Baicalin; TJN-151
 |
Baicalin is a flavonoid non-nucleoside reverse transcriptase inhibitor
(NNRTI), isolated from the traditional Chinese medicinal plant Scutellaria
Baicalensis Georgi (3). |
In-vitro Data
| Cell |
Strain |
EC50 * |
IC50 † |
Units |
TI ‡ |
Reference |
| CEM-SS |
HIV-1(RF) |
56 |
>717 |
µM |
>12.8 |
3 |
| H9 |
HIV-1(RF) |
330 |
>717 |
µM |
>2 |
3 |
| H9 |
HIV-1(IIIB) |
115 |
>717 |
µM |
>5 |
3 |
| H9 |
HIV-1(IIIB) |
112 |
72 |
µM |
<1 |
1 |
| PBMC |
HIV-1(MN) |
0.5 |
>10 |
µg/mL |
>20 |
2 |
| PBMC(HIV-1+ CLIN ISOL) |
HIV-1(CLIN ISOL) |
0.2 |
20 |
µg/mL |
100 |
2 |
* EC50 (also commonly referred to as ED50 or IC50) is the effective concentration
that inhibits 50% of viral production, 50% of viral infectivity, or 50% of the
virus-induced cytopathic effect.
† IC50 (also referred to as CC50, CD50; TC50,TD50 or cytotoxicity) is
the inhibitory concentration that reduces cellular growth or viability of uninfected
cells by 50%.
‡ TI (also known as SI or selectivity index) is the therapeutic index
which is equal to IC50/EC50.
| Data in NIAID Chemical Database |
 |
References
- HU, C.-Q.; CHEN, K.; SHI, Q.; KILKUSKIE, R.E.; CHENG, Y.-C.; LEE, K.-H.,
ANTI-AIDS AGENTS, 10. ACACETIN-7-O-b-D-GALACTOPYRANOSIDE,
AN ANTI-HIV PRINCIPLE FROM CHRYSANTHEMUM MORIFOLIUM AND A STRUCTURE-ACTIVITY
CORRELATION WITH SOME RELATED FLAVONOIDS. J NAT PROD 57(1):42-51(1994).
- KITAMURA, K.; HONDA, M.; YOSHIZAKI, H.; YAMAMOTO, S.; NAKANE, H.; FUKUSHIMA,
M.; ONO, K.; TOKUNAGA, T., BAICALIN, AN INHIBITOR OF HIV-1 PRODUCTION IN
VITRO. ANTIVIR RES 37(2):131-140(1998).
- LI, B.-Q.; FU, T.; YAN, Y.-D.; BAYLOR, N.W.; RUSCETTI, F.W.; KUNG, H.-F.,
INHIBITION OF HIV INFECTION BY BAICALIN - A FLAVONOID COMPOUND PURIFIED
FROM CHINESE HERBAL MEDICINE. CELL MOL BIOL RES 39(2):119-124(1993).
