The Inflammation Immunobiology Section (IIS) explores the link between inflammation and infectious disease, with a focus on the inflammatory sequelae elicited by respiratory virus pathogens. Our laboratory utilizes molecular, cellular, bioinformatics, and in vivo approaches to elucidate novel responses and to gain insight into critical interactions.
As a major feature of these studies, our group developed the pneumonia virus of mice (PVM; family Paramyxoviridae) as a significant model of acute respiratory virus infection. In contrast to many human respiratory virus pathogens, PVM undergoes robust replication in the respiratory tracts of rodent species, and reproduces many clinical and pathologic features of severe human respiratory virus infection in inbred strains of mice. With this model, our group is pursuing studies aimed at elucidating novel inflammatory pathways and original immunomodulatory therapies.
Related to these studies is our mainstay, the eosinophil, an enigmatic leukocyte whose role in innate immunity has recently undergone dramatic reconsideration. Eosinophils are best known for their contributions to the functional pathophysiology of allergic asthma; however, evolution tells us that the ability to induce pathology cannot be a raison d’être for any existing cell lineage. Several distinct lines of evidence have led us to consider the unrecognized beneficial impact provided by eosinophils in this setting, notably via their interactions with respiratory virus pathogens.
Dr. Rosenberg was awarded both M.D. and Ph.D. degrees from the Medical Scientist Training Program (MSTP) at The Rockefeller University / Cornell University Medical College (1984, 1985). Following postdoctoral research at Harvard University, she joined the National Institutes of Health in 1991, was granted tenure in 1998, and became a Section Chief in 2002.
L-R, front: Kimberly Dyer, Helene Rosenberg, Caroline PercopoL-R, back: Tyler Rice, Todd Brenner, Derek Barisas
Yamada KJ, Barker T, Dyer KD, Rice TA, Percopo CM, Garcia-Crespo KE, Cho S, Lee JJ, Druey KM, Rosenberg HF. Eosinophil-associated Ribonuclease 11 is a Macrophage Chemoattractant. J Biol Chem. 2015 290(14):8863-75.
Percopo CM, Dyer KD, Garcia-Crespo KE, Gabryszewski SJ, Shaffer AL 3rd, Domachowske JB, Rosenberg HF. B cells are not essential for Lactobacillus-mediated protection against lethal pneumovirus infection. J Immunol. 2014 Jun 1;192(11):5265-72.
Kumar RK, Foster PS, Rosenberg HF. Respiratory viral infection, epithelial cytokines and innate lymphoid cells in asthma exacerbations. J. Leukocyte Biol. 2014 Sep;96(3):391-396.
Percopo CM, Dyer KD, Ochkur SI, Luo JL, Fischer ER, Lee NA, Lee JJ, Domachowske JB, Rosenberg HF. Activated mouse eosinophils protect against lethal respiratory virus infection. Blood. 2014 Jan 30;123(5):743-52.
Glineur SF, Renshaw RW, Percopo CM, Dyer KD, Dubovi EJ, Domachowske JB, Rosenberg HF. Novel pneumoviruses (PnVs): evolution and inflammatory pathology. Virology. 2013 Sep 1;443(2):257-64.
Rosenberg HF, Dyer KD, Foster PS. Eosinophils: changing perspectives in health and disease. Nat Rev Immunol. 2013. Jan;13(1):9-22.
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Last Updated September 14, 2015