NIAID HIV/OI Searchable Chemical Database
CD4-gp120 Interaction
CD4, a member of the IgG superfamily, is a cell surface receptor expressed on helper T lymphocytes, monocytes, B-lymphocytes and several other cells. In addition to being a receptor for HIV, CD4 participates in the recognition of foreign peptides bound to class II MHC complexes (1).
The virion surface envelope glycoprotein, gp120, consist of five variable domains (V1-V5) and five conserved domains (C1-C5).
References
- DAGLEISH, A.G.; BEVERLY, P.C.; CLAPHAM, P.R.; ET AL., THE CD4 (T4) ANTIGEN IS AN ESSENTIAL COMPONENT OF THE RECEPTOR FOR THE AIDS RETROVIRUS. NATURE 312:763-764 (1984).
- ARTHOS, J.; DEEN K.C.; CHAIKIN M.A.; ET AL., IDENTIFICATION OF THE RESIDUES IN HUMAN CD4 CRITICAL FOR THE BINDING OF HIV. CELL 57:469 (1989).
