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Leading research to understand, treat, and prevent infectious, immunologic, and allergic diseases
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The Laboratory of Bacteriology (LB) studies bacteria that cause important human infections, including Chlamydia, Coxiella, Francisella, Rickettsia, and Salmonella. In addition, LB conducts research with pathogens listed as serious or urgent threats in the National Action Plan for Combating Antibiotic-Resistant Bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Klebsiella pneumoniae. The ultimate goal of our research is to identify novel or improved strategies to control bacterial diseases, including development of diagnostics, vaccines, and therapeutics. LB maintains a flexible laboratory and theoretical infrastructure to permit analysis of bacterial pathogens of special interest.

See the National Action Plan for Combating Antiobiotic-Resistant Bacteria (PDF).

Sections and Units

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Major Areas of Research

  • Investigation of molecular and cellular mechanisms of host-pathogen interactions, with special attention to emerging and re-emerging pathogens
  • Host innate and adaptive immune responses to bacterial infection
  • Neutrophil biology and function
  • Bacterial immune evasion and virulence mechanisms
  • Bacterial biofilms
  • Systems biology-level approaches for virulence factor and vaccine target discovery
  • Pathogen-occupied vacuole maturation and trafficking, and manipulation of host cell signal transduction pathways

Last Updated June 30, 2015