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Laboratory of Cellular and Molecular Immunology

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Ronald H. Schwartz, M.D., Ph.D., Chief

301-496-1257
rschwartz@niaid.nih.gov

Major Areas of Research

  • Role of the Notch protein in lineage commitment in the thymus and periphery
  • Role of danger, the tissues, and co-stimulatory signals in T-cell activation, tolerance, and class commitment
  • Molecular events involved in gene activation following T-cell receptor ligation
  • Molecular regulation of transcription of the interleukin 2 gene
  • Molecular and cellular aspects of both T-cell clonal anergy and adaptive tolerance
 

Program Description

Scientists in the Laboratory of Cellular and Molecular Immunology (LCMI) study the development, activation, tolerance, memory, and differentiation of thymus-derived (T) lymphocytes.

The laboratory offers educational training in immunology through summer tutorials and weekly journal and data clubs. In addition, there is research training in techniques such as flow cytometry, signal transduction biochemistry, fluorescence microscopy, and lymphocyte cell culture. All research is carried out using mouse models.

LCMI Chief Ronald H. Schwartz, M.D., Ph.D., discovered the phenomenon of T-cell anergy in immune response. Read more about T cells and anergy in Immunity: Natural and Acquired.

Sections and Units

T-Cell Activation Section

Ronald H. Schwartz, M.D., Ph.D.

T-Cell Development Section

B. J. Fowlkes, Ph.D.

Last Updated February 01, 2013