd5, leads to loss of vector-insert expression.
Johnson MJ, Björkström NK, Petrovas C, Liang F, Gall JG, Loré K, Koup RA.
Vaccine. 2013 Dec 7. pii: S0264-410X(13)01589-2. doi: 10.1016/j.vaccine.2013.11.055. [Epub ahead of print]

Retrovirology

HIV integration and T cell death: additional commentary.
Cooper A, García M, Petrovas C, Yamamoto T, Koup RA, Nabel GJ.
Retrovirology. 2013 Dec 9;10:150. doi: 10.1186/1742-4690-10-150.

Journal of Virology

Structural Basis for HIV-1 Neutralization by 2F5-like Antibodies m66 and m66.6.
Ofek G, Zirkle B, Yang Y, Zhu Z, McKee K, Zhang B, Chuang GY, Georgiev IS, O'Dell S, Doria-Rose N, Mascola JR, Dimitrov DS, Kwong PD.
J Virol. 2013 Dec 11. [Epub ahead of print]

Journal of Virology

Global Panel of HIV-1 Env Reference Strains for Standardized Assessments of Vaccine-Elicited Neutralizing Antibodies.
Decamp A, Hraber P, Bailer RT, Seaman MS, Ochsenbauer C, Kappes J, Gottardo R, Edlefsen P, Self S, Tang H, Greene K, Gao H, Daniell X, Sarzotti-Kelsoe M, Gorny MK, Zolla-Pazner S, Labranche CC, Mascola JR, Korber BT, Montefiori DC.
J Virol. 2013 Dec 18. [Epub ahead of print]

Nature

Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.
Roederer M, Keele BF, Schmidt SD, Mason RD, Welles HC, Fischer W, Labranche C, Foulds KE, Louder MK, Yang ZY, Todd JP, Buzby AP, Mach LV, Shen L, Seaton KE, Ward BM, Bailer RT, Gottardo R, Gu W, Ferrari G, Alam SM, Denny TN, Montefiori DC, Tomaras GD, Korber BT, Nason MC, Seder RA, Koup RA, Letvin NL, Rao SS, Nabel GJ, Mascola JR.
Nature. 2013 Dec 18. doi: 10.1038/nature12893. [Epub ahead of print]

AIDS

Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection.
Hraber P, Seaman MS, Bailer RT, Mascola JR, Montefiori DC, Korber BT.
AIDS. 2013 Dec 19. [Epub ahead of print]

November

Archives of Virology

Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA.
Kuhn JH, Bào Y, Bavari S, Becker S, Bradfute S, Brauburger K, Rodney Brister J, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST.
Arch Virol. 2013 Nov 5.

European Journal of Immunology

The who's who of T-cell differentiation: Human memory T-cell subsets.
Mahnke YD, Brodie TM, Sallusto F, Roederer M, Lugli E.
Eur J Immunol. 2013 Nov;43(11):2797-809.

Virology

Chemical cross-linking of HIV-1 Env for direct TLR7/8 ligand conjugation compromises recognition of conserved antigenic determinants.
Feng Y, Forsell MN, Flynn B, Adams W, Loré K, Seder R, Wyatt RT, Karlsson Hedestam GB.
Virology. 2013 Nov;446(1-2):56-65.

Science

Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
McLellan JS, Chen M, Joyce MG, Sastry M, Stewart-Jones GB, Yang Y, Zhang B, Chen L, Srivatsan S, Zheng A, Zhou T, Graepel KW, Kumar A, Moin S, Boyington JC, Chuang GY, Soto C, Baxa U, Bakker AQ, Spits H, Beaumont T, Zheng Z, Xia N, Ko SY, Todd JP, Rao S, Graham BS, Kwong PD.
Science. 2013 Nov 1;342(6158):592-8.

Journal of Virology

Differential impact of magnitude, polyfunctional capacity and specificity of HIV-specific CD8+ T cell responses on HIV viral set point.
Riou C, Burgers WA, Mlisana K, Koup RA, Roederer M, Abdool Karim SS, Williamson C, Gray CM.
J Virol. 2013 Nov 13.

Proceedings of the National Academy of Sciences USA

The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time.
Josefsson L, von Stockenstrom S, Faria NR, Sinclair E, Bacchetti P, Killian M, Epling L, Tan A, Ho T, Lemey P, Shao W, Hunt PW, Somsouk M, Wylie W, Douek DC, Loeb L, Custer J, Hoh R, Poole L, Deeks SG, Hecht F, Palmer S.
Proc Natl Acad Sci U S A. 2013 Nov 25.

Journal of Immunological Methods

Optimization and Validation of the TZM-bl Assay for Standardized Assessments of Neutralizing Antibodies Against HIV-1.
Sarzotti-Kelsoe M, Bailer RT, Turk E, Lin CL, Bilska M, Greene KM, Gao H, Todd CA, Ozaki DA, Seaman MS, Mascola JR, Montefiori DC.
J Immunol Methods. 2013 Nov 28.

October

Expert Review of Clinical Immunology

Two demyelinating diseases in the brain of a single patient, PML and MS: how to minimize 'one' while treating the 'other'.
Major EO, Douek DC, Frohman EM, Walsh DR.
Expert Rev Clin Immunol. 2013 Oct;9(10):887-90. doi: 10.1586/1744666X.2013.841559.

