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Vaccine Research Center Journal Publications, 2014

The NIH Library provides information about online journal access.


Nature Structural & Molecular Biology
Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.
Bird GH, Irimia A, Ofek G, Kwong PD, Wilson IA, Walensky LD.
Nat Struct Mol Biol. 2014 Dec;21(12):1058-67.

Public Library of Science Pathogens
Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation.
Schuetz A, Deleage C, Sereti I, Rerknimitr R, Phanuphak N, Phuang-Ngern Y, Estes JD, Sandler NG, Sukhumvittaya S, Marovich M, Jongrakthaitae S, Akapirat S, Fletscher JL, Kroon E, Dewar R, Trichavaroj R, Chomchey N, Douek DC, O Connell RJ, Ngauy V, Robb ML, Phanuphak P, Michael NL, Excler JL, Kim JH, de Souza MS, Ananworanich J; RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups.
PLoS Pathog. 2014 Dec 11;10(12):e1004543.

Journal of Virology
Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites.
Acharya P, Luongo TS, Georgiev IS, Matz J, Schmidt SD, Louder MK, Kessler P, Yang Y, McKee K, O'Dell S, Chen L, Baty D, Chames P, Martin L, Mascola JR, Kwong PD.
J Virol. 2015 Jan 1;89(1):883-5. doi: 10.1128/JVI.02621-14. Epub 2014 Dec 16.

Journal of Virology
Correction for Chakrabarti et al., Robust Neutralizing Antibodies Elicited by HIV-1 JRFL Envelope Glycoprotein Trimers in Nonhuman Primates.
Chakrabarti BK, Feng Y, Sharma SK, McKee K, Karlsson Hedestam GB, LaBranche CC, Montefiori DC, Mascola JR, Wyatt RT.
J Virol. 2015 Jan 1;89(1):887. Epub 2014 Dec 16.

Journal of Virology
Improving Neutralization Potency and Breadth by Combining Broadly Reactive HIV-1 Antibodies Targeting Major Neutralization Epitopes.
Kong R, Louder MK, Wagh K, Bailer RT, deCamp A, Greene K, Gao H, Taft JD, Gazumyan A, Liu C, Nussenzweig MC, Korber B, Montefiori DC, Mascola JR.
J Virol. 2014 Dec 17.

Kernel-based logistic regression model for protein sequence without vectorialization.
Fong Y, Datta S, Georgiev IS, Kwong PD, Tomaras GD.
Biostatistics. 2014 Dec 22.

Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial.
Kibuuka H, Berkowitz NM, Millard M, Enama ME, Tindikahwa A, Sekiziyivu AB, Costner P, Sitar S, Glover D, Hu Z, Joshi G, Stanley D, Kunchai M, Eller LA, Bailer RT, Koup RA, Nabel GJ, Mascola JR, Sullivan NJ, Graham BS, Roederer M, Michael NL, Robb ML, Ledgerwood JE; the RV 247 Study Team.
Lancet. 2014 Dec 22.

Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262.
Kong L, Wilson IA, Kwong PD.
Proteins. 2014 Dec 26.


Jounal of Clinical Investigation
HIV-specific humoral responses benefit from stronger prime in phase Ib clinical trial.
Bart PA, Huang Y, Karuna ST, Chappuis S, Gaillard J, Kochar N, Shen X, Allen MA, Ding S, Hural J, Liao HX, Haynes BF, Graham BS, Gilbert PB, McElrath MJ, Montefiori DC, Tomaras GD, Pantaleo G, Frahm N.
J Clin Invest. 2014 Nov 3;124(11):4843-56. doi: 10.1172/JCI75894. Epub 2014 Oct 1.

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.
Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB 3rd, Kwong PD, Blanchard SC, Mothes W.
Science. 2014 Nov 7;346(6210):759-63.

Jounal of Immunology
Antibody to the gp120 V1/V2 Loops and CD4+ and CD8+ T Cell Responses in Protection from SIVmac251 Vaginal Acquisition and Persistent Viremia.
Gordon SN, Doster MN, Kines RC, Keele BF, Brocca-Cofano E, Guan Y, Pegu P, Liyanage NP, Vaccari M, Cuburu N, Buck CB, Ferrari G, Montefiori D, Piatak M Jr, Lifson JD, Xenophontos AM, Venzon D, Robert-Guroff M, Graham BS, Lowy DR, Schiller JT, Franchini G.
J Immunol. 2014 Nov 14.

The Role of Gr-1+ Cells and TNFα Signaling During Clostridium difficile Colitis in Mice.
McDermott AJ, Higdon KE, Muraglia R, Erb-Downward JR, Falkowski NR, McDonald RA, Young VB, Huffnagle GB.
Immunology. 2014 Nov 15.

Journal of Infectious Diseases
Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 Levels But Decreases Soluble Tissue Factor, Low-Density Lipoprotein (LDL) Cholesterol, and Oxidized LDL Cholesterol Levels in Individuals With Untreated HIV Infection.
Sandler NG, Zhang X, Bosch RJ, Funderburg NT, Choi AI, Robinson JK, Fine DM, Coombs RW, Jacobson JM, Landay AL, Douek DC, Tressler R, Read SW, Wilson CC, Deeks SG, Lederman MM, Gandhi RT.
J Infect Dis. 2014 Nov 15;210(10):1549-54.

