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New: NIAID searchable chemical database is available!

Database for Anti-HIV Compounds

Introduction

Computerized databases containing chemical structures and biological data have been established at the Division of AIDS (DAIDS) NIAID to monitor developments in the chemotherapy of HIV and opportunistic infections (OI's) and to serve as an information source. Information is acquired by continuous surveillance of primary literature sources. The entire database, consisting of more than 80,000 compounds, is currently available on the Internet. The NIAID chemical database is searchable by name structure and a variety of quantitave data fields.

This web site is currently divided into six sections:

Anti-AIDS drugs are listed by class and connected to a second page containing the chemical structure, chemical names, the in-vitro activity against different strains in different cell lines and the cellular toxicity of each drug. In many cases, the second page will also contain a link to databases containing drug clinical information (courtesy of ACTIS: AIDS Clinical Trials Information Service) and drug resistance data (courtesy of International Medical Press or Los Alamos National Laboratory or Stanford HIV database). The clinical information and resistance links, where available, are located below the in-vitro data table and can be accessed by clicking either icon within that section.

Clinical Infomation at ACTIS

HIV Sequence Database Drug Resistance Data at the International Medical Press HIV Data at Stanford

Literature references are also provided so the user can obtain the original publications. This site is still under construction and any comments, suggestions, or offers of assistance will be greatly appreciated and can be sent to Dr. Mohamed Nasr (phone: 301-496-0636; e-mail: mn12p@nih.gov)

The information provided on this web site is intended for research purposes only and should not be used as the basis for any medical treatment or therapy. Inclusion in this sample portion of the database does not imply recognition by the NIH of a compound's anti-HIV activity or clinical utility. These entries were selected from a broader database of more than 10,000 compounds, and, therefore, may or may not have demonstrated anti-HIV activity.

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