Journal of Immunology

Coadministration of Polyinosinic:Polycytidylic Acid and Immunostimulatory Complexes Modifies Antigen Processing in Dendritic Cell Subsets and Enhances HIV Gag-Specific T Cell Immunity.
Quinn KM, Yamamoto A, Costa A, Darrah PA, Lindsay RW, Hegde ST, Johnson TR, Flynn BJ, Loré K, Seder RA.
J Immunol. 2013 Nov 15;191(10):5085-96. doi: 10.4049/jimmunol.1301730. Epub 2013 Oct 2.

Vaccine

Safety and tolerability of a live oral Salmonella typhimurium vaccine candidate in SIV-infected nonhuman primates.
Ault A, Tennant SM, Gorres JP, Eckhaus M, Sandler NG, Roque A, Livio S, Bao S, Foulds KE, Kao SF, Roederer M, Schmidlein P, Boyd MA, Pasetti MF, Douek DC, Estes JD, Nabel GJ, Levine MM, Rao SS.
Vaccine. 2013 Oct 5. doi:pii: S0264-410X(13)01295-4. 10.1016/j.vaccine.2013.09.041.

New England Journal of Medicine

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine.
Hammer SM, Sobieszczyk ME, Janes H, Karuna ST, Mulligan MJ, Grove D, Koblin BA, Buchbinder SP, Keefer MC, Tomaras GD, Frahm N, Hural J, Anude C, Graham BS, Enama ME, Adams E, Dejesus E, Novak RM, Frank I, Bentley C, Ramirez S, Fu R, Koup RA, Mascola JR, Nabel GJ, Montefiori DC, Kublin J, McElrath MJ, Corey L, Gilbert PB; the HVTN 505 Study Team.
N Engl J Med. 2013 Oct 7

Proceedings of the National Academy of Sciences USA

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.
Zhu J, Wu X, Zhang B, McKee K, O'Dell S, Soto C, Zhou T, Casazza JP; NISC Comparative Sequencing Program, Mullikin JC, Kwong PD, Mascola JR, Shapiro L.
Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):E4088-97. doi: 10.1073/pnas.1306262110. Epub 2013 Oct 8.

Immunity

Systemic Effects of Inflammation on Health during Chronic HIV Infection.
Deeks SG, Tracy R, Douek DC.
Immunity. 2013 Oct 17;39(4):633-45. doi: 10.1016/j.immuni.2013.10.001.

September

Immunological Reviews

Advances in antiviral vaccine development.
Graham BS.
Immunol Rev. 2013 Sep;255(1):230-42. doi: 10.1111/imr.12098.

Nature Reviews Immunology

Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning.
Kwong PD, Mascola JR, Nabel GJ.
Nat Rev Immunol. 2013 Sep;13(9):693-701. doi: 10.1038/nri3516.

Current Opinion in HIV and AIDS

Elicitation of HIV-1-neutralizing antibodies against the CD4-binding site.
Georgiev IS, Gordon Joyce M, Zhou T, Kwong PD.
Curr Opin HIV AIDS. 2013 Sep;8(5):382-92. doi: 10.1097/COH.0b013e328363a90e.

Neurology

Risk factors for rare diseases can be risky to define: PML and natalizumab.
Major EO, Douek DC.
Neurology. 2013 Sep 3;81(10):858-9. doi: 10.1212/WNL.0b013e3182a352a6. Epub 2013 Aug 7.

Nature Protocols

Isolation of human monoclonal antibodies from peripheral blood B cells.
Huang J, Doria-Rose NA, Longo NS, Laub L, Lin CL, Turk E, Kang BH, Migueles SA, Bailer RT, Mascola JR, Connors M.
Nat Protoc. 2013 Oct;8(10):1907-15. doi: 10.1038/nprot.2013.117. Epub 2013 Sep 12.

European Journal of Immunology

Subtypes of type I IFN differentially enhance cytokine expression by sub-optimally stimulated CD4+ T cells.
Hillyer P, Raviv N, Gold DM, Dougherty D, Liu J, Johnson TR, Graham BS, Rabin RL.
Eur J Immunol. 2013 Sep 9. doi: 10.1002/eji.201243288. [Epub ahead of print]

Journal of Virology

Robust Neutralizing Antibodies Elicited by HIV-1 JRFL Envelope Glycoprotein Trimers in Non-human Primates.
Chakrabarti BK, Feng Y, Sharma SK, McKee K, Karlsson Hedestam GB, Labranche CC, Montefiore DC, Mascola JR, Wyatt RT.
J Virol. 2013 Sep 25. [Epub ahead of print]

Public Library of Science One

Plasma IgG to Linear Epitopes in the V2 and V3 Regions of HIV-1 gp120 Correlate with a Reduced Risk of Infection in the RV144 Vaccine Efficacy Trial.
Gottardo R, Bailer RT, Korber BT, Gnanakaran S, Phillips J, Shen X, Tomaras GD, Turk E, Imholte G, Eckler L, Wenschuh H, Zerweck J, Greene K, Gao H, Berman PW, Francis D, Sinangil F, Lee C, Nitayaphan S, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Tartaglia J, Robb ML, Michael NL, Kim JH, Zolla-Pazner S, Haynes BF, Mascola JR, Self S, Gilbert P, Montefiori DC.
PLoS One. 2013 Sep 26;8(9):e75665.