Journal of Clinical Oncology
Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer.
Conlon KC, Lugli E, Welles HC, Rosenberg SA, Fojo AT, Morris JC, Fleisher TA, Dubois SP, Perera LP, Stewart DM, Goldman CK, Bryant BR, Decker JM, Chen J, Worthy TA, Figg WD Sr, Peer CJ, Sneller MC, Lane HC, Yovandich JL, Creekmore SP, Roederer M, Waldmann TA.
J Clin Oncol. 2014 Nov 17.

Nature Structural and Molecular Biology
Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies.
Bird GH, Irimia A, Ofek G, Kwong PD, Wilson IA, Walensky LD.
Nat Struct Mol Biol. 2014 Nov 24.

New England Journal of Medicine
Chimpanzee Adenovirus Vector Ebola Vaccine - Preliminary Report.
Ledgerwood JE, DeZure AD, Stanley DA, Novik L, Enama ME, Berkowitz NM, Hu Z, Joshi G, Ploquin A, Sitar S, Gordon IJ, Plummer SA, Holman LA, Hendel CS, Yamshchikov G, Roman F, Nicosia A, Colloca S, Cortese R, Bailer RT, Schwartz RM, Roederer M, Mascola JR, Koup RA, Sullivan NJ, Graham BS; the VRC 207 Study Team.
N Engl J Med. 2014 Nov 26.

AIDS Research and Human Retroviruses
HIV-1 Envelope Glycoprotein Trimer Immunogenicity Elicited in the Presence of Human CD4 Alters the Neutralization Profile.
Forsell MN, McKee K, Feng Y, Mascola JR, Wyatt RT.
AIDS Res Hum Retroviruses. 2014 Nov;30(11):1089-98.


Cytometry A
Q and B values are critical measurements required for inter-instrument standardization and development of multicolor flow cytometry staining panels.
Perfetto SP, Chattopadhyay PK, Wood J, Nguyen R, Ambrozak D, Hill JP, Roederer M.
Cytometry A. 2014 Dec;85(12):1037-48. doi: 10.1002/cyto.a.22579. Epub 2014 Oct 23.

Camouflage and Misdirection: The Full-On Assault of Ebola Virus Disease.
Misasi J, Sullivan NJ.
Cell. 2014 Oct 23;159(3):477-486. doi: 10.1016/j.cell.2014.10.006. Epub 2014 Oct 16. Review.

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD.
Nature. 2014 Oct 23;514(7523):455-61.

Journal of Immunology
Epitope specificity delimits the functional capabilities of vaccine-induced CD8 T cell populations.
Hill BJ, Darrah PA, Ende Z, Ambrozak DR, Quinn KM, Darko S, Gostick E, Wooldridge L, van den Berg HA, Venturi V, Larsen M, Davenport MP, Seder RA, Price DA, Douek DC.
J Immunol. 2014 Dec 1;193(11):5626-36. Epub 2014 Oct 27.


Journal of the American Medical Association Neurology
Relevance of CD34+ Cells as a Reservoir for JC Virus in Patients With Multiple Sclerosis-Reply.
Frohman EM, Douek D, Major EO.
JAMA Neurol. 2014 Sep 1;71(9):1192-3. doi: 10.1001/jamaneurol.2014.1858.

Proceedings of the National Academy of Sciences USA
Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals.
Hu H, Eller MA, Zafar S, Zhou Y, Gu M, Wei Z, Currier JR, Marovich MA, Kibuuka HN, Bailer RT, Koup RA, Robb ML, Michael NL, Kim JH, Ratto-Kim S.
Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13439-44. doi: 10.1073/pnas.1400446111. Epub 2014 Sep 2.

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface.
Huang J, Kang BH, Pancera M, Lee JH, Tong T, Feng Y, Georgiev IS, Chuang GY, Druz A, Doria-Rose NA, Laub L, Sliepen K, van Gils MJ, de la Peña AT, Derking R, Klasse PJ, Migueles SA, Bailer RT, Alam M, Pugach P, Haynes BF, Wyatt RT, Sanders RW, Binley JM, Ward AB, Mascola JR, Kwong PD, Connors M.
Nature. 2014 Sep 3. doi: 10.1038/nature13601.

Nature Reviews Immunology
Dendritic cell-targeted vaccines - hope or hype?
Kastenmüller W, Kastenmüller K, Kurts C, Seder RA.
Nat Rev Immunol. 2014 Oct;14(10):705-11. doi: 10.1038/nri3727. Epub 2014 Sep 5.

Nature Medicine
Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge.
Stanley DA, Honko AN, Asiedu C, Trefry JC, Lau-Kilby AW, Johnson JC, Hensley L, Ammendola V, Abbate A, Grazioli F, Foulds KE, Cheng C, Wang L, Donaldson MM, Colloca S, Folgori A, Roederer M, Nabel GJ, Mascola J, Nicosia A, Cortese R, Koup RA, Sullivan NJ.
Nat Med. 2014 Sep 7. doi: 10.1038/nm.3702.

