Chemokines and their receptors are proteins important for leukocyte trafficking, are critical in immune responses and inflammation, and are emerging therapeutic targets in HIV and a variety of immune-mediated diseases.
Recently, members of the Inflammation Biology Section have been using the chemokine system to investigate the activities of human T-cell subsets and the differentiation of memory T cells, including the newly recognized Th17 cells; to understand cellular and molecular mechanisms in medically relevant models of inflammatory tissue injury, including models of Th17-cell mediated disease; and to develop new tools for clinical imaging in cancer and inflammation.
Dr. Farber obtained his M.D. from The Johns Hopkins University, where he did additional clinical training in internal medicine and infectious diseases. Dr. Farber's postdoctoral training in bench research was both at the National Institutes of Health and at Johns Hopkins. Dr. Farber joined the NIAID Laboratory of Clinical Investigation in 1993, became a senior investigator in 2000, and moved to the Laboratory of Molecular Immunology at its inception in 2004.
Chang Hoon Lee, Ph.D.
I obtained my Ph.D. in immunology from the State University of New York at Buffalo. Currently, I am using the chemokine system to understand the roles of highly differentiated CD4+ memory cells and how populations of these cells are produced and maintained.
Satya P. Singh, Ph.D.
I obtained my Ph.D. in life sciences from Jawaharlal Nehru University, New Delhi, India. My work focuses on using the chemokine system to understand the genetic mechanisms that drive the differentiation of human Th17 cells.
Tej Pratap Singh, Ph.D.
Hsinyi (Steve) Tsang, Ph.D.
I received my Ph.D. in bioinformatics from the Johns Hopkins University. I support projects in the laboratory by performing in-depth and downstream analyses of large data sets in order to identify candidate molecules for experimental investigations.
Xin Xu, M.D, Ph.D.
I received my M.D. from China Medical University, Shenyang, Liaoning, P. R. China, and my Ph.D. in medical science from Osaka University, Japan. I am currently focused on using the chemokine system to understand mechanisms of antibacterial host defense and toxin-induced acute tissue injury in mouse models of lung disease.
Howard H. Zhang, Ph.D.
I obtained my Ph.D. in immunology from Mississippi State University. In addition to my own studies focusing on chemokine receptors on human T cell subsets, I contribute to many of the laboratory's projects, providing support and advice in the areas of cellular immunology and protein chemistry.
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Weiss ID, Jacobson O, Kiesewetter DO, Jacobus JP, Szajek LP, Chen X, Farber JM. Positron emission tomography imaging of tumors expressing the human chemokine receptor CXCR4 in mice with the use of Cu-AMD3100. Mol Imaging Biol. 2012 Feb;14(1):106-14.
Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM. CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response. J Immunol. 2010 Dec 1;185(11):6646-63.
Singh SP, de Camargo MM, Zhang HH, Foley JF, Hedrick MN, Farber JM. Changes in histone acetylation and methylation that are important for persistent but not transient expression of CCR4 in human CD4+ T cells. Eur J Immunol. 2010 Nov;40(11):3183-97.
Foley JF, Singh SP, Cantu M, Chen L, Zhang HH, Ferber JM. Differentiation of human T cells alters their repertoire of G protein alpha-subunits. J Biol Chem. 2010 Nov 12;285(46):35537-50.
Hedrick MN, Lonsdorf AS, Hwang ST, Farber JB. CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. J Clin Invest. 2009 Feb 15;119(8):2317-29.
Singh SP, Zhang HH, Foley JF, Hedrick MN, Farber JM. Human T cells that are able to produce IL-17 express the chemokine receptor CCR6. J Immunol. 2008 Jan 1;180(1):214-21.
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Last Updated March 29, 2013