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2010 NIAID Year in Review

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International Research at NIAID

NIAID coordinates and supports collaborative, international research programs focusing on select infectious diseases of substantial health importance in developing countries.

In fiscal year (FY) 2010, NIAID did the following:

  • Funded 599 international projects (domestic awards with a foreign component and foreign awards) totaling approximately $503 million, with 61 percent of funding invested in international HIV/AIDS and AIDS-related research
  • Supported international research activities in 103 countries
    • The 10 foreign countries receiving the largest level of NIAID funding were, in alphabetical order: Australia, Canada, The Netherlands, Malawi, Peru, South Africa, Thailand, Uganda, United Kingdom, and Zimbabwe.
  • Supported more than 400 foreign scientists to train or work in the United States as part of the National Institutes of Health (NIH) Visiting Scientist Program
  • Posted full-time staff in China, India, Mali, Nigeria, South Africa, and Uganda
An image that depicts countries around the world receiving NIAID funding.  There is also a bar graph that depicts the increase in NIAID funding for international research from fiscal years 1980, 2000, and 2010.
Global Health Research at NIAID. Credit: NIAID
A pie chart that highlights NIAID international funding by region.  The pie slices represent regions of the world including Sub-Saharan Africa, Europe/Eurasia, East Asia Pacific, Americas and the Caribbean, South Central Asia, as well as Middle East and North Africa
NIAID international funding by region: FY 2010. Credit: NIAID
Region Percentage
Sub-Saharan Africa
37.2

Europe/Eurasia

26.7
East Asia/Pacific
15.8
Americas and the Caribbean
16.1
South/Central Asia
3.7
Middle East and North Africa
0.5
Total
100.0

International Efforts To Tackle Tuberculosis

Tuberculosis (TB) remains one of the major causes of disability and death worldwide. Each year, more than 9 million people around the world become sick with TB and nearly 1.7 million people die of TB-related causes. The recent emergence of drug-resistant TB poses a major global health threat.

NIAID has a long-standing effort to understand how TB causes disease. Examples of international NIAID activities in FY 2010 include the following:

China-U.S. Research To Eliminate Tuberculosis (CURE-TB)

The World Health Organization estimates that almost half of all people with drug-resistant TB in 2008 were in China and India, with each reporting approximately 100,000 new cases. To address this problem, NIAID and Chinese officials with the Henan Provincial Health Bureau launched the first study of the Sino-U.S. (Henan) Tuberculosis Prevention and Treatment Research Institute in Zhengzhou, China. The Institute will develop diagnostic tools, treatment options, and prevention methods for multidrug-resistant and extensively drug-resistant TB.

To commemorate the opening of the initial study at the Sino-U.S. (Henan) Tuberculosis Prevention and Treatment Research Institute, an NIAID delegation was joined by the U.S. Ambassador to China and representatives from other U.S. Department of Health and Human Services agencies, Henan Provincial Health Bureau, Henan Provincial Chest Hospital, and the general public.

A photograph of NIAID Deputy Director, Dr. Hugh Auchincloss, and Deputy Director of Intramural Research, Dr. Karyl Barron.
NIAID Principal Deputy Director Hugh Auchincloss, M.D., addresses the audience at the opening ceremony of the initial study of the Sino-U.S. (Henan) Tuberculosis Prevention and Treatment Research Institute, while Karyl Barron, M.D., Deputy Director of the NIAID Division of Intramural Research, looks on. Credit: U.S. Embassy in China

US-Southern Africa Forum on Tuberculosis Research

To help catalyze an expansion of collaborative TB and TB/HIV research in southern Africa, NIAID sponsored the US/Southern Africa Forum on Tuberculosis Research in FY 2010. The meeting was convened in South Africa and was co-hosted by NIAID, the South African Medical Research Council, and the Howard Hughes Medical Institute. The forum focused on TB research in the southern African region and on opportunities for further international TB research cooperation. A competitive small grant program designed to assist in the formation of research partnerships in the region was developed following the forum, and six grants were awarded.

Optimizing treatment of patients co-infected with HIV and TB

In resource-limited countries, individuals infected with both HIV and TB often seek treatment after HIV has already damaged their immune systems and patients frequently die during the first few months after beginning TB treatment. An NIAID-funded study sought to address the appropriate time to administer TB medications in HIV-infected individuals. The Cambodian Early Versus Late Introduction of Antiretroviral Drugs (CAMELIA) clinical trial showed that the survival of untreated HIV-infected adults, newly diagnosed with TB, could be prolonged by starting antiretroviral therapy two weeks after beginning TB treatment, rather than waiting the standard eight weeks.

International Efforts to Combat Malaria

Nearly one million people die of malaria every year, mostly infants, young children, and pregnant women, and most of them in Africa. Finding effective ways to control the disease is a high priority of NIAID.

International Centers of Excellence for Malaria Research (ICEMR)

In FY 2010, NIAID announced approximately $14 million in first-year funding to establish 10 new malaria research centers in regions where malaria is endemic, including parts of Africa, Asia, the Pacific Islands, and Latin America. The ICEMRs will generate knowledge, tools, and evidence-based strategies to control malaria. Teams of scientists involved in the ICEMR program will be conducting research in more than 20 countries.

New Malaria Drug Candidate

A chemical that rids mice of malaria-causing parasites after a single oral dose may eventually become a new malaria drug. The compound, NITD609, was identified by an international team of NIAID-funded extramural and intramural investigators following an analysis of over 12,000 chemicals using a robotic screening technique customized to detect compounds active against the most deadly malaria parasite.

This promising anti-malarial drug has a mode of action that differs from the current drugs used to treat malaria. In test tube experiments, NITD609 was effective against drug-resistant malaria strains. Typically, rodents infected with the mouse malaria die within a week, but a single large dose of NITD609 cured all five infected mice that received it.

Additional tests in animals are under way, and early-stage safety tests in humans are planned for the near future. NITD609 can be formulated as a tablet and manufactured in large quantities.

Reference: M Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT. Spiroindolones, a potent compound class for the treatment of malaria. Science 2010 Sep 3;329(5996):1175-80.

International Efforts to Support Research Administration

NIAID conducted training sessions on regional grants and contracts policy and management in Canada, China, and the United Kingdom. At these sessions, NIAID grantees were informed about policies aimed at reducing the risk of inappropriate use of NIH funds. Specific topics included:

  • Grants management policies
  • Contract requirements
  • Resources for managing an NIAID award
  • Preparing progress and financial status reports
  • Information for subcontractors
  • NIAID select agent policy
  • Financial system reviews
Region Percentage
Africa
2

North America

24
South East Asia
42
Europe
32
Total
100
A pie chart displaying the demographics of the attendees at the NIAID regional grants and contract policy training for foreign awardees.
Attendance at NIAID's Regional Grants and Contracts Policy Training for Foreign Awardees: FY 2010. Credit: NIAID

Learn more about NIAID’s role in global research.

Last Updated April 04, 2012

Last Reviewed August 03, 2011