Cell Host & Microbe
Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies.
Kepler TB, Liao HX, Alam SM, Bhaskarabhatla R, Zhang R, Yandava C, Stewart S, Anasti K, Kelsoe G, Parks R, Lloyd KE, Stolarchuk C, Pritchett J, Solomon E, Friberg E, Morris L, Karim SS, Cohen MS, Walter E, Moody MA, Wu X, Altae-Tran HR, Georgiev IS, Kwong PD, Boyd SD, Fire AZ, Mascola JR, Haynes BF.
Cell Host Microbe. 2014 Sep 10;16(3):304-13. doi: 10.1016/j.chom.2014.08.006.

Journal of Infectious Diseases
DNA Vaccines Encoding Ebolavirus and Marburgvirus Wild Type Glycoproteins are Safe and Immunogenic in a Phase I Clinical Trial.
Sarwar UN, Costner P, Enama ME, Berkowitz N, Hu Z, Hendel CS, Sitar S, Plummer S, Mulangu S, Bailer RT, Koup RA, Mascola JR, Nabel GJ, Sullivan NJ, Graham BS, Ledgerwood JE; the VRC 206 Study Team.
J Infect Dis. 2014 Sep 14. pii: jiu511.

Journal of Virology
Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies.
Bouvin-Pley M, Morgand M, Meyer L, Goujard C, Moreau A, Mouquet H, Nussenzweig M, Pace C, Ho D, Bjorkman PJ, Baty D, Chames P, Pancera M, Kwong PD, Poignard P, Barin F, Braibant M.
J Virol. 2014 Sep 17. pii: JVI.02083-14.

Tissue Myeloid Cells in SIV-Infected Primates Acquire Viral DNA through Phagocytosis of Infected T Cells.
Calantone N, Wu F, Klase Z, Deleage C, Perkins M, Matsuda K, Thompson EA, Ortiz AM, Vinton CL, Ourmanov I, Loré K, Douek DC, Estes JD, Hirsch VM, Brenchley JM.
Immunity. 2014 Sep 18;41(3):493-502. doi: 10.1016/j.immuni.2014.08.014.

Journal of Gerontology Biological Sciences and Medical Sciences
IFNγ-TNFα-IL2-MIP1α-CD107a+PRF1+ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans.
Ferrando-Martínez S, Ruiz-Mateos E, Casazza JP, de Pablo-Bernal RS, Dominguez-Molina B, Muñoz-Fernández MA, Delgado J, de la Rosa R, Solana R, Koup RA, Leal M.
J Gerontol A Biol Sci Med Sci. 2014 Sep 18. pii: glu171

Public Library of Science Neglected Tropical Diseases
A new approach for monitoring ebolavirus in wild great apes.
Reed PE, Mulangu S, Cameron KN, Ondzie AU, Joly D, Bermejo M, Rouquet P, Fabozzi G, Bailey M, Shen Z, Keele BF, Hahn B, Karesh WB, Sullivan NJ.
PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3143. doi: 10.1371/journal.pntd.0003143.

AIDS Research and Human Retroviruses
HIV-1 envelope glycoprotein trimer immunogenicity elicited in the presence of human CD4 alters the neutralization profile.
Forsell MN, McKee K, Feng Y, Mascola J, Wyatt RT.
AIDS Res Hum Retroviruses. 2014 Sep 22.

Journal of Virology
Hyperglycosylated stable core immunogens designed to present the CD4 binding site preferentially recognized by broadly neutralizing antibodies.
Ingale J, Tran K, Kong L, Dey B, McKee K, Schief W, Kwong PD, Mascola JR, Wyatt RT.
J Virol. 2014 Sep 24. pii: JVI.02614-14.

Filovirus RefSeq Entries: Evaluation and Selection of Filovirus Type Variants, Type Sequences, and Names.
Kuhn JH, Andersen KG, Bào Y, Bavari S, Becker S, Bennett RS, Bergman NH, Blinkova O, Bradfute S, Brister JR, Bukreyev A, Chandran K, Chepurnov AA, Davey RA, Dietzgen RG, Doggett NA, Dolnik O, Dye JM, Enterlein S, Fenimore PW, Formenty P, Freiberg AN, Garry RF, Garza NL, Gire SK, Gonzalez JP, Griffiths A, Happi CT, Hensley LE, Herbert AS, Hevey MC, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson JC, Johnson KM, Kindrachuk J, Klenk HD, Kobinger G, Kochel TJ, Lackemeyer MG, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Omilabu SA, Palacios G, Panchal RG, Park DJ, Patterson JL, Paweska JT, Peters CJ, Pettitt J, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Sabeti PC, Sealfon R, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST, Fackner DF, Shestopalov AM.
Viruses. 2014 Sep 26;6(9):3663-82. doi: 10.3390/v6093663.

