Read how NIAID scientists identified the genetic mutation that causes ‘XMEN’ disease.
Michael J. Lenardo, M.D.Building 10, Room 11N24610 Center DriveBethesda, MD 20892-1892Phone: 301-496-6754Fax: email@example.com
Our laboratory investigates the molecular regulation of T lymphocytes, particularly as it relates to immunological tolerance, apoptosis, and autoimmune diseases such as multiple sclerosis, type 1 diabetes mellitus, and similar diseases. We use both molecular biology and cellular immunology techniques to pursue these investigations, with a focus on programs of cell death and survival including apoptosis, autophagy, and necrosis mechanisms. Our goal is to understand the pathogenesis of autoimmunity from the vantage point of T-cell regulation as well as to develop novel means of diagnosis and immunomodulation of these diseases. Specifically, we are attempting to pioneer a means of antigen-specific induction of apoptosis of pathogenic T cells as a means of treating autoimmune disease. We have also undertaken the investigation of how HIV causes the death of CD4 T lymphocytes. Such studies could lead to a better understanding of viral pathogenesis as well as the development of new treatments for, or vaccines against, AIDS.
Front row (on the floor) from right: Fengyi Wan, Pushpa Pandiyan, Bernice Lo, Sophia Koessel, Benjamin Chaigne-Delalande
2nd row (sitting on the divan) from right: Maria G. Hessie, Feng-Yen Li, Nicole Yung, Angela Beckon, Carol Trageser, Zhihua Liu, Ping Jiang
3rd row (standing) from right: Mike Lenardo, Monika Jung, Hossam Ashour, Wei Lu, Andy Johnson, Tony Barnitz, Jae Won Lee, Andy Snow, Lixin Zheng
(View list in PubMed.)
Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, Cohen JI, Uzel G, Su HC, Lenardo MJ. Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature. 2011 Jul 27;475(7357):471-6.
Pandiyan P, Conti HR, Zheng L, Peterson AC, Mathern DR, Hernández-Santos N, Edgerton M, Gaffen SL, Lenardo MJ. CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity. 2011 Mar 25;34(3):422-34.
Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. 2010 Jun 17;465(7300):942-6.
Snow AL, Pandiyan P, Zheng L, Krummey SM, Lenardo MJ. The power and the promise of restimulation-induced cell death in human immune diseases. Immunol Rev. 2010 Jul;236:68-82.
Freundt EC, Yu L, Goldsmith CS, Welsh S, Cheng A, Yount B, Liu W, Frieman MB, Buchholz UJ, Screaton GR, Lippincott-Schwartz J, Zaki SR, Xu XN, Baric RS, Subbarao K, Lenardo MJ. The open reading frame 3a protein of severe acute respiratory syndrome-associated-coronavirus promotes membrane rearrangement and cell death. J Virol. 2010 Jan;84(2):1097-109.
Snow AL, Marsh RA, Krummey SM, Roehrs P, Young LR, Zhang K, van Hoff J, Dhar D, Nichols KE, Filipovich AH, Su HC, Bleesing JJ, Lenardo MJ. Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. J Clin Invest. 2009 Oct;119(10):2976-89.
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Last Updated March 27, 2013