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Laboratory of  Molecular Immunology 

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Philip M. Murphy, M.D., Chief

301-496-8616

pmurphy@niaid.nih.gov

The Laboratory of Molecular Immunology (LMI) studies innate and adaptive immune system function in health and disease and is especially interested in delineating mechanisms that control specific leukocyte movement. A major focus at the molecular level is the chemokines and other chemoattractants and their G protein-coupled receptors. LMI scientists also pursue studies of mucosal immunology in the gut, reovirus and rotavirus infection in the gut, and mouse models of inflammatory bowel disease. They explore the basic properties of neutrophils, macrophages, naïve and memory T cells, and dendritic cells, as well as genetic risk factors for complex immune-mediated diseases.

In LMI, studies on the molecular pathogenesis of infectious and immunologic/inflammatory diseases, including HIV/AIDS, West Nile virus infection, listeria infection, Trypanosoma cruzi, Toxoplasma gondii, fungal infection, sepsis, atherosclerosis, psoriasis, and primary immunodeficiency work toward a goal of identifying novel therapeutic targets and vaccine strategies.

Sections and Units

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Major Areas of Research

  • Structure and function of the mucosal immune system in the gastrointestinal system
  • Basic properties of neutrophils, naïve and memory T cells, macrophages, and dendritic cells
  • Genetic and epigenetic regulation of chemokine receptor expression
  • Chemokines as mediators in antimicrobial host defense, inflammation, and cancer

Last Updated May 09, 2013

Last Reviewed May 09, 2013