The most effective treatment available for HIV/AIDS, combination antiretroviral drug therapy (ART), does not completely eradicate the virus from the body and cure the disease. Once treatment is stopped, levels of virus in the body rebound within weeks in most people. As a result, HIV-infected individuals must continuously take a combination of potentially toxic drugs to maintain their health quality.
As an intermediate goal to finding a cure, in FY 2011 NIAID solicited research proposals for Innovative Therapies to Control HIV Infection for collaborations between academia and the private sector that would explore and advance new strategies to control HIV for a prolonged period without ART. These strategies would delay or eliminate rebound of the virus when ART is interrupted, reduce exposure to drugs and the resulting adverse side effects, free infected individuals from the complexities of continuous drug taking, and decrease the potential for transmitting the virus to others.
Last Updated December 28, 2012