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Labs at NIAID

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The Laboratory of Human Bacterial Pathogenesis (LHBP) studies the molecular basis of human bacterial pathogenesis in its broadest sense. Research projects currently focus on Staphylococcus-host interactions, with special emphasis on the virulence mechanisms of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA).

LHBP scientists study mechanisms of staphylococcal virulence, innate immune response to pathogenic bacteria, and the role of neutrophils in host defense. In addition, mechanisms of immune evasion, such as the formation of biofilms, are a major area of investigation. Genome-wide strategies are used, such as high-throughput DNA sequencing and expression-array analysis.

Sections and Units

  • Pathogen-Host Cell Biology Section

  • Frank R. DeLeo, Ph.D.

  • Pathogen Molecular Genetics Section

  • Michael Otto, Ph.D.

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Research Objectives

  • Understand the fundamental molecular mechanisms of bacterial pathogen-host interactions.
  • Develop new or improved strategies to control bacterial infections.
  • Identify host genetic factors influencing disease character.
  • Define the cell biology of pathogen-host interactions.

Last Updated September 04, 2013