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Laboratory of Allergic Diseases

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Dean D. Metcalfe, M.D., Chief

301-496-2165

dmetcalfe@niaid.nih.gov

The Laboratory of Allergic Diseases (LAD) conducts basic and clinical research on immunologic diseases with an emphasis on disorders of immediate hypersensitivity, which include the spectrum of classic allergic diseases. LAD is composed of an interactive group of Ph.D.s., M.D.s., research nurses, technicians, and administrative staff, who work in contemporary laboratories adjacent to NIAID's clinical facilities. Scientific personnel are engaged in basic and translational research aimed at elucidating events in mast-cell-dependent, IgE-mediated allergic inflammatory reactions, including anaphylaxis, eosinophilic gastrointestinal diseases, and systemic mast cell disorders. Studies are focused on the role of mast cells, basophils, eosinophils and T lymphocytes, and their cytokines, in these disorders.

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Research Objectives

  • Study the growth, differentiation, and activation of mast cells, basophils, and eosinophils
  • Elucidate signal transduction pathways in inflammation
  • Understand the biological manifestations of effector-cell activation in tissues.
  • Perform clinical/translational research directed at understanding the pathogenesis of allergic inflammation
  • Find novel immunomodulatory and anti-inflammatory approaches to the treatment of allergic and immunologic disorders

Last Updated May 09, 2013

Last Reviewed May 09, 2013