New England Journal of Medicine

More on JC viremia in natalizumab-treated patients with multiple sclerosis.
Major EO, Frohman E, Douek D.
N Engl J Med. 2013 Sep 26;369(13):1280. doi: 10.1056/NEJMc1308784. No abstract available.

August

Cytometry A

OMIP-019: Quantification of human γδT-cells, iNKT-cells, and hematopoietic precursors.
Mahnke YD, Beddall MH, Roederer M.
Cytometry A. 2013 Aug;83(8):676-8. doi: 10.1002/cyto.a.22326.

Journal of Infectious Diseases

Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers.
Chun TW, Shawn Justement J, Murray D, Kim CJ, Blazkova J, Hallahan CW, Benko E, Costiniuk CT, Kandel G, Ostrowski M, Kaul R, Moir S, Casazza JP, Koup RA, Kovacs C, Fauci AS.
J Infect Dis. 2013 Aug 1. [Epub ahead of print]

Immunity

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
Zhou T, Zhu J, Wu X, Moquin S, Zhang B, Acharya P, Georgiev IS, Altae-Tran HR, Chuang GY, Joyce MG, Do Kwon Y, Longo NS, Louder MK, Luongo T, McKee K, Schramm CA, Skinner J, Yang Y, Yang Z, Zhang Z, Zheng A, Bonsignori M, Haynes BF, Scheid JF, Nussenzweig MC, Simek M, Burton DR, Koff WC; NISC Comparative Sequencing Program, Mullikin JC, Connors M, Shapiro L, Nabel GJ, Mascola JR, Kwong PD.
Immunity. 2013 Aug 22;39(2):245-58. doi: 10.1016/j.immuni.2013.04.012. Epub 2013 Aug 1.

Science

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine.
Seder RA, Chang LJ, Enama ME, Zephir KL, Sarwar UN, Gordon IJ, Holman LA, James ER, Billingsley PF, Gunasekera A, Richman A, Chakravarty S, Manoj A, Velmurugan S, Li M, Ruben AJ, Li T, Eappen AG, Stafford RE, Plummer SH, Hendel CS, Novik L, Costner PJ, Mendoza FH, Saunders JG, Nason MC, Richardson JH, Murphy J, Davidson SA, Richie TL, Sedegah M, Sutamihardja A, Fahle GA, Lyke KE, Laurens MB, Roederer M, Tewari K, Epstein JE, Sim BK, Ledgerwood JE, Graham BS, Hoffman SL; the VRC 312 Study Team.
Science. 2013 Aug 8. [Epub ahead of print]

Nature Chemical Biology

Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies.
Amin MN, McLellan JS, Huang W, Orwenyo J, Burton DR, Koff WC, Kwong PD, Wang LX.
Nat Chem Biol. 2013 Aug;9(8):521-6. doi: 10.1038/nchembio.1288. Epub 2013 Jun 30.

July

Biostatistics

Mixture models for single-cell assays with applications to vaccine studies.
Finak G, McDavid A, Chattopadhyay P, Dominguez M, De Rosa S, Roederer M, Gottardo R.
Biostatistics. 2013 Jul 24. [Epub ahead of print]

Clinical and Experimental Immunology

Thymus transplantation restores the repertoires of forkhead box protein 3 (FoxP3)+ and FoxP3- T cells in complete DiGeorge anomaly.
Chinn IK, Milner JD, Scheinberg P, Douek DC, Markert ML.
Clin Exp Immunol. 2013 Jul;173(1):140-9. doi: 10.1111/cei.12088.

Clinical Immunology

CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.
Roux A, Mourin G, Fastenackels S, Almeida JR, Iglesias MC, Boyd A, Gostick E, Larsen M, Price DA, Sacre K, Douek DC, Autran B, Picard C, Miranda Sd, Sauce D, Stern M, Appay V.
Clin Immunol. 2013 Jul;148(1):16-26. doi: 10.1016/j.clim.2013.03.012. Epub 2013 Mar 29.

Immunological Reviews

HIV-1 neutralizing antibodies: understanding nature's pathways.
Mascola JR, Haynes BF.
Immunol Rev. 2013 Jul;254(1):225-44. doi: 10.1111/imr.12075.

Immunological Reviews

Immune activation and HIV persistence: implications for curative approaches to HIV infection.
Klatt NR, Chomont N, Douek DC, Deeks SG.
Immunol Rev. 2013 Jul;254(1):326-42. doi: 10.1111/imr.12065.

Journal of Acquired Immune Deficiency Syndromes

Neither Microbial Translocation Nor TLR Responsiveness Are Likely Explanations for Preexisting Immune Activation in Women Who Subsequently Acquired HIV in CAPRISA 004.
Naranbhai V, Samsunder N, Sandler NG, Roque A, Abdool Karim Q, Ndungʼu T, Carr WH, Altfeld M, Douek DC, Abdool Karim SS; for The CAPRISA 004 Trial Team.
J Acquir Immune Defic Syndr. 2013 Jul 1;63(3):294-298.