Public Library of Science One
Homologous Boosting with Adenoviral Serotype 5 HIV Vaccine (rAd5) Vector Can Boost Antibody Responses despite Preexisting Vector-Specific Immunity in a Randomized Phase I Clinical Trial.
Sarwar UN, Novik L, Enama ME, Plummer SA, Koup RA, Nason MC, Bailer RT, McDermott AB, Roederer M, Mascola JR, Ledgerwood JE, Graham BS; VRC 015 study team.
PLoS One. 2014 Sep 29;9(9):e106240. doi: 10.1371/journal.pone.0106240.


BMC Immunology
Capturing needles in haystacks: a comparison of B-cell receptor sequencing methods.
Bashford-Rogers RJ, Palser AL, Idris SF, Carter L, Epstein M, Callard RE, Douek DC, Vassiliou GS, Follows GA, Hubank M, Kellam P.
BMC Immunol. 2014 Aug 5;15(1):29.

Journal of Clinical Investigation
FCGR2C polymorphisms associate with HIV-1 vaccine protection in RV144 trial.
Li SS, Gilbert PB, Tomaras GD, Kijak G, Ferrari G, Thomas R, Pyo CW, Zolla-Pazner S, Montefiori D, Liao HX, Nabel G, Pinter A, Evans DT, Gottardo R, Dai JY, Janes H, Morris D, Fong Y, Edlefsen PT, Li F, Frahm N, Alpert MD, Prentice H, Rerks-Ngarm S, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Robb ML, O'Connell RJ, Haynes BF, Michael NL, Kim JH, McElrath MJ, Geraghty DE.
J Clin Invest. 2014 Sep 2;124(9):3879-90. doi: 10.1172/JCI75539. Epub 2014 Aug 8.

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection.
Ko SY, Pegu A, Rudicell RS, Yang ZY, Joyce MG, Chen X, Wang K, Bao S, Kraemer TD, Rath T, Zeng M, Schmidt SD, Todd JP, Penzak SR, Saunders KO, Nason MC, Haase AT, Rao SS, Blumberg RS, Mascola JR, Nabel GJ.
Nature. 2014 Aug 13. doi: 10.1038/nature13612.

Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial.
Chang LJ, Dowd KA, Mendoza FH, Saunders JG, Sitar S, Plummer SH, Yamshchikov G, Sarwar UN, Hu Z, Enama ME, Bailer RT, Koup RA, Schwartz RM, Akahata W, Nabel GJ, Mascola JR, Pierson TC, Graham BS, Ledgerwood JE; the VRC 311 Study Team.
Lancet. 2014 Aug 14. pii: S0140-6736(14)61185-5. doi: 10.1016/S0140-6736(14)61185-5.

Journal of Virology
Impact of clade, geography and age of the epidemic on HIV-1 neutralization by antibodies.
Hraber P, Korber BT, Lapedes AS, Bailer RT, Seaman MS, Gao H, Greene KM, McCutchan F, Williamson C, Kim JH, Tovanabutra S, Hahn BH, Swanstrom R, Thomson MM, Gao F, Harris L, Giorgi E, Hengartner N, Bhattacharya T, Mascola JR, Montefiori DC.
J Virol. 2014 Aug 20. pii: JVI.01705-14.

Journal of Virology
Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo.
Rudicell RS, Kwon YD, Ko SY, Pegu A, Louder MK, Georgiev IS, Wu X, Zhu J, Boyington JC, Chen X, Shi W, Yang ZY, Doria-Rose NA, McKee K, O'Dell S, Schmidt SD, Chuang GY, Druz A, Soto C, Yang Y, Zhang B, Zhou T, Todd JP, Lloyd KE, Eudailey J, Roberts KE, Donald BR, Bailer RT, Ledgerwood J; NISC Comparative Sequencing Program, Mullikin JC, Shapiro L, Koup RA, Graham BS, Nason MC, Connors M, Haynes BF, Rao SS, Roederer M, Kwong PD, Mascola JR, Nabel GJ.
J Virol. 2014 Aug 20. pii: JVI.02213-14

Journal of Experimental Medicine
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.
Shingai M, Donau OK, Plishka RJ, Buckler-White A, Mascola JR, Nabel GJ, Nason MC, Montefiori D, Moldt B, Poignard P, Diskin R, Bjorkman PJ, Eckhaus MA, Klein F, Mouquet H, Cetrulo Lorenzi JC, Gazumyan A, Burton DR, Nussenzweig MC, Martin MA, Nishimura Y.
J Exp Med. 2014 Aug 25. pii: jem.20132494.

Journal of Virology
Structural Definition of an Antibody-Dependent Cellular Cytotoxicity (ADCC) Response Implicated in Reduced Risk for HIV-1 Infection.
Acharya P, Tolbert WD, Gohain N, Wu X, Yu L, Liu T, Huang W, Huang CC, Do Kwon Y, Louder RK, Luongo TS, McLellan JS, Pancera M, Yang Y, Zhang B, Flinko R, Foulke JS Jr, Sajadi MM, Kamin-Lewis R, Robinson JE, Martin L, Kwong PD, Guan Y, DeVico AL, Lewis GK, Pazgier M.
J Virol. 2014 Aug 27. pii: JVI.02194-14.

