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Laboratory of Allergic Diseases

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Kelly D. Stone, M.D., Ph.D.

Photo of Kelly D. Stone

Director, Allergy and Immunology Clinical Fellowship Program
Deputy Chief, Laboratory of Allergic Diseases
Director, NIH Clinical Center Allergy and Immunology Consultation Service

Major Areas of Research

  • Clinical disorders of the immune system in children, including allergic diseases and immunodeficiency diseases
  • Atopic dermatitis and genetic disorders of allergic inflammation
  • Genetic disorders of mast-cell homeostasis and activation in children and adults
  • Graduate medical education in clinical immunology and allergy
 

Program Description

Dr. Stone is the program director of the Allergy and Immunology Clinical Training Program.

Dr. Stone serves as a principal investigator on two protocols to support laboratory interests in the genetics and mechanisms of allergic inflammation in atopic dermatitis, severe atopic diseases, genetic disorders with features of allergic inflammation, and immunodeficiency diseases. He serves as a staff clinician working closely with Dr. Joshua Milner and the Genetics and Pathophysiology of Allergy Section of the Laboratory of Allergic Diseases, with a major interest in the advancement of research and clinical care for children with atopic dermatitis and other allergic and immunologic diseases.

Kelly Stone and an NIAID research team have found that wet wrap therapy combined with education on long-term skin care can dramatically improve the lives of children with severe eczema.

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Biography

Dr. Stone received his M.D. and Ph.D. in molecular and cell biology from the University of Maryland; completed residency training in pediatrics at the Children’s National Medical Center in Washington, DC; and completed fellowship training in allergy and immunology at Children’s Hospital Boston. He served on the faculty in the department of pediatrics at Harvard Medical School and Children’s Hospital Boston and at Children’s National Medical Center and George Washington University. He joined the Laboratory of Allergic Diseases in 2007, where he serves as deputy chief; director of the National Institutes of Health (NIH) Clinical Center Allergy and Immunology Clinical Fellowship Program; and director of the NIH Clinical Center Allergy and Immunology Consultation Service.

Dr. Stone is a Fellow of the American Academy of Allergy, Asthma & Immunology and American Academy of Pediatrics and a member of the Clinical Immunology Society.

Selected Publications

Zhang Y, Yu X, Ichikawa M, Lyons JJ, Datta S, Lamborn IT, Jing H, Kim ES, Biancalana M, Wolfe LA, DiMaggio T, Matthews HF, Kranick SM, Stone KD, Holland SM, Reich DS, Hughes JD, Mehmet H, McElwee J, Freeman AF, Freeze HH, Su HC, Milner JD. Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment. J Allergy Clin Immunol. 2014 May;133(5):1400-9, 1409.e1-5.

Lyons JJ, Sun G, Stone KD, Nelson C, Wisch L, O'Brien M, Jones N, Lindsley A, Komarow HD, Bai Y, Scott LM, Cantave D, Maric I, Abonia JP, Rothenberg ME, Schwartz LB, Milner JD, Wilson TM. Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities. J Allergy Clin Immunol. 2014 May;133(5):1471-4.

Siegel AM, Stone KD, Cruse G, Lawrence MG, Olivera A, Jung MY, Barber JS, Freeman AF, Holland SM, O'Brien M, Jones N, Nelson CG, Wisch LB, Kong HH, Desai A, Farber O, Gilfillan AM, Rivera J, Milner JD. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol. 2013 Dec;132(6):1388-96.

Lawrence MG, Barber JS, Sokolic RA, Garabedian EK, Desai AN, O'Brien M, Jones N, Bali P, Hershfield MS, Stone KD, Candotti F, Milner JD. Elevated IgE and atopy in patients treated for early-onset ADA-SCID. J Allergy Clin Immunol. 2013 Dec;132(6):1444-6.

Ombrello MJ, Remmers EF, Sun G, Freeman AF, Datta S, Torabi-Parizi P, Subramanian N, Bunney TD, Baxendale RW, Martins MS, Romberg N, Komarow H, Aksentijevich I, Kim HS, Ho J, Cruse G, Jung MY, Gilfillan AM, Metcalfe DD, Nelson C, O'Brien M, Wisch L, Stone K, Douek DC, Gandhi C, Wanderer AA, Lee H, Nelson SF, Shianna KV, Cirulli ET, Goldstein DB, Long EO, Moir S, Meffre E, Holland SM, Kastner DL, Katan M, Hoffman HM, Milner JD. Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions. N Engl J Med. 2012 Jan 26;366(4):330-8.

Visit PubMed for a complete publication listing.

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Last Updated June 17, 2014