Journal of Immunology

Human Plasmacytoid Dendritic Cells Efficiently Capture HIV-1 Envelope Glycoproteins via CD4 for Antigen Presentation.
Sandgren KJ, Smed-Sörensen A, Forsell MN, Soldemo M, Adams WC, Liang F, Perbeck L, Koup RA, Wyatt RT, Karlsson Hedestam GB, Loré K.
J Immunol. 2013 Jul 1;191(1):60-9. doi: 10.4049/jimmunol.1202489. Epub 2013 May 31.

Journal of Virology

High production rates sustain in vivo levels of PD-1high SIV-specific CD8 T cells in the face of rapid clearance.
Petrovas C, Yamamoto T, Price DA, Rao SS, Klatt NR, Brenchley JM, Douek DC, Gostick E, Angermann BR, Grossman Z, Macallan DC, Meier-Schellersheim M, Koup RA.
J Virol. 2013 Jul 3. [Epub ahead of print]

Journal of Virology

Heavy chain-only IgG2b-llama antibody effects near-pan HIV-1 neutralization by recognizing a CD4-induced epitope that includes elements of both CD4- and co-receptor-binding sites.
Acharya P, Luongo T, Georgiev I, Matz J, Schmidt SD, Louder MK, Kessler P, Yang Y, McKee K, O'Dell S, Chen L, Baty D, Chames P, Martin L, Mascola JR, Kwong PD.
J Virol. 2013 Jul 10. [Epub ahead of print]

Journal of Virology

Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains.
Chuang GY, Acharya P, Schmidt SD, Yang Y, Louder MK, Zhou T, Kwon YD, Pancera M, Bailer RT, Doria-Rose NA, Nussenzweig MC, Mascola JR, Kwong PD, Georgiev IS.
J Virol. 2013 Jul 10. [Epub ahead of print]

Journal of Infectious Disease

Effect of Antiretroviral Therapy on HIV Reservoirs in Elite Controllers.
Chun TW, Justement JS, Murray D, Kim CJ, Blazkova J, Hallahan CW, Benko E, Costiniuk CT, Kandel G, Ostrowski M, Kaul R, Moir S, Casazza JP, Koup RA, Kovacs C, Fauci AS.
J Infect Dis. 2013 Jul 11. [Epub ahead of print]

June

The New England Journal of Medicine

JC viremia in natalizumab-treated patients with multiple sclerosis.
Major EO, Frohman E, Douek D.
N Engl J Med. 2013 Jun 6;368(23):2240-1. doi: 10.1056/NEJMc1214233.

Public Library of Science Pathogens

HIV-1 Vaccine-Induced T-Cell Reponses Cluster in Epitope Hotspots that Differ from Those Induced in Natural Infection with HIV-1.
Hertz T, Ahmed H, Friedrich DP, Casimiro DR, Self SG, Corey L, McElrath MJ, Buchbinder S, Horton H, Frahm N, Robertson MN, Graham BS, Gilbert P.
PLoS Pathog. 2013 Jun;9(6):e1003404. Epub 2013 Jun 20.

Molecular Therapy

Genetic Vaccine for Respiratory Syncytial Virus Provides Protection Without Disease Potentiation.
Johnson TR, Rangel D, Graham BS, Brough DE, Gall JG.
Mol Ther. 2013 Jun 10. doi: 10.1038/mt.2013.142.

Journal of Immunological Methods

A computational framework for the analysis of peptide microarray antibody binding data with application to HIV vaccine profiling.
Imholte GC, Sauteraud R, Korber B, Bailer RT, Turk ET, Shen X, Tomaras GD, Mascola JR, Koup RA, Montefiori DC, Gottardo R.
J Immunol Methods. 2013 Jun 13. doi:pii: S0022-1759(13)00173-7. 10.1016/j.jim.2013.06.001.

Nature

HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.
Cooper A, García M, Petrovas C, Yamamoto T, Koup RA, Nabel GJ.
Nature. 2013 Jun 20;498(7454):376-9. doi: 10.1038/nature12274. Epub 2013 Jun 5.

Science Translational Medicine

Getting to the heart of influenza.
Yewdell JW, Spiro DJ, Golding H, Quill H, Mittelman A, Nabel GJ.
Sci Transl Med. 2013 Jun 26;5(191):191ed8. doi: 10.1126/scitranslmed.3006735.

Journal of Medicinal Chemistry

Interfacial Cavity Filling To Optimize CD4-Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein.
Morellato-Castillo L, Acharya P, Combes O, Michiels J, Descours A, Ramos OH, Yang Y, Vanham G, Ariën KK, Kwong PD, Martin L, Kessler P.
J Med Chem. 2013 Jun 27;56(12):5033-47. doi: 10.1021/jm4002988. Epub 2013 Jun 11.

May

Cytometry A

OMIP-017: Human CD4(+) helper T-cell subsets including follicular helper cells.
Mahnke YD, Beddall MH, Roederer M.
Cytometry A. 2013 May;83(5):439-40. doi: 10.1002/cyto.a.22269. Epub 2013 Feb 28.