Public Library of Science Pathogens
HIV-1 Receptor Binding Site-Directed Antibodies Using a VH1-2 Gene Segment Orthologue Are Activated by Env Trimer Immunization.
Navis M, Tran K, Bale S, Phad GE, Guenaga J, Wilson R, Soldemo M, McKee K, Sundling C, Mascola J, Li Y, Wyatt RT, Karlsson Hedestam GB.
PLoS Pathog. 2014 Aug 28;10(8):e1004337. doi: 10.1371/journal.ppat.1004337. eCollection 2014 Aug.


Science Translational Medicine
Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor.
Pegu A, Yang ZY, Boyington JC, Wu L, Ko SY, Schmidt SD, McKee K, Kong WP, Shi W, Chen X, Todd JP, Letvin NL, Huang J, Nason MC, Hoxie JA, Kwong PD, Connors M, Rao SS, Mascola JR, Nabel GJ.
Sci Transl Med. 2014 Jul 2;6(243):243ra88. doi: 10.1126/scitranslmed.3008992.

Antimicrobial Agents and Chemotherapy
Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study.
Curreli F, Kwon YD, Zhang H, Yang Y, Scacalossi D, Kwong PD, Debnath AK.
Antimicrob Agents Chemother. 2014 Jul 7. pii: AAC.03339-14.

Public Library of Science Pathogens
T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection.
Buggert M, Tauriainen J, Yamamoto T, Frederiksen J, Ivarsson MA, Michaëlsson J, Lund O, Hejdeman B, Jansson M, Sönnerborg A, Koup RA, Betts MR, Karlsson AC.
PLoS Pathog. 2014 Jul 17;10(7):e1004251. doi: 10.1371/journal.ppat.1004251. eCollection 2014 Jul.

Cooperation of B Cell Lineages in Induction of HIV-1-Broadly Neutralizing Antibodies.
Gao F, Bonsignori M, Liao HX, Kumar A, Xia SM, Lu X, Cai F, Hwang KK, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF.
Cell. 2014 Jul 31;158(3):481-91. doi: 10.1016/j.cell.2014.06.022. Epub 2014 Jul 24.

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression.
Sandler NG, Bosinger SE, Estes JD, Zhu RT, Tharp GK, Boritz E, Levin D, Wijeyesinghe S, Makamdop KN, del Prete GQ, Hill BJ, Timmer JK, Reiss E, Yarden G, Darko S, Contijoch E, Todd JP, Silvestri G, Nason M, Norgren RB Jr, Keele BF, Rao S, Langer JA, Lifson JD, Schreiber G, Douek DC.
Nature. 2014 Jul 31;511(7511):601-5. doi: 10.1038/nature13554. Epub 2014 Jul 9.

Journal of Immunology
Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails To Protect against High-Dose Mycobacterium tuberculosis Challenge.
Darrah PA, Bolton DL, Lackner AA, Kaushal D, Aye PP, Mehra S, Blanchard JL, Didier PJ, Roy CJ, Rao SS, Hokey DA, Scanga CA, Sizemore DR, Sadoff JC, Roederer M, Seder RA.
J Immunol. 2014 Aug 15;193(4):1799-811. doi: 10.4049/jimmunol.1400676. Epub 2014 Jul 14.


Public Library of Science One
CD8+ TCR Transgenic Strains Expressing Public versus Private TCR Targeting the Respiratory Syncytial Virus KdM282-90 Epitope Demonstrate Similar Functional Profiles.
Bar-Haim E, Erez N, Malloy AM, Graham BS, Ruckwardt TJ.
PLoS One. 2014 Jun 4;9(6):e99249.

Public Library of Science Computational Biology
Quantification of HTLV-1 Clonality and TCR Diversity.
Laydon DJ, Melamed A, Sim A, Gillet NA, Sim K, Darko S, Kroll JS, Douek DC, Price DA, Bangham CR, Asquith B.
PLoS Comput Biol. 2014 Jun 19;10(6):e1003646.

AIDS Research and Human Retroviruses
The Immune Space: A Concept and Template for Rationalizing Vaccine Development.
Manrique A, Adams E, Barouch DH, Fast P, Graham BS, Kim JH, Kublin JG, McCluskey M, Pantaleo G, Robinson HL, Russell N, Snow W, Johnston MI.
AIDS Res Hum Retroviruses. 2014 Jun 26.


Journal of the American Medical Association Neurology
JC Virus in CD34+ and CD19+ Cells in Patients With Multiple Sclerosis Treated With Natalizumab.
Frohman EM, Monaco MC, Remington G, Ryschkewitsch C, Jensen PN, Johnson K, Perkins M, Liebner J, Greenberg B, Monson N, Frohman TC, Douek D, Major EO.
JAMA Neurol. 2014 May 1;71(5):596-602. doi: 10.1001/jamaneurol.2014.63. PMID:24664166

Journal of Allergy and Clinical Immunology
Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype.
Jing H, Zhang Q, Zhang Y, Hill BJ, Dove CG, Gelfand EW, Atkinson TP, Uzel G, Matthews HF, Mustillo PJ, Lewis DB, Kavadas FD, Hanson IC, Kumar AR, Geha RS, Douek DC, Holland SM, Freeman AF, Su HC.
J Allergy Clin Immunol. 2014 Jun;133(6):1667-75. doi: 10.1016/j.jaci.2014.03.025. Epub 2014 May 3.

