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Stavudine; Zerit®; D4T

D4T chemical structure

In-vitro Data
Cell Strain EC50 IC50 Units TI Reference
PBMC HIV-1(LAV) 0.0088 - µM - 1
MT-4 HIV-1(IIIB) 0.05 19 µM 380 2
PBMC(PHA STIM.) HIV-1(LAV) 0.009 70 µM 78000 3

Data in NIAID Chemical Database NIAID/DAIDS Searchable Chemical Database

Clinical Information Link Clinical Infomation at ACTIS

Links to Drug Resistance Databases
HIV Sequence Database Drug Resistance Data at International Medical Press HIV Data at Stanford

References

  1. LIN T.-S.; SCHINAZI R.F.; PRUSOFF W.H., POTENT AND SELECTIVE IN-VITRO ACTIVITY OF 3'-DEOXYTHYMIDIN-2'-ENE(3'-DEOXY-2',3'-DIDEHYDROTHYMIDINE) AGAINST HUMAN IMMUNODEFIENCY VIRUS. BIOCHEM PHAR 36(17):2713-2718 (1987).
  2. BALZARINI, J.; VAN AESCHOT, A.; HERDEWIJN, P.; DE CLERCQ, E., RAPID COMMUNICATIONS - 5-CHLORO-SUBSTITUTED DERIVATIVES OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYURIDINE, 3'-FLUORO-2',3'-DIDEOXYURIDINE AND 3'-AZIDO-2',3'-DIDEOXYURIDINE AS ANTI-HIV AGENTS. BIOCHEM PHARMACOL 38(6):869-874 (1989).
  3. CHU, C.K.; SCHINAZI, R.F.; ARNOLD, B.H.; CANNON, D.L.; DOBOSZEWSKI, B.; BHADTI, V.B.; GU, Z., COMPARATIVE ACTIVITY OF 2',3'-SATURATED AND UNSATURATED PYRIMIDINE AND PURINE NUCLEOSIDES AGAINST HIV-1 IN PERIPHERAL BLOOD MONONUCLEAR CELLS. BIOCHEM PHARMACOL 37(19):3543-3548 (1988).

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