Public Library of Science Pathogens

Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient.
Yukl SA, Boritz E, Busch M, Bentsen C, Chun TW, Douek D, Eisele E, Haase A, Ho YC, Hütter G, Justement JS, Keating S, Lee TH, Li P, Murray D, Palmer S, Pilcher C, Pillai S, Price RW, Rothenberger M, Schacker T, Siliciano J, Siliciano R, Sinclair E, Strain M, Wong J, Richman D, Deeks SG.
PLoS Pathog. 2013 May;9(5):e1003347. doi: 10.1371/journal.ppat.1003347. Epub 2013 May 9.

Science

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization.
Georgiev IS, Doria-Rose NA, Zhou T, Kwon YD, Staupe RP, Moquin S, Chuang GY, Louder MK, Schmidt SD, Altae-Tran HR, Bailer RT, McKee K, Nason M, O'Dell S, Ofek G, Pancera M, Srivatsan S, Shapiro L, Connors M, Migueles SA, Morris L, Nishimura Y, Martin MA, Mascola JR, Kwong PD.
Science. 2013 May 10;340(6133):751-6. doi: 10.1126/science.1233989.

Journal of Immunology

Mutated PPP1R3B Is Recognized by T Cells Used To Treat a Melanoma Patient Who Experienced a Durable Complete Tumor Regression.
Lu YC, Yao X, Li YF, El-Gamil M, Dudley ME, Yang JC, Almeida JR, Douek DC, Samuels Y, Rosenberg SA, Robbins PF.
J Immunol. 2013 May 20. [Epub ahead of print]

Structure

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1.
Acharya P, Luongo TS, Louder MK, McKee K, Yang Y, Do Kwon Y, Mascola JR, Kessler P, Martin L, Kwong PD.
Structure. 2013 May 21. doi:pii: S0969-2126(13)00127-5. 10.1016/j.str.2013.04.015. [Epub ahead of print]

AIDS

Oral Serum-Derived Bovine Immunoglobulin Improves Duodenal Immune Reconstitution and Absorption Function in Patients with HIV Enteropathy.
Asmuth DM, Ma ZM, Albanese A, Sandler NG, Devaraj S, Knight TH, Flynn NM, Yotter T, Tsuchida E, Wu TT, Douek DC, Miller CJ.
AIDS. 2013 May 22. [Epub ahead of print]

Nature

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies.
Kanekiyo M, Wei CJ, Yassine HM, McTamney PM, Boyington JC, Whittle JR, Rao SS, Kong WP, Wang L, Nabel GJ.
Nature. 2013 May 22. doi: 10.1038/nature12202. [Epub ahead of print]

Journal of Infectious Diseases

DNA Priming Prior to Inactivated Influenza A(H5N1) Vaccination Expands the Antibody Epitope Repertoire and Increases Affinity Maturation in a Boost-Interval-Dependent Manner in Adults.
Khurana S, Wu J, Dimitrova M, King LR, Manischewitz J, Graham BS, Ledgerwood JE, Golding H.
J Infect Dis. 2013 May 23. [Epub ahead of print]

Journal of Infectious Diseases

Prime-Boost Interval Matters: A Randomized Phase 1 Study to Identify the Minimum Interval Necessary to Observe the H5 DNA Influenza Vaccine Priming Effect.
Ledgerwood JE, Zephir K, Hu Z, Wei CJ, Chang L, Enama ME, Hendel CS, Sitar S, Bailer RT, Koup RA, Mascola JR, Nabel GJ, Graham BS; the VRC 310 Study Team.
J Infect Dis. 2013 May 23. [Epub ahead of print]

Nature Structural & Molecular Biology

Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.
Pancera M, Shahzad-Ul-Hussan S, Doria-Rose NA, McLellan JS, Bailer RT, Dai K, Loesgen S, Louder MK, Staupe RP, Yang Y, Zhang B, Parks R, Eudailey J, Lloyd KE, Blinn J, Alam SM, Haynes BF, Amin MN, Wang LX, Burton DR, Koff WC, Nabel GJ, Mascola JR, Bewley CA, Kwong PD.
Nat Struct Mol Biol. 2013 May 26. doi: 10.1038/nsmb.2600. [Epub ahead of print]

Journal of Medicinal Chemistry

Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with the HIV-1 surface protein.
Morellato-Castillo L, Acharya P, Combes O, Michiels J, Descours A, Ramos OH, Yang Y, Vanham G, Ariën KK, Kwong PD, Martin L, Kessler P.
J Med Chem. 2013 May 27. [Epub ahead of print]

Science

Accelerating next-generation vaccine development for global disease prevention.
Koff WC, Burton DR, Johnson PR, Walker BD, King CR, Nabel GJ, Ahmed R, Bhan MK, Plotkin SA.
Science. 2013 May 31;340(6136):1232910. doi: 10.1126/science.1232910.

April

eLIFE

Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization.
Sun S, Xiang Y, Akahata W, Holdaway H, Pal P, Zhang X, Diamond MS, Nabel GJ, Rossmann MG.
Elife. 2013;2:e00435. doi: 10.7554/eLife.00435. Epub 2013 Apr 2.