Human Vaccines and Immunotherapeutics
A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 Vaccine: Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs.
Hokey DA, Wachholder R, Darrah PA, Bolton DL, Barouch DH, Hill K, Dheenadhayalan V, Schwander S, Godin CS, Douoguih M, Pau MG, Seder RA, Roederer M, Sadoff JC, Sizemore D.
Hum Vaccin Immunother. 2014 May 8;10(8).

Current Opinion in HIV and AIDS
T follicular helper cells and HIV/SIV-specific antibody responses.
Petrovas C, Koup RA.
Curr Opin HIV AIDS. 2014 May;9(3):235-41. doi: 10.1097/COH.0000000000000053. PMID:24670319

Journal of Infectious Diseases
Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 But Does Decrease Soluble Tissue Factor, LDL, and Oxidized LDL Levels in Untreated HIV Infection.
Sandler NG, Zhang X, Bosch RJ, Funderburg NT, Choi AI, Robinson JK, Fine DM, Coombs RW, Jacobson JM, Landay AL, Douek DC, Tressler R, Read SW, Wilson CC, Deeks SG, Lederman MM, Gandhi RT; on behalf of the AIDS Clinical Trials Group (ACTG) A5296 team.
J Infect Dis. 2014 May 26. pii: jiu305.


Journal of Virology
Pathogenic Features Associated with Increased Virulence upon Simian Immunodeficiency Virus Cross-Species Transmission from Natural Hosts.
Mandell DT, Kristoff J, Gaufin T, Gautam R, Ma D, Sandler N, Haret-Richter G, Xu C, Aamer H, Dufour J, Trichel A, Douek DC, Keele BF, Apetrei C, Pandrea I.
J Virol. 2014 Apr 2.

Public Library of Science Medicine
HIV monoclonal antibodies: a new opportunity to further reduce mother-to-child HIV transmission.
Voronin Y, Mofenson LM, Cunningham CK, Fowler MG, Kaleebu P, McFarland EJ, Safrit JT, Graham BS, Snow W.
PLoS Med. 2014 Apr 8;11(4):e1001616. doi: 10.1371/journal.pmed.1001616. eCollection 2014 Apr.

Journal of Virology
The mechanism and significance of cell type-dependent neutralization of flaviviruses.
Mukherjee S, Dowd KA, Manhart CJ, Ledgerwood JE, Durbin AP, Whitehead S, Pierson TC.
J Virol. 2014 Apr 16.

Journal of Virology
Structural Analysis of Respiratory Syncytial Virus Reveals the Position of M2-1 Between the Matrix Protein and the Ribonucleoprotein Complex.
Kiss G, Holl JM, Williams GM, Alonas E, Vanover D, Lifland AW, Gudheti M, Guerrero-Ferreira RC, Nair V, Yi H, Graham BS, Santangelo PJ, Wright ER.
J Virol. 2014 Apr 23.

Journal of Clinical Investigation
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
Bhadra R, Moretto MM, Castillo JC, Petrovas C, Ferrando-Martinez S, Shokal U, Leal M, Koup RA, Eleftherianos I, Khan IA.
J Clin Invest. 2014 Apr 24. pii: 70522. doi: 10.1172/JCI70522.

Nucleic Acids Research
NEP: web server for epitope prediction based on antibody neutralization of viral strains with diverse sequences.
Chuang GY, Liou D, Kwong PD, Georgiev IS.
Nucleic Acids Res. 2014 Apr 29.

Journal of Immunological Methods
Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials.
Sambor A, Garcia A, Berrong M, Pickeral J, Brown S, Rountree W, Sanchez A, Pollara J, Frahm N, Keinonen S, Kijak GH, Roederer M, Levine G, D'Souza MP, Jaimes M, Koup R, Denny T, Cox J, Ferrari G.
J Immunol Methods. 2014 Apr 29. pii: S0022-1759(14)00122-7. doi: 10.1016/j.jim.2014.04.005.



Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Doria-Rose NA, Schramm CA, Gorman J, Moore PL, Bhiman JN, Dekosky BJ, Ernandes MJ, Georgiev IS, Kim HJ, Pancera M, Staupe RP, Altae-Tran HR, Bailer RT, Crooks ET, Cupo A, Druz A, Garrett NJ, Hoi KH, Kong R, Louder MK, Longo NS, McKee K, Nonyane M, O'Dell S, Roark RS, Rudicell RS, Schmidt SD, Sheward DJ, Soto C, Wibmer CK, Yang Y, Zhang Z, Nisc Comparative Sequencing, Mullikin JC, Binley JM, Sanders RW, Wilson IA, Moore JP, Ward AB, Georgiou G, Williamson C, Abdool Karim SS, Morris L, Kwong PD, Shapiro L, Mascola JR.
Nature. 2014 Mar 2. doi: 10.1038/nature13036.

