NIAID HIV/OI Searchable Chemical Database

Protein Glycosylation

Certain viral proteins undergo glycosylation, which has been pursued as a target for possible intervention (1-2). Castanospermine, a naturally occurring alkaloid and inhibitor of glucosidase-I served as a lead compound for the development of analogs. N-Butyl deoxynojirimycin(butyl-DNJ) and 6-butyl-castanospermine represent analogs with more potent activity against HIV (3).

References

1. JOHNSON, V.A.; WALKER, B.D.; BARLOW, M.A.; PARADIS, T.J.; CHOU, T.C.; HIRSCH, M.S., SYNERGISTIC INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 AND TYPE 2 REPLICATION IN VITRO BY CASTANOSPERMINE AND 3'-AZIDO-3'-DEOXYTHYMIDINE. ANTIMICROB AGENTS CHEMOTHER 33:53-57 (1989).
2. RUPRECHT, R.M.; MULLANEY, S.; ANDERSEN, J.; BRONSON, R., IN VIVO ANALYSIS OF CASTANOSPERMINE, A CANDIDATE ANTIRETROVIRAL AGENT. J AIDS 2:149 (1989).
3. SUNKARA, P.S., TAYLOR, D., KANG, M., BOWLIN, T., LIU, P., TYMS, A., SJOERDSMA, A. ANTI-HIV ACTIVITY OF CASTANOSPERMINE ANALOGS. LANCET, 1989;1:1206 (1989).