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Indinavir; Crixivan®

Indinavir chemical structure

In-vitro Data
Cell Strain EC50 IC50 Units TI Reference
MT-4 HIV-1(IIIB) EC95=0.1* >400 µM - 1
PBMC HIV-1(112 PRIM ISOL) EC95=0.1* - µM - 1
*EC95 is the concentration of drug that inhibits p24 production in infected cells by 95%.

Data in NIAID Chemical Database NIAID/DAIDS Searchable Chemical Database

Clinical Information Link Clinical Infomation at ACTIS

Links to Drug Resistance Databases
HIV Sequence Database Drug Resistance Data at International Medical Press HIV Data at Stanford

References

  1. VACCA, J.P.; DORSEY, B.D.; SCHLEIF, W.A.; LEVIN, R.B.; MCDANIEL, S.L.; DARKE, P.L.; ZUGAY, J.; QUINTERO, J.C.; BLAHY, O.M.; ROTH, E.; SARDANA V.V.; SCHLABACH A.J.; GRAHAM P.I.; CONDRA J.H.; GOTLIB L.; ANDERSON, P.S.; EMINI, E.A.; HUFF, J.R.; ET.AL., L-735,524: AN ORALLY BIOAVAILABLE HIV-1 PROTEASE INHIBITOR. PROC NATL ACAD SCI 91(9):4096-4100 (1994).

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