Journal of Clinical Investigation

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.
Bonsignori M, Wiehe K, Grimm SK, Lynch R, Yang G, Kozink DM, Perrin F, Cooper AJ, Hwang KK, Chen X, Liu M, McKee K, Parks RJ, Eudailey J, Wang M, Clowse M, Criscione-Schreiber LG, Moody MA, Ackerman ME, Boyd SD, Gao F, Kelsoe G, Verkoczy L, Tomaras GD, Liao HX, Kepler TB, Montefiori DC, Mascola JR, Haynes BF.
J Clin Invest. 2014 Apr 1;124(4):1835-43. doi: 10.1172/JCI73441. Epub 2014 Mar 10.

Public Library of Science One

Phase I Randomized Clinical Trial of VRC DNA and rAd5 HIV-1 Vaccine Delivery by Intramuscular (IM), Subcutaneous (SC) and Intradermal (ID) Administration (VRC 011).
Enama ME, Ledgerwood JE, Novik L, Nason MC, Gordon IJ, Holman L, Bailer RT, Roederer M, Koup RA, Mascola JR, Nabel GJ, Graham BS; VRC 011 Study Team.
PLoS One. 2014 Mar 12;9(3):e91366. doi: 10.1371/journal.pone.0091366. eCollection 2014.

Clinical and Vaccine Immunology

Adenovirus type 4 and type 7 vaccination or type 4 respiratory infection elicit minimal cross-reactive antibody to non-human adenovirus vaccine vectors.
Paris R, Kuschner RA, Binn L, Thomas SJ, Colloca S, Nicosia A, Cortese R, Bailer RT, Sullivan N, Koup RA.
Clin Vaccine Immunol. 2014 Mar 12.

Journal of Immunology

Single-Cell and Deep Sequencing of IgG-Switched Macaque B Cells Reveal a Diverse Ig Repertoire following Immunization.
Sundling C, Zhang Z, Phad GE, Sheng Z, Wang Y, Mascola JR, Li Y, Wyatt RT, Shapiro L, Karlsson Hedestam GB.
J Immunol. 2014 Apr 15;192(8):3637-44. doi: 10.4049/jimmunol.1303334. Epub 2014 Mar 12.

Cytometry A

International society for the advancement of cytometry cell sorter biosafety standards.
Holmes KL, Fontes B, Hogarth P, Konz R, Monard S, Pletcher CH Jr, Wadley RB, Schmid I, Perfetto SP.
Cytometry A. 2014 Mar 13. doi: 10.1002/cyto.a.22454.

Science Translational Medicine

Vaccine-Induced Env V1-V2 IgG3 Correlates with Lower HIV-1 Infection Risk and Declines Soon After Vaccination.
Yates NL, Liao HX, Fong Y, Decamp A, Vandergrift NA, Williams WT, Alam SM, Ferrari G, Yang ZY, Seaton KE, Berman PW, Alpert MD, Evans DT, O'Connell RJ, Francis D, Sinangil F, Lee C, Nitayaphan S, Rerks-Ngarm S, Kaewkungwal J, Pitisuttithum P, Tartaglia J, Pinter A, Zolla-Pazner S, Gilbert PB, Nabel GJ, Michael NL, Kim JH, Montefiori DC, Haynes BF, Tomaras GD.
Sci Transl Med. 2014 Mar 19;6(228):228ra39. doi: 10.1126/scitranslmed.3007730.

Journal of Infectious Diseases

Protecting the Family to Protect the Child: Vaccination Strategy Guided by RSV Transmission Dynamics.
Graham BS.
J Infect Dis. 2014 Mar 21.

Journal of the American Medical Association Neurology

JC Virus in CD34+ and CD19+ Cells in Patients With Multiple Sclerosis Treated With Natalizumab.
Frohman EM, Monaco MC, Remington G, Ryschkewitsch C, Jensen PN, Johnson K, Perkins M, Liebner J, Greenberg B, Monson N, Frohman TC, Douek D, Major EO.
JAMA Neurol. 2014 Mar 24. doi: 10.1001/jamaneurol.2014.63.

Journal of Clinical Investigation

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors.
Gros A, Robbins PF, Yao X, Li YF, Turcotte S, Tran E, Wunderlich JR, Mixon A, Farid S, Dudley ME, Hanada KI, Almeida JR, Darko S, Douek DC, Yang JC, Rosenberg SA.
J Clin Invest. 2014 Mar 25. pii: 73639. doi: 10.1172/JCI73639.


Public Library of Science One

Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection.
Zolla-Pazner S, Decamp A, Gilbert PB, Williams C, Yates NL, Williams WT, Howington R, Fong Y, Morris DE, Soderberg KA, Irene C, Reichman C, Pinter A, Parks R, Pitisuttithum P, Kaewkungwal J, Rerks-Ngarm S, Nitayaphan S, Andrews C, O'Connell RJ, Yang ZY, Nabel GJ, Kim JH, Michael NL, Montefiori DC, Liao HX, Haynes BF, Tomaras GD.
PLoS One. 2014 Feb 4;9(2):e87572.