Journal of Infectious Diseases

The Phenotype of the Cryptococcus-Specific CD4+ Memory T-Cell Response Is Associated With Disease Severity and Outcome in HIV-Associated Cryptococcal Meningitis.
Jarvis JN, Casazza JP, Stone HH, Meintjes G, Lawn SD, Levitz SM, Harrison TS, Koup RA.
J Infect Dis. 2013 Apr 3. [Epub ahead of print]

Nature

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.
Liao HX, Lynch R, Zhou T, Gao F, Alam SM, Boyd SD, Fire AZ, Roskin KM, Schramm CA, Zhang Z, Zhu J, Shapiro L; NISC Comparative Sequencing Program, Mullikin JC, Gnanakaran S, Hraber P, Wiehe K, Kelsoe G, Yang G, Xia SM, Montefiori DC, Parks R, Lloyd KE, Scearce RM, Soderberg KA, Cohen M, Kamanga G, Louder MK, Tran LM, Chen Y, Cai F, Chen S, Moquin S, Du X, Joyce MG, Srivatsan S, Zhang B, Zheng A, Shaw GM, Hahn BH, Kepler TB, Korber BT, Kwong PD, Mascola JR, Haynes BF.
Nature. 2013 Apr 25;496(7446):469-76. doi: 10.1038/nature12053. Epub 2013 Apr 3.

Public Library of Science One

DNA Vaccine Delivered by a Needle-Free Injection Device Improves Potency of Priming for Antibody and CD8+ T-Cell Responses after rAd5 Boost in a Randomized Clinical Trial.
Graham BS, Enama ME, Nason MC, Gordon IJ, Peel SA, Ledgerwood JE, Plummer SA, Mascola JR, Bailer RT, Roederer M, Koup RA, Nabel GJ; VRC 008 Study Team.
PLoS One. 2013;8(4):e59340. doi: 10.1371/journal.pone.0059340. Epub 2013 Apr 8.

Journal of Infectious Diseases

Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire.
Casazza JP, Bowman KA, Adzaku S, Smith EC, Enama ME, Bailer RT, Price DA, Gostick E, Gordon IJ, Ambrozak DR, Nason MC, Roederer M, Andrews CA, Maldarelli FM, Wiegand A, Kearney MF, Persaud D, Ziemniak C, Gottardo R, Ledgerwood JE, Graham BS, Koup RA; the VRC 101 Study Team.
J Infect Dis. 2013 Apr 11. [Epub ahead of print]

Journal of Virology

Suppressed Th17 Levels Correlate with Elevated PIAS3, SHP2, and SOCS3 Expression in CD4 T cells During Acute Simian Immunodeficiency Virus Infection.
Bixler SL, Sandler NG, Douek DC, Mattapallil JJ.
J Virol. 2013 Apr 17. [Epub ahead of print]

Vaccine

Strategic priorities for respiratory syncytial virus (RSV) vaccine development.
Anderson LJ, Dormitzer PR, Nokes DJ, Rappuoli R, Roca A, Graham BS.
Vaccine. 2013 Apr 18;31 Suppl 2:B209-15. doi: 10.1016/j.vaccine.2012.11.106.

Vaccine

The need and challenges for development of an Epstein-Barr virus vaccine.
Cohen JI, Mocarski ES, Raab-Traub N, Corey L, Nabel GJ.
Vaccine. 2013 Apr 18;31 Suppl 2:B194-6. doi: 10.1016/j.vaccine.2012.09.041.

Vaccine

Report of the Cent Gardes HIV Vaccine Conference: The B-cell response to HIV Part 2: Non-neutralizing antibodies: Fondation Mérieux Conference Center, Veyrier du Lac, France 5-7 November 2012.
Girard MP, Picot V, Longuet C, Nabel GJ.
Vaccine. 2013 Apr 18. doi:pii: S0264-410X(13)00258-2. 10.1016/j.vaccine.2013.02.067. [Epub ahead of print]

Vaccine

Accelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines.
Koff WC, Russell ND, Walport M, Feinberg MB, Shiver JW, Karim SA, Walker BD, McGlynn MG, Nweneka CV, Nabel GJ.
Vaccine. 2013 Apr 18;31 Suppl 2:B204-8. doi: 10.1016/j.vaccine.2012.10.115.

Journal of Virology

The Lack of Maturation of Ebola Virus-Infected Dendritic Cells Results from the Cooperative Effect of at Least Two Viral Domains.
Lubaki NM, Ilinykh P, Pietzsch C, Tigabu B, Freiberg AN, Koup RA, Bukreyev A.
J Virol. 2013 Apr 24. [Epub ahead of print]

Science

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody.
McLellan JS, Chen M, Leung S, Graepel KW, Du X, Yang Y, Zhou T, Baxa U, Yasuda E, Beaumont T, Kumar A, Modjarrad K, Zheng Z, Zhao M, Xia N, Kwong PD, Graham BS.
Science. 2013 Apr 25. [Epub ahead of print]

