Laboratory of Immunology

Program Description

Work in the Integrative Immunobiology Unit is interested in how gene expression is orchestrated as cells differentiate from stem cells into effector cells in the immune system. In particular, his laboratory will study how these systems are controlled by the endogenous RNA interference machinery (e.g., microribonucleoprotein silencing complexes).

Biography

Dr. Muljo joined the Laboratory of Immunology (LI) in July 2008 to head the Integrative Immunobiology Unit. He earned his Ph.D. from the Graduate Program in Immunology at The Johns Hopkins University School of Medicine. Part of his dissertation work was performed at the department of molecular and cell biology in the division of immunology and pathogenesis, University of California, Berkeley. This was followed by a postdoctoral fellowship at the Immune Disease Institute (formerly the Center for Blood Research), Harvard Medical School.

Special Interest Groups

• Immunology
• Systems biology
• Genetics
• Proteomics
• Stem cell
• RNA
• Transcription factors

Research Group

Thelma Escobar, Graduate Partnerships Program student
Cuong Nguyen, Ph.D., visiting postdoctoral fellow
Joan Yuan, Ph.D., postdoctoral fellow
Brenna Brady, postdoctoral fellow
Patrick Burr, contractor
Gokhul Kilaru, contractor
Xiuhuai Liu, Ph.D., biologist

Left to right: Stefan Muljo, Ph.D.; Rami Zahr, contractor; Hunter Oliver-Allen, post-baccalaureate; Thelma Escobar, Graduate Partnerships Program student; Andrew Avery, summer intern; Cuong Nguyen, Ph.D., visiting postdoctoral fellow.

 

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Selected Publications

Yuan J, Nguyen CK, Liu X, Kanellopoulou C, Muljo SA. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science. 2012 Mar 9;335(6073):1195-200.

Visit PubMed for a complete publication listing.

Predoctoral Fellowship Opportunity

Joint doctoral studentship positions are open in the Integrative Immunobiology Unit and the Copley laboratory or Oreste Acuto’s laboratory at Oxford University, United Kingdom, as part of the NIH-OxCam Partnership Program.

Specifically, we have the following proposed collaborations that qualify for the NIH-Oxford University Scholar in Biomedical Research Program, NIH-Marshall Scholar Program, NIH-Rhodes Scholar Program, or NIH-Wellcome Trust Program:

• Systematic Modeling of Genetic Regulatory Networks
• Proteomic Identification of IncRNA-Binding Proteins and Other Ribonucleoprotein Complexes
• High-Throughput Identification of MicroRNA Targets in T Lymphocytes

For instructions on how to apply for the program, see Graduate Partnerships Program.