Proof of principle for epitope-focused vaccine design.
Correia BE, Bates JT, Loomis RJ, Baneyx G, Carrico C, Jardine JG, Rupert P, Correnti C, Kalyuzhniy O, Vittal V, Connell MJ, Stevens E, Schroeter A, Chen M, Macpherson S, Serra AM, Adachi Y, Holmes MA, Li Y, Klevit RE, Graham BS, Wyatt RT, Baker D, Strong RK, Crowe JE, Johnson PR, Schief WR.
Nature. 2014 Feb 5. doi: 10.1038/nature12966.

Journal of Virology

Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy chain lineages.
Whittle JR, Wheatley AK, Wu L, Lingwood D, Kanekiyo M, Ma SS, Narpala SR, Yassine HM, Frank GM, Yewdell JW, Ledgerwood JE, Wei CJ, McDermott AB, Graham BS, Koup RA, Nabel GJ.
J Virol. 2014 Feb 5.

Accounts of Chemical Research

Structure-Based Design, Synthesis and Validation of CD4-Mimetic Small Molecule Inhibitors of HIV-1 Entry: Conversion of a Viral Entry Agonist to an Antagonist.
Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, Lalonde JM, Smith AB 3rd.
Acc Chem Res. 2014 Feb 6.

Journal of Infectious Diseases

Protecting the Family to Protect the Child: Vaccination Strategy Guided by RSV Transmission Dynamics.
Graham BS.
J Infect Dis. 2014 Feb 12.

Public Library of Science Pathogens

Quantitative and Qualitative Deficits in Neonatal Lung-Migratory Dendritic Cells Impact the Generation of the CD8+ T Cell Response.
Ruckwardt TJ, Malloy AM, Morabito KM, Graham BS.
PLoS Pathog. 2014 Feb 13;10(2):e1003934.


Journal of Immunology

Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline.
Georgiev IS, Rudicell RS, Saunders KO, Shi W, Kirys T, McKee K, O'Dell S, Chuang GY, Yang ZY, Ofek G, Connors M, Mascola JR, Nabel GJ, Kwong PD.
J Immunol. 2014 Feb 1;192(3):1100-6. doi: 10.4049/jimmunol.1302515. Epub 2014 Jan 3.

Journal of Virology

TLR-7/8 and 9 agonists cooperate to enhance HIV-1 envelope antibody responses in rhesus macaques.
Moody MA, Santra S, Vandergrift NA, Sutherland LL, Gurley TC, Drinker MS, Allen AA, Xia SM, Meyerhoff RR, Parks R, Lloyd KE, Easterhoff D, Alam SM, Liao HX, Ward BM, Ferrari G, Montefiori DC, Tomaras GD, Seder RA, Letvin NL, Haynes BF.
J Virol. 2014 Jan 3.

Journal of Allergy and Clinical Immunology

Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.
Yu X, Almeida J, Darko S, van der Burg M, Deravin SS, Malech H, Gennery A, Chinn I, Markert ML, Douek DC, Milner JD.
J Allergy Clin Immunol. 2014 Jan 7. pii: S0091-6749(13)01782-X. doi: 10.1016/j.jaci.2013.11.018.

European Journal of Immunology

Clonotype-specific avidity influences the dynamics and hierarchy of virus-specific regulatory and effector CD4+ T-cell responses.
Liu J, Cao S, Peppers G, Kim SH, Graham BS.
Eur J Immunol. 2014 Jan 13. doi: 10.1002/eji.201343766.


Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection.
Hraber P, Seaman MS, Bailer RT, Mascola JR, Montefiori DC, Korber BT.
AIDS. 2014 Jan 14;28(2):163-9.

Nature Immunology

Single-cell technologies for monitoring immune systems.
Chattopadhyay PK, Gierahn TM, Roederer M, Love JC.
Nat Immunol. 2014 Jan 21;15(2):128-35. doi: 10.1038/ni.2796.

Proceedings of the National Academy of Sciences USA

Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues.
Fletcher CV, Staskus K, Wietgrefe SW, Rothenberger M, Reilly C, Chipman JG, Beilman GJ, Khoruts A, Thorkelson A, Schmidt TE, Anderson J, Perkey K, Stevenson M, Perelson AS, Douek DC, Haase AT, Schacker TW.
Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2307-12. doi: 10.1073/pnas.1318249111. Epub 2014 Jan 27.

Public Library of Science One

Crystal structures of HIV-1 gp120 envelope glycoprotein in complex with NBD analogues that target the CD4 binding site.
Kwon YD, Lalonde JM, Yang Y, Elban MA, Sugawara A, Courter JR, Jones DM, Smith AB 3rd, Debnath AK, Kwong PD.
PLoS One. 2014 Jan 28;9(1):e85940. doi: 10.1371/journal.pone.0085940. eCollection 2014.

Public Library of Science Pathogens

Loss of circulating CD4 T cells with B-cell helper function during chronic HIV infection.
Boswell KL, Paris R, Boritz E, Ambrozak D, Yamamoto T, Darko S, Wloka K, Wheatley A, Narpala S, McDermott A, Roederer M, Haubrich R, Connors M, Ake J, Douek DC, Kim J, Petrovas C, Koup RA.
PLoS Pathog. 2014 Jan 30;10(1):e1003853. doi: 10.1371/journal.ppat.1003853. eCollection 2014 Jan.

Last Updated January 28, 2015