March

Journal of Acquired Immune Deficiency Syndromes

Neither microbial translocation nor TLR responsiveness are likely explanations for pre-existing immune activation in women who subsequently acquired HIV in CAPRISA004.
Naranbhai V, Samsunder N, Sandler NG, Roque A, Karim QA, Ndung'u T, Carr WH, Altfeld M, Douek DC, Abdool Karim SS; and The CAPRISA004 Trial Team.
J Acquir Immune Defic Syndr. 2013 Mar 11. [Epub ahead of print]

Journal of Infectious Diseases

Therapeutic Vaccination Expands and Improves the Function of the HIV-specific Memory T Cell Repertoire.
Casazza JP, Bowman K, Adzaku S, Smith EC, Enama ME, Bailer RT, Price DA, Gostick E, Gordon I, Ambrozak DR, Nason M, Roederer M, Andrews CA, Maldarelli FM, Wiegand A, Kearney MF, Persaud D, Ziemniak C, Gottardo R, Ledgerwood JE, Graham BS, Koup RA; The VRC 101 Study Team.
J Infect Dis. 2013 Mar 12. [Epub ahead of print]

Journal of Immunological Methods

Highly multiplexed quantitation of gene expression on single cells.
Dominguez MH, Chattopadhyay PK, Ma S, Lamoreaux L, McDavid A, Finak G, Gottardo R, Koup RA, Roederer M.
J Immunol Methods. 2013 Mar 13. doi:pii: S0022-1759(13)00090-2. 10.1016/j.jim.2013.03.002. [Epub ahead of print]

Vaccine

Report of the Cent Gardes HIV Vaccine Conference the B-cell Response to HIV. Part 1: Broadly Neutralizing Antibodies Fondation Mérieux Conference Center, Veyrier du Lac, France, 5-7 November 2012.
Girard MP, Picot V, Longuet C, Nabel GJ.
Vaccine. 2013 Mar 13. doi:pii: S0264-410X(13)00259-4. 10.1016/j.vaccine.2013.02.068. [Epub ahead of print]

Journal of Infectious Diseases

The Phenotype of the Cryptococcus-specific CD4 Memory T-cell Response is Associated with Disease Severity and Outcome in HIV-associated Cryptococcal Meningitis.
Jarvis JN, Casazza JP, Stone H, Meintjes G, Lawn SD, Levitz SM, Harrison TS, Koup RA.
J Infect Dis. 2013 Mar 14. [Epub ahead of print]

Journal of Immunology

Polyinosinic-Polycytidylic Acid Is the Most Effective TLR Adjuvant for SIV Gag Protein-Induced T Cell Responses In Nonhuman Primates.
Park H, Adamson L, Ha T, Mullen K, Hagen SI, Nogueron A, Sylwester AW, Axthelm MK, Legasse A, Piatak M Jr, Lifson JD, McElrath JM, Picker LJ, Seder RA.
J Immunol. 2013 Mar 15. [Epub ahead of print]

The Lancet Infectious Diseases

AS03-adjuvanted influenza vaccine in elderly people.
Ledgerwood JE.
Lancet Infect Dis. 2013 Mar 18. doi:pii: S1473-3099(13)70038-0. 10.1016/S1473-3099(13)70038-0. [Epub ahead of print] No abstract available.

Immunity

A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8(+) T Cells.
Ladell K, Hashimoto M, Iglesias MC, Wilmann PG, McLaren JE, Gras S, Chikata T, Kuse N, Fastenackels S, Gostick E, Bridgeman JS, Venturi V, Arkoub ZA, Agut H, van Bockel DJ, Almeida JR, Douek DC, Meyer L, Venet A, Takiguchi M, Rossjohn J, Price DA, Appay V.
Immunity. 2013 Mar 21;38(3):425-36. doi: 10.1016/j.immuni.2012.11.021.

Proceedings of the National Academy of Science USA

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.
Zhu J, Ofek G, Yang Y, Zhang B, Louder MK, Lu G, McKee K, Pancera M, Skinner J, Zhang Z, Parks R, Eudailey J, Lloyd KE, Blinn J, Alam SM, Haynes BF, Simek M, Burton DR, Koff WC; NISC Comparative Sequencing Program, Mullikin JC, Mascola JR, Shapiro L, Kwong PD.
Proc Natl Acad Sci U S A. 2013 Mar 27. [Epub ahead of print]

Cell

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization.
Klein F, Diskin R, Scheid JF, Gaebler C, Mouquet H, Georgiev IS, Pancera M, Zhou T, Incesu RB, Fu BZ, Gnanapragasam PN, Oliveira TY, Seaman MS, Kwong PD, Bjorkman PJ, Nussenzweig MC.
Cell. 2013 Mar 28;153(1):126-38. doi: 10.1016/j.cell.2013.03.018.

February

Journal of Virology

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.
Breed MW, Jordan AP, Aye PP, Lichtveld CF, Midkiff CC, Schiro FR, Haggarty BS, Sugimoto C, Alvarez X, Sandler NG, Douek DC, Kuroda MJ, Pahar B, Piatak M Jr, Lifson JD, Keele BF, Hoxie JA, Lackner AA.
J Virol. 2013 Feb;87(3):1528-43. doi: 10.1128/JVI.01928-12. Epub 2012 Nov 14.

Cytometry A

Quantifying spillover spreading for comparing instrument performance and aiding in multicolor panel design.
Nguyen R, Perfetto S, Mahnke YD, Chattopadhyay P, Roederer M.
Cytometry A. 2013 Mar;83(3):306-15. doi: 10.1002/cyto.a.22251. Epub 2013 Feb 6.

Journal of Immunology

Comparative Analysis of the Magnitude, Quality, Phenotype, and Protective Capacity of Simian Immunodeficiency Virus Gag-Specific CD8+ T Cells following Human-, Simian-, and Chimpanzee-Derived Recombinant Adenoviral Vector Immunization.
Quinn KM, Da Costa A, Yamamoto A, Berry D, Lindsay RW, Darrah PA, Wang L, Cheng C, Kong WP, Gall JG, Nicosia A, Folgori A, Colloca S, Cortese R, Gostick E, Price DA, Gomez CE, Esteban M, Wyatt LS, Moss B, Morgan C, Roederer M, Bailer RT, Nabel GJ, Koup RA, Seder RA.
J Immunol. 2013 Feb 6. [Epub ahead of print]

New England Journal of Medicine

Designing tomorrow's vaccines.
Nabel GJ.
N Engl J Med. 2013 Feb 7;368(6):551-60. doi: 10.1056/NEJMra1204186. Review. No abstract available.

Public Library of Science One

N332-Directed Broadly Neutralizing Antibodies Use Diverse Modes of HIV-1 Recognition: Inferences from Heavy-Light Chain Complementation of Function.
Pancera M, Yang Y, Louder MK, Gorman J, Lu G, McLellan JS, Stuckey J, Zhu J, Burton DR, Koff WC, Mascola JR, Kwong PD.
PLoS One. 2013;8(2):e55701. doi: 10.1371/journal.pone.0055701. Epub 2013 Feb 19.

January

Journal of Clinical Investigation

Superior T memory stem cell persistence supports long-lived T cell memory.
Lugli E, Dominguez MH, Gattinoni L, Chattopadhyay PK, Bolton DL, Song K, Klatt NR, Brenchley JM, Vaccari M, Gostick E, Price DA, Waldmann TA, Restifo NP, Franchini G, Roederer M.
J Clin Invest. 2013 Jan 2. doi:pii: 66327. 10.1172/JCI66327. [Epub ahead of print]

Virology

Impact of viral attachment factor expression on antibody-mediated neutralization of flaviviruses.
Obara CJ, Dowd KA, Ledgerwood JE, Pierson TC.
Virology. 2013 Jan 9. doi:pii: S0042-6822(12)00589-2. 10.1016/j.virol.2012.11.016. [Epub ahead of print]

Immunity

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2.
Liao HX, Bonsignori M, Alam SM, McLellan JS, Tomaras GD, Moody MA, Kozink DM, Hwang KK, Chen X, Tsao CY, Liu P, Lu X, Parks RJ, Montefiori DC, Ferrari G, Pollara J, Rao M, Peachman KK, Santra S, Letvin NL, Karasavvas N, Yang ZY, Dai K, Pancera M, Gorman J, Wiehe K, Nicely NI, Rerks-Ngarm S, Nitayaphan S, Kaewkungwal J, Pitisuttithum P, Tartaglia J, Sinangil F, Kim JH, Michael NL, Kepler TB, Kwong PD, Mascola JR, Nabel GJ, Pinter A, Zolla-Pazner S, Haynes BF.
Immunity. 2013 Jan 24;38(1):176-86. doi: 10.1016/j.immuni.2012.11.011. Epub 2013 Jan 11.

AIDS

Dendritic cell recruitment in response to skin antigen tests in HIV-1 infected individuals correlates with the level of T cell infiltration.
Liang F, Bond E, Sandgren KJ, Smed-Sörensen A, Rangaka MX, Lange C, Koup RA, McComsey GA, Lederman MM, Wilkinson RJ, Andersson J, Loré K.
AIDS. 2013 Jan 16. [Epub ahead of print]

Public Library of Science One

Analysis of V2 Antibody Responses Induced in Vaccinees in the ALVAC/AIDSVAX HIV-1 Vaccine Efficacy Trial.
Zolla-Pazner S, Decamp AC, Cardozo T, Karasavvas N, Gottardo R, Williams C, Morris DE, Tomaras G, Rao M, Billings E, Berman P, Shen X, Andrews C, O'Connell RJ, Ngauy V, Nitayaphan S, de Souza M, Korber B, Koup R, Bailer RT, Mascola JR, Pinter A, Montefiori D, Haynes BF, Robb ML, Rerks-Ngarm S, Michael NL, Gilbert PB, Kim JH.
PLoS One. 2013;8(1):e53629. doi: 10.1371/journal.pone.0053629. Epub 2013 Jan 17.

Bioinformatics

Data exploration, quality control and testing in single-cell qPCR-based gene expression experiments.
McDavid A, Finak G, Chattopadyay PK, Dominguez M, Lamoreaux L, Ma SS, Roederer M, Gottardo R.
Bioinformatics. 2013 Jan 21. [Epub ahead of print]

Archives of Virology

Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae.
Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Lofts LL, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST.
Arch Virol. 2013 Jan 29. [Epub ahead of print]

Last Updated January 17, 2014

Last Reviewed August 01, 2013